dbPTM

PIC2_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PIC2_YEAST
UniProt AC	P40035
Protein Name	Mitochondrial phosphate carrier protein 2
Gene Name	PIC2
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	300
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein .
Protein Description	Transport of phosphate groups from the cytosol to the mitochondrial matrix..
Protein Sequence	MESNKQPRKIQLYTKEFYATCTLGGIIACGPTHSSITPLDLVKCRLQVNPKLYTSNLQGFRKIIANEGWKKVYTGFGATFVGYSLQGAGKYGGYEYFKHLYSSWLSPGVTVYLMASATAEFLADIMLCPFEAIKVKQQTTMPPFCNNVVDGWKKMYAESGGMKAFYKGIVPLWCRQIPYTMCKFTSFEKIVQKIYSVLPKKKEEMNALQQISVSFVGGYLAGILCAAVSHPADVMVSKINSERKANESMSVASKRIYQKIGFTGLWNGLMVRIVMIGTLTSFQWLIYDSFKAYVGLPTTG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MESNKQPR -------CCCCCCCC	13.22	22814378
15	Ubiquitination	RKIQLYTKEFYATCT CEEEEECHHHEEEEE	32.06	17644757
43	Ubiquitination	ITPLDLVKCRLQVNP CCHHHHHCCEEEECC	22.42	17644757
189	Acetylation	CKFTSFEKIVQKIYS CCCCCHHHHHHHHHH	46.28	24489116
263	Phosphorylation	IYQKIGFTGLWNGLM HHHHHCCCHHHCCHH	26.59	24961812
278	Phosphorylation	VRIVMIGTLTSFQWL EEHHHCCCCHHHHHH	18.88	24961812
280	Phosphorylation	IVMIGTLTSFQWLIY HHHCCCCHHHHHHHH	27.60	24961812
281	Phosphorylation	VMIGTLTSFQWLIYD HHCCCCHHHHHHHHH	20.67	24961812
287	Phosphorylation	TSFQWLIYDSFKAYV HHHHHHHHHHHHHHC	11.90	24961812
289	Phosphorylation	FQWLIYDSFKAYVGL HHHHHHHHHHHHCCC	16.21	24961812

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PIC2_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PIC2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PIC2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SDT1_YEAST	SDT1	genetic	21623372
QCR2_YEAST	QCR2	genetic	21623372
ODPA_YEAST	PDA1	genetic	21623372
GSH1_YEAST	GSH1	genetic	21623372
ADH3_YEAST	ADH3	genetic	21623372
DCAM_YEAST	SPE2	genetic	21623372
PUR3_YEAST	ADE8	genetic	21623372
SUR2_YEAST	SUR2	genetic	21623372
G3P3_YEAST	TDH3	physical	22940862
SSB1_YEAST	SSB1	physical	22940862
HSP7F_YEAST	SSE1	physical	22940862
HSP71_YEAST	SSA1	physical	22940862
PABP_YEAST	PAB1	physical	22940862
HSP72_YEAST	SSA2	physical	22940862
CRS5_YEAST	CRS5	genetic	23846699
SEC6_YEAST	SEC6	genetic	27708008
CDC24_YEAST	CDC24	genetic	27708008
RFA1_YEAST	RFA1	genetic	27708008
KPC1_YEAST	PKC1	genetic	27708008
APC11_YEAST	APC11	genetic	27708008
CDC48_YEAST	CDC48	genetic	27708008
LCB2_YEAST	LCB2	genetic	27708008
TAF12_YEAST	TAF12	genetic	27708008
FCF1_YEAST	FCF1	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
RPN11_YEAST	RPN11	genetic	27708008
RPN12_YEAST	RPN12	genetic	27708008
SMD1_YEAST	SMD1	genetic	27708008
TAD3_YEAST	TAD3	genetic	27708008
ERB1_YEAST	ERB1	genetic	27708008
GPI15_YEAST	GPI15	genetic	27708008
NOP2_YEAST	NOP2	genetic	27708008
APC5_YEAST	APC5	genetic	27708008
SEC62_YEAST	SEC62	genetic	27708008
MRS3_YEAST	MRS3	genetic	26763345

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PIC2_YEAST

Related Literatures of Post-Translational Modification