CA120_YEAST - dbPTM
CA120_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CA120_YEAST
UniProt AC P53836
Protein Name CCR4-NOT transcriptional complex subunit CAF120
Gene Name CAF120
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1060
Subcellular Localization Cytoplasm . Nucleus . Bud neck .
Protein Description Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery..
Protein Sequence MRIFSGDNKVVDSLASNPGLMSPSNFGGDFGSRLKVNVTSKKKLNDSSPTSPMESSPVSPELVPILTLLNAHTHRRYHEGVFLILQDLNNNGTHAARKWKDVYGVLLGTQLALWDAKELAEFTDPSCPVSEKKLKEVASKPTYINLTDATLRTLDNSDNIVMECGKNLTNALVVSTTLKNRYFLQFGNKESFNAWNSAIRLCLYECSSLQEAYTGAFISSRGAKLGDIRILLTNRKYDYKDWVSVRFGAGMPWKRCYAVISQSSSKKKGHFGEINLYENDKKVKKNHAMATIVEAKALYAVYPSSPKLIDSSTIIKVVGSVKFEKKESAQEKDVFIMPEKHQAVPSYDTIIRFLIPAMDTFKLYGRPEKLLSSKNDPHSLLFGLPVLPHIYYLEVEDLLPLTNSVSSLHWSNNEWKEHISDILQRKIAQGYCGCNSTSNITSPLPSPFLGSADLFERADGVLSPKLSYGSKSSSNNSSKNSLPKRERVKLSSSSEQDLNNSDSPSIKRKSPPLVISESPHKVHTPTDASFRTRVTEGSPYAKQRHPKPFASSVNDSPSDRAKSRTVPYNNNDRKATTPEKFERGETSCGKNVDESLEKVRNMKLEIPESNFDKFMTDKNLLSVDSKCSNEKKLSVESDLSAIYEKYSNGPFGHTEGLNGSSDETYLRFQRASVHSESNYNSRKSFTPSDFSNGNEEEHAVLQELNSLTQRINELGMESINSNSDSDRINGSYSQVDFGNNNDEDDMNLFDPDFMAQDQLRAEERDYNKDDRTPLAKVPAAFQSTGLGITPDDDIERQYITEHRSRHEVPKRSPEKPSNPLEIGNPYAKPGTRLNTTHTHSKTDRSITPQRGQPVPSGQQISSYVQPANINSPNKMYGANNSAMGSPRNPKTRAPPGPYNQGWNNRPSPSNIYQRPHPSDTQPQAYHLPGNPYSTGNRPNMQAQYHPQQVPMPILQQPNRPYQPYAMNTHMGSPGGYAGAAPPFQPANVNYNTRPQQPWPTPNSPSAHYRPPPNLNQPQNGSAGYYRPPAPQLQNSQARPQKKDGFSQFMPSATTKNPYAQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MRIFSGDNKVVD
---CCCCCCCCCHHH		42.7521440633
22PhosphorylationASNPGLMSPSNFGGD
HCCCCCCCCCCCCCC		30.1628889911
24PhosphorylationNPGLMSPSNFGGDFG
CCCCCCCCCCCCCCC		37.1721440633
32PhosphorylationNFGGDFGSRLKVNVT
CCCCCCCCCEEEEEC		34.1421440633
47PhosphorylationSKKKLNDSSPTSPME
CCCCCCCCCCCCCCC		36.8230377154
50PhosphorylationKLNDSSPTSPMESSP
CCCCCCCCCCCCCCC		47.6230377154
51PhosphorylationLNDSSPTSPMESSPV
CCCCCCCCCCCCCCC		26.1530377154
130PhosphorylationTDPSCPVSEKKLKEV
CCCCCCCCHHHHHHH		28.9230377154
304PhosphorylationALYAVYPSSPKLIDS
HHHHHCCCCCCCCCC		41.4029734811
305PhosphorylationLYAVYPSSPKLIDSS
HHHHCCCCCCCCCCC		22.8821440633
441PhosphorylationCNSTSNITSPLPSPF
CCCCCCCCCCCCCCC		28.6621440633
442PhosphorylationNSTSNITSPLPSPFL
CCCCCCCCCCCCCCC		22.2021440633
446PhosphorylationNITSPLPSPFLGSAD
CCCCCCCCCCCCCHH		35.6521440633
451PhosphorylationLPSPFLGSADLFERA
CCCCCCCCHHHHHHC		22.2821551504
463PhosphorylationERADGVLSPKLSYGS
HHCCCCCCCCCCCCC		19.9924909858
472PhosphorylationKLSYGSKSSSNNSSK
CCCCCCCCCCCCCCC		40.4730377154
478PhosphorylationKSSSNNSSKNSLPKR
CCCCCCCCCCCCCHH		37.6723749301
491PhosphorylationKRERVKLSSSSEQDL
HHHHCCCCCCCHHHH		23.5822369663
492PhosphorylationRERVKLSSSSEQDLN
HHHCCCCCCCHHHHC		48.6024909858
493PhosphorylationERVKLSSSSEQDLNN
HHCCCCCCCHHHHCC		34.2222369663
494PhosphorylationRVKLSSSSEQDLNNS
HCCCCCCCHHHHCCC		41.0222369663
501PhosphorylationSEQDLNNSDSPSIKR
CHHHHCCCCCCCHHC		38.0920377248
503PhosphorylationQDLNNSDSPSIKRKS
HHHCCCCCCCHHCCC		21.9922369663
505PhosphorylationLNNSDSPSIKRKSPP
HCCCCCCCHHCCCCC		44.7022369663
510PhosphorylationSPSIKRKSPPLVISE
CCCHHCCCCCEEEEC		35.4622369663
516PhosphorylationKSPPLVISESPHKVH
CCCCEEEECCCCCCC		25.2522369663
518PhosphorylationPPLVISESPHKVHTP
CCEEEECCCCCCCCC		26.0522369663
524PhosphorylationESPHKVHTPTDASFR
CCCCCCCCCCCCHHH		30.7622369663
526PhosphorylationPHKVHTPTDASFRTR
CCCCCCCCCCHHHCC		45.4020377248
529PhosphorylationVHTPTDASFRTRVTE
CCCCCCCHHHCCCCC		20.3322369663
532PhosphorylationPTDASFRTRVTEGSP
CCCCHHHCCCCCCCC		27.7221440633
535PhosphorylationASFRTRVTEGSPYAK
CHHHCCCCCCCCCCC		31.1921440633
538PhosphorylationRTRVTEGSPYAKQRH
HCCCCCCCCCCCCCC		14.4321082442
540PhosphorylationRVTEGSPYAKQRHPK
CCCCCCCCCCCCCCC		28.2924961812
551PhosphorylationRHPKPFASSVNDSPS
CCCCCCCCCCCCCHH		34.8919823750
552PhosphorylationHPKPFASSVNDSPSD
CCCCCCCCCCCCHHH		22.8520377248
556PhosphorylationFASSVNDSPSDRAKS
CCCCCCCCHHHHHHH		22.5422369663
558PhosphorylationSSVNDSPSDRAKSRT
CCCCCCHHHHHHHCC		43.6220377248
563PhosphorylationSPSDRAKSRTVPYNN
CHHHHHHHCCCCCCC		32.0028889911
565PhosphorylationSDRAKSRTVPYNNND
HHHHHHCCCCCCCCC		32.6828889911
568PhosphorylationAKSRTVPYNNNDRKA
HHHCCCCCCCCCCCC		26.6228889911
576PhosphorylationNNNDRKATTPEKFER
CCCCCCCCCHHHHHC		46.0128889911
577PhosphorylationNNDRKATTPEKFERG
CCCCCCCCHHHHHCC		34.0220377248
586PhosphorylationEKFERGETSCGKNVD
HHHHCCCCCCCCCHH		31.9428889911
587PhosphorylationKFERGETSCGKNVDE
HHHCCCCCCCCCHHH		19.3028889911
622PhosphorylationMTDKNLLSVDSKCSN
CCCCCCCCCCCCCCC		27.3530377154
628PhosphorylationLSVDSKCSNEKKLSV
CCCCCCCCCCCCCCH		52.3321440633
634PhosphorylationCSNEKKLSVESDLSA
CCCCCCCCHHHHHHH		32.4922369663
637PhosphorylationEKKLSVESDLSAIYE
CCCCCHHHHHHHHHH		41.5219684113
640PhosphorylationLSVESDLSAIYEKYS
CCHHHHHHHHHHHHC		20.0119684113
643PhosphorylationESDLSAIYEKYSNGP
HHHHHHHHHHHCCCC		13.1919823750
646PhosphorylationLSAIYEKYSNGPFGH
HHHHHHHHCCCCCCC		8.7427017623
647PhosphorylationSAIYEKYSNGPFGHT
HHHHHHHCCCCCCCC		46.5127017623
660PhosphorylationHTEGLNGSSDETYLR
CCCCCCCCCCHHHHH		33.2823749301
661PhosphorylationTEGLNGSSDETYLRF
CCCCCCCCCHHHHHE		40.6422369663
664PhosphorylationLNGSSDETYLRFQRA
CCCCCCHHHHHEEEH		32.6122369663
665PhosphorylationNGSSDETYLRFQRAS
CCCCCHHHHHEEEHH		8.2022369663
672PhosphorylationYLRFQRASVHSESNY
HHHEEEHHCCCCCCC		23.6621440633
675PhosphorylationFQRASVHSESNYNSR
EEEHHCCCCCCCCCC		40.3321440633
686PhosphorylationYNSRKSFTPSDFSNG
CCCCCCCCHHHCCCC		29.0419779198
688PhosphorylationSRKSFTPSDFSNGNE
CCCCCCHHHCCCCCH		48.5119779198
721PhosphorylationLGMESINSNSDSDRI
HCHHHHHCCCCCCCC		35.7228889911
723PhosphorylationMESINSNSDSDRING
HHHHHCCCCCCCCCC		38.0128889911
725PhosphorylationSINSNSDSDRINGSY
HHHCCCCCCCCCCCC		28.7128889911
772PhosphorylationDYNKDDRTPLAKVPA
CCCCCCCCCHHHCCH		29.6428889911
812PhosphorylationRHEVPKRSPEKPSNP
CCCCCCCCCCCCCCC		43.4620377248
817PhosphorylationKRSPEKPSNPLEIGN
CCCCCCCCCCCCCCC		63.2530377154
842PhosphorylationTTHTHSKTDRSITPQ
CCCCCCCCCCCCCCC		39.3921551504
847PhosphorylationSKTDRSITPQRGQPV
CCCCCCCCCCCCCCC		18.0221440633
856PhosphorylationQRGQPVPSGQQISSY
CCCCCCCCCCCCCCC		49.8529688323
861PhosphorylationVPSGQQISSYVQPAN
CCCCCCCCCCCCCCC		15.9829688323
862PhosphorylationPSGQQISSYVQPANI
CCCCCCCCCCCCCCC		30.8429688323
863PhosphorylationSGQQISSYVQPANIN
CCCCCCCCCCCCCCC		9.0529688323
871PhosphorylationVQPANINSPNKMYGA
CCCCCCCCCCCCCCC		26.5021551504
876PhosphorylationINSPNKMYGANNSAM
CCCCCCCCCCCCCCC		18.0719779198
881PhosphorylationKMYGANNSAMGSPRN
CCCCCCCCCCCCCCC		21.3122369663
885PhosphorylationANNSAMGSPRNPKTR
CCCCCCCCCCCCCCC		13.9622369663
891PhosphorylationGSPRNPKTRAPPGPY
CCCCCCCCCCCCCCC		33.0628889911
907PhosphorylationQGWNNRPSPSNIYQR
CCCCCCCCCCCCCCC		37.4128889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CA120_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CA120_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CA120_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EIF3J_YEASTHCR1genetic
19061648
RS6A_YEASTRPS6Bgenetic
19061648
RS6B_YEASTRPS6Bgenetic
19061648
ARC1_YEASTARC1genetic
19061648
SYMM_YEASTMSM1genetic
19061648
EFTU_YEASTTUF1genetic
19061648
SAP30_YEASTSAP30genetic
19061648
DSS1_YEASTDSS1genetic
19061648
SYKM_YEASTMSK1genetic
19061648
SUV3_YEASTSUV3genetic
19061648
PAT1_YEASTPAT1genetic
19061648
TRM9_YEASTTRM9genetic
19061648
SYDM_YEASTMSD1genetic
19061648
SN309_YEASTSNT309genetic
19061648
MAK5_YEASTMAK5genetic
27708008
MPS1_YEASTMPS1genetic
27708008
UAP1_YEASTQRI1genetic
27708008
DBF4_YEASTDBF4genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
NCS1_YEASTFRQ1genetic
27708008
RSP5_YEASTRSP5genetic
27708008
GDI1_YEASTGDI1genetic
27708008
SWC4_YEASTSWC4genetic
27708008
DAM1_YEASTDAM1genetic
27708008
NUP57_YEASTNUP57genetic
27708008
MED6_YEASTMED6genetic
27708008
NDC80_YEASTNDC80genetic
27708008
CWC16_YEASTYJU2genetic
27708008
PWP1_YEASTPWP1genetic
27708008
POB3_YEASTPOB3genetic
27708008
TAF13_YEASTTAF13genetic
27708008
MYO2_YEASTMYO2genetic
27708008
MOT1_YEASTMOT1genetic
27708008
CDC27_YEASTCDC27genetic
27708008
IPYR_YEASTIPP1genetic
27708008
SEC18_YEASTSEC18genetic
27708008
MED8_YEASTMED8genetic
27708008
TAF5_YEASTTAF5genetic
27708008
NOP14_YEASTNOP14genetic
27708008
RLI1_YEASTRLI1genetic
27708008
SEC1_YEASTSEC1genetic
27708008
SEC7_YEASTSEC7genetic
27708008
COPB_YEASTSEC26genetic
27708008
TRS23_YEASTTRS23genetic
27708008
PSB3_YEASTPUP3genetic
27708008
CCA1_YEASTCCA1genetic
27708008
CDC4_YEASTCDC4genetic
27708008
GNA1_YEASTGNA1genetic
27708008
ACT_YEASTACT1genetic
27708008
CDC26_YEASTCDC26genetic
27708008
PSA1_YEASTSCL1genetic
27708008
PRS8_YEASTRPT6genetic
27708008
DUO1_YEASTDUO1genetic
27708008
RCC1_YEASTSRM1genetic
27708008
SMD1_YEASTSMD1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
HACD_YEASTPHS1genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
KTHY_YEASTCDC8genetic
27708008
RRN3_YEASTRRN3genetic
27708008
SN114_YEASTSNU114genetic
27708008
BOS1_YEASTBOS1genetic
27708008
NMT_YEASTNMT1genetic
27708008
MED11_YEASTMED11genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
PRP24_YEASTPRP24genetic
27708008
LCB1_YEASTLCB1genetic
27708008
NOP2_YEASTNOP2genetic
27708008
RPC6_YEASTRPC34genetic
27708008
MVD1_YEASTMVD1genetic
27708008
MED7_YEASTMED7genetic
27708008
SMP3_YEASTSMP3genetic
27708008
MED4_YEASTMED4genetic
27708008
DYR_YEASTDFR1genetic
27708008
RPA1_YEASTRPA190genetic
27708008
SEC16_YEASTSEC16genetic
27708008
CET1_YEASTCET1genetic
27708008
ARP7_YEASTARP7genetic
27708008
PSB5_YEASTPRE2genetic
27708008
THRC_YEASTTHR4genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
ATG1_YEASTATG1genetic
27708008
EMC5_YEASTEMC5genetic
27708008
YJ49_YEASTYJR079Wgenetic
27708008
VPS24_YEASTVPS24genetic
27708008
CCW12_YEASTCCW12genetic
27708008
YME1_YEASTYME1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CA120_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-491; SER-493; SER-494;SER-505 AND THR-524, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-510; SER-518; SER-538AND SER-556, AND MASS SPECTROMETRY.

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