YD23A_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YD23A_YEAST
• UniProt AC: Q99303
• Protein Name: Transposon Ty2-DR3 Gag polyprotein
• Gene Name: TY2A-DR3
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 438
• Subcellular Localization: Cytoplasm.
• Protein Description: Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty2 RNA and initiation of reverse transcription (By similarity)..
• Protein Sequence: MESQQLHQNPHSLHGSAAASVTSKEVPSNQDPLAVSASNLPEFDRDSTKVNSQQETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWAHYQQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIDSQNQHSEVPQAKTKVRNNVLPPHTLTSEENFSTWVKFYIRFLKNSNLGDIIPNDQGEIKRQMTYEEHAYIYNTFQAFAPFHLLPTWVKQILEINYADILTVLCKSVSKMQTNNQELKDWIALANLEYDGSTSADTFEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYLRNQYRTKTNMKLSQLFAEIQLIYDENKIMNLNKPSQYKQHSEYKNVSRTSPNTTNTKVTSRNYHRTNSSKPRAAKAHNIATSSKFSRVNNDHINESTVSSQYLSDDNELSLRPATERI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESQQLHQNP -----CCCCCHHCCC	23.17	28889911
28	Phosphorylation	VTSKEVPSNQDPLAV CCCCCCCCCCCCCEE	52.91	22369663
36	Phosphorylation	NQDPLAVSASNLPEF CCCCCEEECCCCCCC	22.00	22369663
38	Phosphorylation	DPLAVSASNLPEFDR CCCEEECCCCCCCCC	31.24	22369663
47	Phosphorylation	LPEFDRDSTKVNSQQ CCCCCCCCCCCCCCC	30.90	22369663
48	Phosphorylation	PEFDRDSTKVNSQQE CCCCCCCCCCCCCCC	43.21	22369663
52	Phosphorylation	RDSTKVNSQQETTPG CCCCCCCCCCCCCCC	35.91	28889911
57	Phosphorylation	VNSQQETTPGTSAVP CCCCCCCCCCCCCCC	20.97	18407956
71	Phosphorylation	PENHHHVSPQPASVP CCCCCCCCCCCCCCC	17.29	18407956
85	Phosphorylation	PPPQNGQYQQHGMMT CCCCCCCCCCCCCCC	16.13	27738172
92	Phosphorylation	YQQHGMMTPNKAMAS CCCCCCCCCCHHHHC	18.15	18407956
115	Phosphorylation	SMMTCSHYQTSPAYY CCCCCCCCCCCCCCC	9.37	18407956
117	Phosphorylation	MTCSHYQTSPAYYQP CCCCCCCCCCCCCCC	29.52	18407956
118	Phosphorylation	TCSHYQTSPAYYQPD CCCCCCCCCCCCCCC	7.63	18407956
140	Phosphorylation	YIPPLSTSSPDPIDS CCCCCCCCCCCCCCC	36.18	28889911
141	Phosphorylation	IPPLSTSSPDPIDSQ CCCCCCCCCCCCCCC	33.15	28889911
182	Ubiquitination	ENFSTWVKFYIRFLK CCHHHHHHHHHHHHH	24.82	17644757
189	Ubiquitination	KFYIRFLKNSNLGDI HHHHHHHHCCCCCCC	56.47	17644757
205	Ubiquitination	PNDQGEIKRQMTYEE CCCCCHHHCCCCHHH	32.07	17644757
209	Phosphorylation	GEIKRQMTYEEHAYI CHHHCCCCHHHHHHH	21.31	30377154
210	Phosphorylation	EIKRQMTYEEHAYIY HHHCCCCHHHHHHHH	17.61	30377154
215	Phosphorylation	MTYEEHAYIYNTFQA CCHHHHHHHHHHHHH	13.07	30377154
217	Phosphorylation	YEEHAYIYNTFQAFA HHHHHHHHHHHHHHC	8.75	30377154
219	Phosphorylation	EHAYIYNTFQAFAPF HHHHHHHHHHHHCCH	10.51	30377154
234	Ubiquitination	HLLPTWVKQILEINY HHHHHHHHHHHHCCH	24.15	17644757
250	Ubiquitination	DILTVLCKSVSKMQT HHHHHHHHHHHHCCC	50.13	17644757
294	Ubiquitination	STIIQRLKENNINVS HHHHHHHHHCCCCHH	61.66	17644757
311	Ubiquitination	LACQLILKGLSGDFK HHHHHHHHHHHCCHH	51.30	17644757
331	Ubiquitination	YRTKTNMKLSQLFAE HHHHHHHCHHHHHHH	47.24	17644757
347	Ubiquitination	QLIYDENKIMNLNKP HHHHCCCCCCCCCCH	41.08	17644757
353	Ubiquitination	NKIMNLNKPSQYKQH CCCCCCCCHHHHCCC	49.57	17644757
355	Phosphorylation	IMNLNKPSQYKQHSE CCCCCCHHHHCCCCC	47.99	21551504
358	Ubiquitination	LNKPSQYKQHSEYKN CCCHHHHCCCCCCCC	33.62	17644757
367	Phosphorylation	HSEYKNVSRTSPNTT CCCCCCCCCCCCCCC	38.95	22369663
369	Phosphorylation	EYKNVSRTSPNTTNT CCCCCCCCCCCCCCC	40.82	22369663
370	Phosphorylation	YKNVSRTSPNTTNTK CCCCCCCCCCCCCCC	18.29	22369663
373	Phosphorylation	VSRTSPNTTNTKVTS CCCCCCCCCCCCEEE	25.47	22369663
374	Phosphorylation	SRTSPNTTNTKVTSR CCCCCCCCCCCEEEC	47.75	22369663
376	Phosphorylation	TSPNTTNTKVTSRNY CCCCCCCCCEEECCC	25.46	22369663
383	Phosphorylation	TKVTSRNYHRTNSSK CCEEECCCCCCCCCC	7.49	27017623
386	Phosphorylation	TSRNYHRTNSSKPRA EECCCCCCCCCCCCH	26.58	27017623
388	Phosphorylation	RNYHRTNSSKPRAAK CCCCCCCCCCCCHHH	38.84	28889911
404	Ubiquitination	HNIATSSKFSRVNND HCHHCCCCCCCCCCC	47.31	23749301
406	Phosphorylation	IATSSKFSRVNNDHI HHCCCCCCCCCCCCC	38.77	19823750
416	Phosphorylation	NNDHINESTVSSQYL CCCCCCCCCCCCCCC	29.62	22369663
417	Phosphorylation	NDHINESTVSSQYLS CCCCCCCCCCCCCCC	20.44	22369663
419	Phosphorylation	HINESTVSSQYLSDD CCCCCCCCCCCCCCC	16.29	22369663
420	Phosphorylation	INESTVSSQYLSDDN CCCCCCCCCCCCCCC	20.64	22369663
422	Phosphorylation	ESTVSSQYLSDDNEL CCCCCCCCCCCCCCC	15.32	22369663
424	Phosphorylation	TVSSQYLSDDNELSL CCCCCCCCCCCCCCC	37.67	22369663
430	Phosphorylation	LSDDNELSLRPATER CCCCCCCCCCCCCCC	19.02	22369663
435	Phosphorylation	ELSLRPATERI---- CCCCCCCCCCC----	28.60	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YD23A_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YD23A_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YD23A_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YD23A_YEAST	YDR261W-A	physical	11283351
YD23B_YEAST	YDR261W-B	physical	11283351

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.