| UniProt ID | KEI1_YEAST | |
|---|---|---|
| UniProt AC | Q06346 | |
| Protein Name | Inositol phosphorylceramide synthase regulatory subunit KEI1 | |
| Gene Name | KEI1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 221 | |
| Subcellular Localization |
Golgi apparatus membrane Multi-pass membrane protein . |
|
| Protein Description | Regulatory component of the inositol phosphorylceramide (ICP) synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis. Helps the medial Golgi localization of IPC synthase in a COPI vesicle-dependent manner.. | |
| Protein Sequence | MRSSLLTLPKSFLGFMPLYLAVEIVLGISILNKCSGAYGILALFTGHPLDFMQWIAYLWSVFTLIVFSQGLYLIHKPNLLVFSQICVLYTIDTISTCFFTLWFTTQWFTLEDTANIDGNNALQSNPISTGKLTERGIDISKQSATESYEYTMTILITLVSLIFRFYFNFILASFVQELLHHPKYLVDRDDVEQNLKNKPIWKRLWAKSQKGCYKLCKNLLE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 128 | Phosphorylation | ALQSNPISTGKLTER CHHCCCCCCCCCCCC | 32.15 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KEI1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KEI1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KEI1_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ALG10_YEAST | DIE2 | genetic | 16269340 | |
| SEY1_YEAST | SEY1 | genetic | 16269340 | |
| NTE1_YEAST | NTE1 | genetic | 16269340 | |
| AUR1_YEAST | AUR1 | genetic | 19726565 | |
| AUR1_YEAST | AUR1 | physical | 19726565 | |
| KRE2_YEAST | KRE2 | physical | 19726565 | |
| HSP72_YEAST | SSA2 | physical | 22940862 | |
| DED1_YEAST | DED1 | physical | 22940862 | |
| SSB1_YEAST | SSB1 | physical | 22940862 | |
| HSP71_YEAST | SSA1 | physical | 22940862 | |
| G3P3_YEAST | TDH3 | physical | 22940862 | |
| UME6_YEAST | UME6 | genetic | 23891562 | |
| ERG7_YEAST | ERG7 | genetic | 23891562 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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