NTE1_YEAST - dbPTM
NTE1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NTE1_YEAST
UniProt AC Q04958
Protein Name Lysophospholipase NTE1
Gene Name NTE1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1679
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium..
Protein Sequence MRSMNCTTNNTNNTGQNTKNSLGSSFNSSNYTSYRFQTCLTDQIISEAQTWSLSSLFNFSWVVSYFVMGASRMIFRYGWYLATLSLLRIPKWIFFKLHHVQFTLSFWLILFALAVIVFVTYTIMKERILSQYKRLTPEFLPLENTGKSGSSANINAASTQSANAPPAIGSSTTGASSIIDSKKHSLKDGNENETFLSSYLDQFLSAIKIFGYLEKPVFHDLTKNMKTQKMDEGEILLLDSTIGFAIVVEGTLQLYHEVDHSDKDHGDETDHSDTDGLDDQDRDEEDEEEDDDIDNYDTKSCSSNLIDEEDESVGYIHLKNGLGNFQLLNTVKPGNPLTSLVSILNLFTHSMSSYGNSNFPSELSSPIDTTVSVNNMFCSSEQNFSNTDSMTNSTNSFPTFPSSMPKLVARAATDCTIGIIPPQSFAKLTAKYPRSASHIIQMVLTKLYHVTFQTAHDYLGLTKEIMDIEVLLNKSIVYELPYYLKEAVIRKFKTVDKSSGSADLEPKPKNSNASSKLKKPPKAKPSDGIIQSLKIANANANTSSNSLSLKPEFTHHPSSRHVVLGSRDQFNPGDLLSNVPLSRTMDILSPNPIHNNNRNKSNGINTSTSNQHKRSSRSSSNNASVHSKKFSSLSPELRNAQLSTSPLSLDNTSVHDHIHPSPVHLKGRVSPRPNLLPTTSFSAAQEETEDSALRMALVEAMLTYLGVNKSNMSVSSSSIANMSSLNSPQLNEMYSRRPSNASFLMSPHCTPSDISVASSFASPQTQPTMLRILPKEYTISNKRHNKSKSQDKKKPRAYKEELTPNLDFEDVKKDFAQGIQLKFFKKGTTIVEQNARGKGLFYIISGKVNVTTNSSSSVVSSMSKPEQVSAQSSHKGENPHHTQHLLYSVGSGGIVGYLSSLIGYKSFVNIVAKSDVYVGFLSSATLERLFDKYFLIYLRISDSLTKLLSSRLLKLDHALEWVHLRASETLFSQGDSANGIYVVLNGRLRQLQQQSLSNSNTSSEEVETQNIILGELAQGESFGEVEVLTAMNRYSTIVAVRDSELARIPRTLFELLALEHPSIMIRVSRLVAKKIVGDRTVPALTGDPLSIKENDFTSLIPPTKASYSSSLSHKPQNITSGTITFRTITILPITSGLPVEAFAMKLVQAFKQVGRTTIGLNQRTTLTHLGRHAFDRLSKLKQSGYFAELEEMYQTVVYISDTPVKSNWTRTCIAQGDCILLLADARSPSAEIGEYEKLLLNSKTTARTELILLHPERYVEPGLTHKWLRYRPWVHSHHHIQFSLTGTTLMNEGKMHVLNNGALALMDKLIQTEFSRKTQQNISKLLPDSIKNTVENFSSRFMKSKRQYYTPVHRHKNDFLRLARILSGQAIGLVLGGGGARGISHLGVIQAIEEQGIPVDVIGGTSIGSFVGGLYAKDYDLVPIYGRVKKFAGRISSIWRMLTDLTWPVTSYTTGHEFNRGIWKTFGDTRIEDFWIQYYCNSTNITDSVQEIHSFGYAWRYIRASMSLAGLLPPLEENGSMLLDGGYVDNLPVTEMRARGCQTIFAVDVGSADDRTPMEYGDSLNGFWIIFNRWNPFSSHPNIPNMAEIQVRLGYVASVNALEKAKNTPGVVYVRPPIEEYATLDFSKFEEIYHVGVDYGRIFLQGLIDDDKMPYIPGSQETTLNSQVPEFLLHRRNSI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
136PhosphorylationLSQYKRLTPEFLPLE
HHHHHHHCCCCCCCC		25.4627214570
148PhosphorylationPLENTGKSGSSANIN
CCCCCCCCCCCCCCC		45.3027017623
150PhosphorylationENTGKSGSSANINAA
CCCCCCCCCCCCCCC		33.1127017623
151PhosphorylationNTGKSGSSANINAAS
CCCCCCCCCCCCCCC		28.9427017623
158PhosphorylationSANINAASTQSANAP
CCCCCCCCCCCCCCC		25.2727017623
181PhosphorylationGASSIIDSKKHSLKD
CCHHHHHCCCCCCCC		32.9427017623
215AcetylationKIFGYLEKPVFHDLT
HHHHHCCCHHHHHHH		43.8424489116
223AcetylationPVFHDLTKNMKTQKM
HHHHHHHHCCCCCCC		63.4424489116
269PhosphorylationDKDHGDETDHSDTDG
CCCCCCCCCCCCCCC		43.6921551504
272PhosphorylationHGDETDHSDTDGLDD
CCCCCCCCCCCCCCC		45.0421551504
274PhosphorylationDETDHSDTDGLDDQD
CCCCCCCCCCCCCCC		34.6721551504
300PhosphorylationIDNYDTKSCSSNLID
CCCCCCCCHHHCCCC		22.7120377248
302PhosphorylationNYDTKSCSSNLIDEE
CCCCCCHHHCCCCCC		29.3820377248
303PhosphorylationYDTKSCSSNLIDEED
CCCCCHHHCCCCCCC		39.7319823750
312PhosphorylationLIDEEDESVGYIHLK
CCCCCCCCCCEEEEE		32.9120377248
315PhosphorylationEEDESVGYIHLKNGL
CCCCCCCEEEEECCC		5.3019779198
445PhosphorylationHIIQMVLTKLYHVTF
HHHHHHHHHHHHCCH		13.9521551504
454PhosphorylationLYHVTFQTAHDYLGL
HHHCCHHHHHHHHCC		23.0521551504
458PhosphorylationTFQTAHDYLGLTKEI
CHHHHHHHHCCCHHH		7.8721551504
462PhosphorylationAHDYLGLTKEIMDIE
HHHHHCCCHHHHHHH		25.4921551504
494PhosphorylationAVIRKFKTVDKSSGS
HHHHHCCCCCCCCCC		36.7519823750
498PhosphorylationKFKTVDKSSGSADLE
HCCCCCCCCCCCCCC		35.1519823750
499PhosphorylationFKTVDKSSGSADLEP
CCCCCCCCCCCCCCC		42.3719823750
501PhosphorylationTVDKSSGSADLEPKP
CCCCCCCCCCCCCCC		22.1319823750
526PhosphorylationKPPKAKPSDGIIQSL
CCCCCCCCCCHHHHH		48.0030377154
532PhosphorylationPSDGIIQSLKIANAN
CCCCHHHHHEEECCC		22.6330377154
542PhosphorylationIANANANTSSNSLSL
EECCCCCCCCCCCCC		30.9930377154
543PhosphorylationANANANTSSNSLSLK
ECCCCCCCCCCCCCC		27.5919779198
544PhosphorylationNANANTSSNSLSLKP
CCCCCCCCCCCCCCC		28.5321440633
546PhosphorylationNANTSSNSLSLKPEF
CCCCCCCCCCCCCCC		22.6819779198
548PhosphorylationNTSSNSLSLKPEFTH
CCCCCCCCCCCCCCC		33.8819779198
601PhosphorylationHNNNRNKSNGINTST
CCCCCCCCCCCCCCC		43.7824909858
606PhosphorylationNKSNGINTSTSNQHK
CCCCCCCCCCCCHHH		31.3119823750
607PhosphorylationKSNGINTSTSNQHKR
CCCCCCCCCCCHHHC		25.9219823750
608PhosphorylationSNGINTSTSNQHKRS
CCCCCCCCCCHHHCC		29.6519823750
609PhosphorylationNGINTSTSNQHKRSS
CCCCCCCCCHHHCCC		33.9719823750
615PhosphorylationTSNQHKRSSRSSSNN
CCCHHHCCCCCCCCC		34.6027717283
616PhosphorylationSNQHKRSSRSSSNNA
CCHHHCCCCCCCCCC		39.9719823750
618PhosphorylationQHKRSSRSSSNNASV
HHHCCCCCCCCCCCH		39.8119823750
619PhosphorylationHKRSSRSSSNNASVH
HHCCCCCCCCCCCHH		35.6519823750
620PhosphorylationKRSSRSSSNNASVHS
HCCCCCCCCCCCHHH		35.0419823750
624PhosphorylationRSSSNNASVHSKKFS
CCCCCCCCHHHHHHH		23.6119823750
627PhosphorylationSNNASVHSKKFSSLS
CCCCCHHHHHHHHCC		35.0719823750
631PhosphorylationSVHSKKFSSLSPELR
CHHHHHHHHCCHHHH		38.9722369663
632PhosphorylationVHSKKFSSLSPELRN
HHHHHHHHCCHHHHH		35.6822369663
634PhosphorylationSKKFSSLSPELRNAQ
HHHHHHCCHHHHHCC		20.4822369663
643PhosphorylationELRNAQLSTSPLSLD
HHHHCCCCCCCCCCC		18.1119779198
644PhosphorylationLRNAQLSTSPLSLDN
HHHCCCCCCCCCCCC		42.8528889911
645PhosphorylationRNAQLSTSPLSLDNT
HHCCCCCCCCCCCCC		22.0728889911
648PhosphorylationQLSTSPLSLDNTSVH
CCCCCCCCCCCCCCC		36.7428889911
652PhosphorylationSPLSLDNTSVHDHIH
CCCCCCCCCCCCCCC		31.6228889911
653PhosphorylationPLSLDNTSVHDHIHP
CCCCCCCCCCCCCCC		24.5721440633
661PhosphorylationVHDHIHPSPVHLKGR
CCCCCCCCCCCCCCC		25.9528889911
670PhosphorylationVHLKGRVSPRPNLLP
CCCCCCCCCCCCCCC		17.5227738172
678PhosphorylationPRPNLLPTTSFSAAQ
CCCCCCCCCCCCCCC		34.7321440633
679PhosphorylationRPNLLPTTSFSAAQE
CCCCCCCCCCCCCCH		26.3228889911
680PhosphorylationPNLLPTTSFSAAQEE
CCCCCCCCCCCCCHH		21.4917563356
682PhosphorylationLLPTTSFSAAQEETE
CCCCCCCCCCCHHCH		23.5928889911
716PhosphorylationKSNMSVSSSSIANMS
CCCCCCCHHHHCCHH		26.4227017623
717PhosphorylationSNMSVSSSSIANMSS
CCCCCCHHHHCCHHH		20.4619779198
718PhosphorylationNMSVSSSSIANMSSL
CCCCCHHHHCCHHHC		27.8919779198
727PhosphorylationANMSSLNSPQLNEMY
CCHHHCCCHHHHHHH		21.2219779198
739PhosphorylationEMYSRRPSNASFLMS
HHHHCCCCCCCCCCC		43.1228889911
742PhosphorylationSRRPSNASFLMSPHC
HCCCCCCCCCCCCCC		24.1421440633
746PhosphorylationSNASFLMSPHCTPSD
CCCCCCCCCCCCHHH		17.4019779198
750PhosphorylationFLMSPHCTPSDISVA
CCCCCCCCHHHCCHH		23.8519779198
752PhosphorylationMSPHCTPSDISVASS
CCCCCCHHHCCHHHH		29.4419779198
755PhosphorylationHCTPSDISVASSFAS
CCCHHHCCHHHHCCC		19.3419779198
777PhosphorylationLRILPKEYTISNKRH
EHHCCCCCCCCCCCC		18.5928889911
778PhosphorylationRILPKEYTISNKRHN
HHCCCCCCCCCCCCC		21.0128889911
780PhosphorylationLPKEYTISNKRHNKS
CCCCCCCCCCCCCCC		28.6228889911
803PhosphorylationRAYKEELTPNLDFED
HHHHCCCCCCCCHHH		17.2617330950
828PhosphorylationLKFFKKGTTIVEQNA
EEEEECCCEEEEECC		23.4119823750
829PhosphorylationKFFKKGTTIVEQNAR
EEEECCCEEEEECCC		31.5219823750
842PhosphorylationARGKGLFYIISGKVN
CCCCCEEEEEECEEE		11.4619823750
845PhosphorylationKGLFYIISGKVNVTT
CCEEEEEECEEEEEC		24.0119823750
851PhosphorylationISGKVNVTTNSSSSV
EECEEEEECCCCCCC		18.3027017623
852PhosphorylationSGKVNVTTNSSSSVV
ECEEEEECCCCCCCC		28.9027017623
854PhosphorylationKVNVTTNSSSSVVSS
EEEEECCCCCCCCCC		29.5127017623
11792-HydroxyisobutyrylationHAFDRLSKLKQSGYF
HHHHHHHHHHHCCCC		65.38-
1183PhosphorylationRLSKLKQSGYFAELE
HHHHHHHCCCCHHHH		33.6028889911
1185PhosphorylationSKLKQSGYFAELEEM
HHHHHCCCCHHHHHH		12.5928889911
1193PhosphorylationFAELEEMYQTVVYIS
CHHHHHHHCEEEEEE		12.3328889911
1198PhosphorylationEMYQTVVYISDTPVK
HHHCEEEEEECCCCC		7.1428889911
1266AcetylationVEPGLTHKWLRYRPW
CCCCCCCCHHHCCCC		42.5624489116
1344PhosphorylationFSSRFMKSKRQYYTP
HHHHHHHHCHHCCCC		22.6827017623
1655PhosphorylationIDDDKMPYIPGSQET
CCCCCCCCCCCCCCC		19.0919823750
1659PhosphorylationKMPYIPGSQETTLNS
CCCCCCCCCCCCCCC		21.3519823750
1662PhosphorylationYIPGSQETTLNSQVP
CCCCCCCCCCCCCCC		29.0119823750
1663PhosphorylationIPGSQETTLNSQVPE
CCCCCCCCCCCCCCH		24.1621440633
1666PhosphorylationSQETTLNSQVPEFLL
CCCCCCCCCCCHHHH		35.3525521595
1678PhosphorylationFLLHRRNSI------
HHHHHHCCC------		28.0625521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NTE1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NTE1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NTE1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ODPB_YEASTPDB1physical
11805826
IMB3_YEASTPSE1physical
11805826
KEI1_YEASTKEI1genetic
16269340
MSMO_YEASTERG25genetic
16269340
BFR1_YEASTBFR1genetic
16269340
BAS1_YEASTBAS1genetic
19269370
GLRX2_YEASTGRX2genetic
21623372
CHMU_YEASTARO7genetic
21623372
METC_YEASTIRC7genetic
21623372
PDX3_YEASTPDX3genetic
21623372
ERG2_YEASTERG2genetic
21623372
DYR_YEASTDFR1genetic
27708008
PRP11_YEASTPRP11genetic
27708008
COPA_YEASTCOP1genetic
27708008
CDC37_YEASTCDC37genetic
27708008
RMRP_YEASTSNM1genetic
27708008
SMD1_YEASTSMD1genetic
27708008
TEL2_YEASTTEL2genetic
27708008
MED6_YEASTMED6genetic
27708008
SEC22_YEASTSEC22genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
DBP6_YEASTDBP6genetic
27708008
NUF2_YEASTNUF2genetic
27708008
CLP1_YEASTCLP1genetic
27708008
TBF1_YEASTTBF1genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
SWC5_YEASTSWC5genetic
27708008
STE50_YEASTSTE50genetic
27708008
RIM1_YEASTRIM1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
ARF2_YEASTARF2genetic
27708008
NOP6_YEASTNOP6genetic
27708008
DTD_YEASTDTD1genetic
27708008
RKM2_YEASTRKM2genetic
27708008
YD249_YEASTYDR249Cgenetic
27708008
ATC1_YEASTPMR1genetic
27708008
YG2W_YEASTYGR111Wgenetic
27708008
RL24B_YEASTRPL24Bgenetic
27708008
CHO2_YEASTCHO2genetic
27708008
CBP4_YEASTCBP4genetic
27708008
QCR9_YEASTQCR9genetic
27708008
TNA1_YEASTTNA1genetic
27708008
YHE4_YEASTYHL044Wgenetic
27708008
GIC1_YEASTGIC1genetic
27708008
IME1_YEASTIME1genetic
27708008
HAP4_YEASTHAP4genetic
27708008
SLX4_YEASTSLX4genetic
27708008
SKG3_YEASTSKG3genetic
27708008
ASI3_YEASTASI3genetic
27708008
YNB0_YEASTYNL010Wgenetic
27708008
HOL1_YEASTHOL1genetic
27708008
HMI1_YEASTHMI1genetic
27708008
6P22_YEASTPFK27genetic
27708008
RAS1_YEASTRAS1genetic
27708008
COQ7_YEASTCAT5genetic
27708008
FABD_YEASTMCT1genetic
27708008
RTC6_YEASTRTC6genetic
27708008
YP257_YEASTYPL257Wgenetic
27708008
MDL2_YEASTMDL2genetic
27708008
YME1_YEASTYME1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NTE1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303; SER-634; SER-670;THR-679; SER-680; SER-682 AND THR-803, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-634; SER-670 ANDSER-680, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-634, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-634, AND MASSSPECTROMETRY.

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