CDK1_SCHPO - dbPTM
CDK1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDK1_SCHPO
UniProt AC P04551
Protein Name Cyclin-dependent kinase 1
Gene Name cdc2
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 297
Subcellular Localization Cytoplasm .
Protein Description Plays a key role in the control of the eukaryotic cell cycle. It is required for entry into S-phase and mitosis. When complexed with cig2, plays a role in G1-S phase transition. When activated and complexed with the cyclin cdc13, it leads to the onset of mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. Involved in cell cycle arrest induced by defective RNA splicing. Required for phosphorylation of dis1 to ensure accurate chromosome segregation and for the DNA damage checkpoint..
Protein Sequence MENYQKVEKIGEGTYGVVYKARHKLSGRIVAMKKIRLEDESEGVPSTAIREISLLKEVNDENNRSNCVRLLDILHAESKLYLVFEFLDMDLKKYMDRISETGATSLDPRLVQKFTYQLVNGVNFCHSRRIIHRDLKPQNLLIDKEGNLKLADFGLARSFGVPLRNYTHEIVTLWYRAPEVLLGSRHYSTGVDIWSVGCIFAEMIRRSPLFPGDSEIDEIFKIFQVLGTPNEEVWPGVTLLQDYKSTFPRWKRMDLHKVVPNGEEDAIELLSAMLVYDPAHRISAKRALQQNYLRDFH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationVEKIGEGTYGVVYKA
EEECCCCCCEEEEEE		16.8924763107
15PhosphorylationEKIGEGTYGVVYKAR
EECCCCCCEEEEEEE		20.842682257
167PhosphorylationGVPLRNYTHEIVTLW
CCCCCCCCCEEEEEE		19.3128889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CDK1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CDK1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CDK1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPD1_SCHPOspd1genetic
8887552
CDC10_SCHPOcdc10genetic
11513869
HSP90_SCHPOhsp90genetic
10102358
MPIP_SCHPOcdc25genetic
9013342
DED1_SCHPOsum3genetic
11711540
CID13_SCHPOcid13genetic
12062100
CKS1_SCHPOsuc1genetic
9790601
CG23_SCHPOcdc13genetic
9790601
WEE1_SCHPOwee1genetic
9188094
CHK1_SCHPOchk1genetic
8497322
CKS1_SCHPOsuc1genetic
3322810
DIMI_SCHPOdim1genetic
9182666
CG23_SCHPOcdc13genetic
1533272
WEE1_SCHPOwee1genetic
2474475
CGM2_SCHPOmcs2genetic
2474475
RES2_SCHPOres2genetic
2474475
MCS4_SCHPOmcs4genetic
2474475
CRK1_SCHPOmcs6genetic
2474475
CKS1_SCHPOsuc1genetic
3010051
CRK1_SCHPOmcs6genetic
8557037
DED1_SCHPOsum3genetic
9832516
RUM1_SCHPOrum1genetic
7593289
WOS2_SCHPOwos2genetic
10581266
WEE1_SCHPOwee1genetic
11029045
RES2_SCHPOres2genetic
11029045
EIF3I_SCHPOsum1genetic
9560390
PYP1_SCHPOpyp1genetic
9560390
HOG1_SCHPOsty1genetic
9560390
FLP1_SCHPOclp1genetic
16950131
PP11_SCHPOdis2physical
7957097
SDS23_SCHPOsds23physical
9242669
SPD1_SCHPOspd1physical
8887552
CG1C_SCHPOpch1physical
9115279
CG23_SCHPOcdc13physical
11683390
CG23_SCHPOcdc13physical
11329175
RUM1_SCHPOrum1physical
11329175
WOS2_SCHPOwos2physical
10581266
BUB1_SCHPObub1physical
12606573
SMC4_SCHPOcut3physical
10485849
CDC18_SCHPOcdc18physical
9177184
ORC2_SCHPOorc2physical
11486016
RUM1_SCHPOrum1physical
10679013
RHP9_SCHPOcrb2physical
10488332
CDC18_SCHPOcdc18physical
9436991
RUM1_SCHPOrum1physical
12167173
RUM1_SCHPOrum1physical
9303310
HCN1_SCHPOhcn1physical
16950791
FLP1_SCHPOclp1physical
16950131
PP11_SCHPOdis2physical
16920624
FKH2_SCHPOfkh2physical
18059475
MDE4_SCHPOmde4physical
19523829
ASE1_SCHPOase1physical
19686686
CKS1_SCHPOsuc1genetic
16453733
KCC2_SCHPOcmk2genetic
12135745
CG23_SCHPOcdc13genetic
11711540
CHK1_SCHPOchk1genetic
11711540
PYP3_SCHPOpyp3genetic
1464318
MPIP_SCHPOcdc25genetic
20444100
MBX1_SCHPOmbx1physical
21098641
NSK1_SCHPOnsk1physical
22065639
HSP9_SCHPOhsp9genetic
22182414
RUM1_SCHPOrum1physical
22144913
CDC18_SCHPOcdc18physical
22144913
H10_BOVINH1F0physical
22683458
MPIP_SCHPOcdc25physical
22665807
ELP3_SCHPOelp3genetic
22768388
CTU1_SCHPOctu1genetic
22768388
WEE1_SCHPOwee1genetic
9013342
SPM1_SCHPOpmk1genetic
22918952
FLP1_SCHPOclp1physical
22918952
CHK1_SCHPOchk1genetic
10637286
MIK1_SCHPOmik1genetic
10637286
SNF5_SCHPOsnf5genetic
22681890
RIA1_SCHPOria1genetic
22681890
H2A2_SCHPOhta2genetic
16314498
H2A1_SCHPOhta1genetic
16314498
CUT12_SCHPOcut12genetic
2245912
SWR1_SCHPOswr1genetic
9571240
CG23_SCHPOcdc13genetic
7909513
FLP1_SCHPOclp1genetic
23297348
CUT12_SCHPOcut12genetic
23333317
CUT12_SCHPOcut12physical
23333317
ORC2_SCHPOorc2physical
8552194
CKS1_SCHPOsuc1genetic
1896017
CG23_SCHPOcdc13genetic
1934126
CG23_SCHPOcdc13physical
2569363
H15_HUMANHIST1H1Bphysical
2569363
ORC2_SCHPOorc2genetic
8552194
RHP9_SCHPOcrb2physical
24074952
CG22_SCHPOcig2genetic
8455610
BYR4_SCHPObyr4physical
24920823
MPIP_SCHPOcdc25genetic
24861625
MIK1_SCHPOmik1genetic
24861625
CDS1_SCHPOcds1genetic
24861625
CHK1_SCHPOchk1genetic
24861625
RHP9_SCHPOcrb2genetic
24861625
SRS2_SCHPOsrs2physical
24861625
HUS2_SCHPOrqh1physical
24861625
KU70_SCHPOpku70physical
24861625
KU80_SCHPOpku80physical
24861625
MUS81_SCHPOmus81physical
24861625
RAD16_SCHPOrad16physical
24861625
CHK1_SCHPOchk1physical
24861625
HHP1_SCHPOhhp1physical
24861625
ALP7_SCHPOalp7physical
24790093
CKS1_SCHPOsuc1physical
26771498
CG23_SCHPOcdc13physical
26771498
PP11_SCHPOdis2physical
26771498
GAD8_SCHPOgad8physical
26912660
PP11_SCHPOdis2physical
25487150
FKH2_SCHPOfkh2physical
26804917
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDK1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-15 AND THR-167, AND MASSSPECTROMETRY.
"Shotgun identification of protein modifications from proteincomplexes and lens tissue.";
MacCoss M.J., McDonald W.H., Saraf A., Sadygov R., Clark J.M.,Tasto J.J., Gould K.L., Wolters D., Washburn M., Weiss A., Clark J.I.,Yates J.R. III;
Proc. Natl. Acad. Sci. U.S.A. 99:7900-7905(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-15 AND THR-167, AND MASSSPECTROMETRY.
"Tyrosine phosphorylation of the fission yeast cdc2+ protein kinaseregulates entry into mitosis.";
Gould K.L., Nurse P.;
Nature 342:39-45(1989).
Cited for: PHOSPHORYLATION AT TYR-15.

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