CDC10_SCHPO - dbPTM
CDC10_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDC10_SCHPO
UniProt AC P01129
Protein Name Start control protein cdc10
Gene Name cdc10
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 767
Subcellular Localization Nucleus .
Protein Description Major component of the cell cycle transcription factor complex MBF (MCB binding factor, also known as DSC1), that controls G1-S phase specific gene expression. Involved in the control of rRNA production, via interaction with pol5. May be involved in the transcriptional regulation of the cdc22 and cdt1 genes. In fission yeast, two genes, cdc10 and cdc2, are required for the cell cycle control called start, the point early in the G1 phase at which cells become committed to the mitotic cycle..
Protein Sequence MASANFIRQFELGNDSFSYQKRPEDEPSQPLSNRNINKLNDSSTLKDSSSRIFINSQVLRDGRPVELYAVECSGMKYMELSCGDNVALRRCPDSYFNISQILRLAGTSSSENAKELDDIIESGDYENVDSKHPQIDGVWVPYDRAISIAKRYGVYEILQPLISFNLDLFPKFSKQQQIESSSISKNLNTSSFNTRSPLRNHNFSNPSKSSKNGVHTINNMQSSPSPSSSFLLPLTQIDSQNVKRSNNYLSTSPPILEQRLKRHRIDVSDEDLHPSSQLNDNEASSLFPDTPRLNHSLSFVSLVSSLPPLDQNIMQDYHTSKDILTSIFLDVNFADSSALEAKLSDSLDLDVPIDELGHAALHWAAAVAKMPLLQALIHKGANPLRGNLTGETALMRSVLVTNHLNQNSFGDLLDLLYASLPCTDRAGRTVVHHICLTAGIKGRGSASRYYLETLLNWAKKHASGNNGYMLKDFINYLNHQDKNGDTALNIAARIGNKNIVEVLMQAGASAYIPNRAGLSVANFGIFVENALKQPEDSKQTKVSLMSENLSSKEKTAVPPRQKSRDIIASVTDVISSLDKDFQDEMAAKQSMIDSAYTQLRESTKKLSDLREQLHVSETQRTLFLELRQRCKNLMTSIEEQKSELSNLYESFDPNGIHDSLSLDADAPFTVNENNNKNLSIAELKFQVAAYERNEARLNELANKLWQRNSNIKSKCRRVVSLCTGVDESRVDSLLESLLQAVESDGQQGEVDMGRVAGFLRVVKEHQA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16PhosphorylationQFELGNDSFSYQKRP
EECCCCCCCCCCCCC		21.7921712547
189PhosphorylationSISKNLNTSSFNTRS
HHHCCCCCCCCCCCC		28.9921712547
190PhosphorylationISKNLNTSSFNTRSP
HHCCCCCCCCCCCCC		31.6829996109
191PhosphorylationSKNLNTSSFNTRSPL
HCCCCCCCCCCCCCC		22.0729996109
194PhosphorylationLNTSSFNTRSPLRNH
CCCCCCCCCCCCCCC		30.4329996109
196PhosphorylationTSSFNTRSPLRNHNF
CCCCCCCCCCCCCCC		26.6729996109
204PhosphorylationPLRNHNFSNPSKSSK
CCCCCCCCCCCCCCC		53.8221712547
216PhosphorylationSSKNGVHTINNMQSS
CCCCCCCCCCCCCCC		24.0021712547
222PhosphorylationHTINNMQSSPSPSSS
CCCCCCCCCCCCCCC		33.1921712547
223PhosphorylationTINNMQSSPSPSSSF
CCCCCCCCCCCCCCC		16.7121712547
225PhosphorylationNNMQSSPSPSSSFLL
CCCCCCCCCCCCCEE		39.0924763107
227PhosphorylationMQSSPSPSSSFLLPL
CCCCCCCCCCCEEEH		42.8424763107
228PhosphorylationQSSPSPSSSFLLPLT
CCCCCCCCCCEEEHH		28.6121712547
248PhosphorylationNVKRSNNYLSTSPPI
CCCCCCCCCCCCHHH		13.2829996109
250PhosphorylationKRSNNYLSTSPPILE
CCCCCCCCCCHHHHH		19.2421712547
252PhosphorylationSNNYLSTSPPILEQR
CCCCCCCCHHHHHHH		25.8828889911
268PhosphorylationKRHRIDVSDEDLHPS
HHCCCCCCCCCCCCH		31.3829996109
563PhosphorylationAVPPRQKSRDIIASV
CCCCCHHHHHHHHHH		27.1824763107
569PhosphorylationKSRDIIASVTDVISS
HHHHHHHHHHHHHHH		18.3621712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CDC10_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CDC10_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CDC10_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DPO5_SCHPOpol5physical
16816948
MIK1_SCHPOmik1genetic
11513869
TBB_SCHPOnda3genetic
9679144
CG23_SCHPOcdc13genetic
8895572
RES1_SCHPOres1genetic
9118941
RES2_SCHPOres2genetic
9118941
RES2_SCHPOres2genetic
7926774
RES1_SCHPOres1genetic
7739540
CDT1_SCHPOcdt1genetic
8313888
RAD4_SCHPOrad4genetic
8343962
RHO2_SCHPOrho2genetic
9405296
REP2_SCHPOrep2genetic
7588609
RES1_SCHPOres1genetic
1522142
RUM1_SCHPOrum1genetic
9472012
RES1_SCHPOres1physical
10564266
RES2_SCHPOres2physical
10564266
RES2_SCHPOres2physical
9118941
RES1_SCHPOres1physical
9118941
PMO25_SCHPOpmo25genetic
16096637
NAK1_SCHPOnak1genetic
16096637
MOR2_SCHPOmor2genetic
16096637
CKI3_SCHPOcki3genetic
20501954
GAD8_SCHPOgad8genetic
20501954
PEF1_SCHPOpef1genetic
20501954
PIT1_SCHPOpit1genetic
20501954
PPK19_SCHPOppk19genetic
20501954
YOX1_SCHPOyox1physical
21132016
RES2_SCHPOres2physical
21132016
RES1_SCHPOres1physical
21132016
TPP1_SCHPOtpp1genetic
22681890
HRP3_SCHPOhrp3genetic
22681890
FIN1_SCHPOfin1genetic
22681890
REB1_SCHPOreb1genetic
22681890
YAD4_SCHPOSPAC4G8.04genetic
22681890
YCGK_SCHPOSPCC16C4.20cgenetic
22681890
VIP1_SCHPOasp1genetic
22681890
SPP1_SCHPOspf1genetic
22681890
WIS4_SCHPOwis4genetic
22681890
GBB_SCHPOgit5genetic
22681890
PDS5_SCHPOpds5genetic
22681890
GLD1_SCHPOgld1genetic
22681890
SLD3_SCHPOsld3genetic
22681890
PRS10_SCHPOrpt4genetic
22681890
MUG87_SCHPOnup97genetic
22681890
APS1_SCHPOaps1genetic
22681890
RUM1_SCHPOrum1genetic
9571240
SWR1_SCHPOswr1genetic
9571240
RES2_SCHPOres2genetic
8168485
FLP1_SCHPOclp1physical
23297348
CDC18_SCHPOcdc18genetic
10490657
SPD1_SCHPOspd1genetic
8887552
RES2_SCHPOres2physical
24006488
CDC18_SCHPOcdc18physical
24006488
RIR1_SCHPOcdc22physical
24006488
CDC10_SCHPOcdc10physical
26771498
SEC6_SCHPOsec6physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDC10_SCHPO

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory