NAK1_SCHPO - dbPTM
NAK1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NAK1_SCHPO
UniProt AC O75011
Protein Name Serine/threonine-protein kinase nak1
Gene Name nak1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 652
Subcellular Localization Cytoplasm .
Protein Description Has a role in the regulation of cell polarity, growth and division..
Protein Sequence MENNTASSPYTKLELVGRGSYGAVYRGICNLTKETVAIKILNLDTDEDEVSDIQKEVAVLSELKQSDVENIIKYHGSYLVGTNLWIIMDYCHGGSVRTLMEAGPISEPCISLILRETLQALKFIHHAGIIHRDIKAANILVSMSGNVKLCDFGVAAELNINRRKRITFIGTPYWMAPEVIRDGQEYNVMADIWSLGITAYEIATGSPPHAKEDPFRAVYLIAHTAPPRLNGNFSALLKEFIASCLQDVPQRRLDSSELLKSKFIKQYSRMSISELTNVVKRYDTWQAAGGIPQTLLLGEEADDGSDPDQETSDTAASDDGWEFGTIKQGQSNVSSITGTSTSTTTAATSSTTVTGTVIPKSSTVHEPPSSNDSHPLLQLFKDSKISDDDSPSNAEGASTEDSKGEVSYSQIELPSLDSSNLSSKKSTIQSKHTKQAEDYDLFVGRTRSNSKTSSDQSIKRPLPRVVQRQKTSLGKRGISMSPMKPGLRMPSSFDLQSRSISMGAFEQLSTPLEAPAHKHSAVLQPLEVNRSISIPPPKSISPSILHKPSLESASSTPKISSCSSTPKPFNSKLRAHLPPLSIGSPAVQPLANDNYDSLGVRGLNMELFNDYPGNMHNIKSVLSLEIDIVLGEMDACLKSLECNLLNRKAYNE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
271PhosphorylationIKQYSRMSISELTNV
HHHHHCCCHHHHHHH		23.1225720772
370PhosphorylationTVHEPPSSNDSHPLL
CCCCCCCCCCCCHHH		50.8925720772
373PhosphorylationEPPSSNDSHPLLQLF
CCCCCCCCCHHHHHH		31.1225720772
383PhosphorylationLLQLFKDSKISDDDS
HHHHHCCCCCCCCCC		32.2621712547
386PhosphorylationLFKDSKISDDDSPSN
HHCCCCCCCCCCCCC		38.4321712547
390PhosphorylationSKISDDDSPSNAEGA
CCCCCCCCCCCCCCC		36.9029996109
407PhosphorylationEDSKGEVSYSQIELP
CCCCCCEEEEEEECC		18.1121712547
446PhosphorylationYDLFVGRTRSNSKTS
CCEEEECCCCCCCCC		32.3021712547
448PhosphorylationLFVGRTRSNSKTSSD
EEEECCCCCCCCCCC		44.8621712547
450PhosphorylationVGRTRSNSKTSSDQS
EECCCCCCCCCCCCC		38.2621712547
479PhosphorylationSLGKRGISMSPMKPG
CCCCCCCCCCCCCCC		18.9424763107
481PhosphorylationGKRGISMSPMKPGLR
CCCCCCCCCCCCCCC		18.3021712547
491PhosphorylationKPGLRMPSSFDLQSR
CCCCCCCCCCCCCCC		34.0025720772
499PhosphorylationSFDLQSRSISMGAFE
CCCCCCCCCCCCCHH		25.0229996109
501PhosphorylationDLQSRSISMGAFEQL
CCCCCCCCCCCHHHC		16.6525720772
509PhosphorylationMGAFEQLSTPLEAPA
CCCHHHCCCCCCCCC		27.8929996109
510PhosphorylationGAFEQLSTPLEAPAH
CCHHHCCCCCCCCCC		40.2527738172
533PhosphorylationLEVNRSISIPPPKSI
EEECCCCCCCCCCCC		30.2325720772
539PhosphorylationISIPPPKSISPSILH
CCCCCCCCCCHHHHC		33.7921712547
541PhosphorylationIPPPKSISPSILHKP
CCCCCCCCHHHHCCC		21.4928889911
543PhosphorylationPPKSISPSILHKPSL
CCCCCCHHHHCCCCH		30.8721712547
549PhosphorylationPSILHKPSLESASST
HHHHCCCCHHCCCCC		49.9621712547
552PhosphorylationLHKPSLESASSTPKI
HCCCCHHCCCCCCCC		38.4524763107
554PhosphorylationKPSLESASSTPKISS
CCCHHCCCCCCCCCC		43.9824763107
555PhosphorylationPSLESASSTPKISSC
CCHHCCCCCCCCCCC		48.7429996109
556PhosphorylationSLESASSTPKISSCS
CHHCCCCCCCCCCCC		26.5528889911
561PhosphorylationSSTPKISSCSSTPKP
CCCCCCCCCCCCCCC		22.8425720772
565PhosphorylationKISSCSSTPKPFNSK
CCCCCCCCCCCCCHH		21.0225720772
581PhosphorylationRAHLPPLSIGSPAVQ
HHCCCCCCCCCCCCC		30.5829996109
584PhosphorylationLPPLSIGSPAVQPLA
CCCCCCCCCCCCCCC		14.1725720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NAK1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NAK1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NAK1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HOB1_SCHPOhob1physical
15615784
PMO25_SCHPOpmo25physical
16096637
MOR2_SCHPOmor2physical
16096637
PPK11_SCHPOppk11genetic
20826805
ORB6_SCHPOorb6genetic
22629372
SOG2_SCHPOsog2physical
23394829
MOR2_SCHPOmor2physical
23394829
SOG2_SCHPOsog2physical
23649273
PMO25_SCHPOpmo25physical
23615447
SOG2_SCHPOsog2physical
23462181
CSK2A_SCHPOcka1physical
23462181
CSK2B_SCHPOckb1physical
23462181
CSK2C_SCHPOckb2physical
23462181
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NAK1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-541, AND MASSSPECTROMETRY.

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