MOR2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MOR2_SCHPO
• UniProt AC: Q9HDV6
• Protein Name: Cell polarity protein mor2
• Gene Name: mor2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 2196
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein . Found at the cell tips and at the site of septum formation.
• Protein Description: Required for the maintenance of cell polarity. Has a role in localizing F-actin at the cell tips..
• Protein Sequence: MSLNEIAHDQPVENGPLYSEKQDHTAVDYALHILFTQFVRLSEQKISFLSRYHANEGKNAEPVRFNVGEQEAILLLKKGEDNEFDRCIQALVALASSKPVAVIESLLCWRKVRVDITSSSGTPRVVNERRSSISIYILCRVLTEIAETIPSNALEESTVSCLLECVFHQLLSAKNLPVSSSYFSLANWESFAFLVGSMSRFNFVMVSDRFIEEIEHLEKSGCDSRQKETVLVHLLRAMRYLRLQLYPTTLLEESIAFLQSLTSFFMKANTALKIEYAYLMEQLLRPLISRATFEVNIPAWSRTIETIYPVVLKMCTKTKYWNVFFPFCCTLLCLSPKQFFLKHWISSLDAAFFRVKDRRLRNTGLPHLSRVVWTYSNQYKEEPSIMNSNISNILKSGFSIGKKFSVVPFATLEELDGYAQIVRVVGAHFPELVIKEILTPLSTDAFTENIGPEKLMIVVRSVYYILHDMKYKKSDSTIFEYIEFEFVDLHEVAVGTPLQQFVHNLSQKLLFLVFQLSTNTNCYLDSKNATSLLALYINALKVFPCLMGKLEQRVIDAYVKCLNCSNKIIHTVCHNSLIYFSSGLKMSKSVISCLSRKLVKGSEYLLRTYHEVIRIWISQQEAVIEKRNSVLSNKSCASSESNTPASVKQDYDDIQSWTIIEEIQSLGVLHLSSPSVGIRKFAVALLNDVKQLNTEYLMLSSDKVEVGDIYSEPTIVDVLKDCDSSILSVESHLPTAAERSRLRKFINDGTKDMLLKLATSNSGVDISIWYNVFPRFIKVCFERFPTTMALLRNTVCEKLPSITMQLLSRIESSELNFNLKSAVKNDNFPEFLLVQWKLYLIVACCTITYTSNVDYSHTDLRRTLTAVQSGNHLRGLQETIKITSAESLFSMVLPLIFTEFSPIREAVVFAIGCINVNAFPQLVRSLKPYISVLKQDHQEFIFAGLNFPSVKRRNKPDLLLRSEIAHIFAMTSHLLLHELLNEDREALSVISEFLKDLKGFLSTPNVQADEKYLKLRCYFSQLLEKVLLVQNLHPSSEVLPFSGRASCWKLLDEWTGFGPARAITKNREELMRAHIRGNNKDIRERDKLLASFEAGKQNLEYLAIKAMIALCTAKLQQELTEGVFLFDIEILLNWFTAVFGSPSKAIVGLARKGLTALLLENSSNEVLLQKVINRCFSKEISQTISNYYFLSLSEMLIQINPNNLSKPKLLPLCLVNLSTNNLSVRLKAFELLGNFHLNNFTMTALMEFKTFLESSNPALYLKPQYLFSVQLASDFTEDSFTLTSECLRYFNYGHQHRRGLVTVLLPWLQNLELKMDVENKTFDSFTAVILIDLIEVTAKFTNDLPNEIEALWTSLALSRHKSNWTVILFFLMQQCYQRKTFSFVDCTRQITIYLAKTELLSDLYSTLLSFVCPANVSNENQEVYKFSLEDLSSTYVANLEDLFPSEKNHISYSPCQLSLLLLMDILPNPSIITVTDDVATILHAAFIQFDHYSRIVQEQCQQIFQYVVRKVLAMEGRLDYDDAYFDFNVESSLITGLRGKTKKEDDLVKYHNMILKTIELLSSSYPELKQIWGEVALSWATTCPSRRLACNSFQLFRSLLPDFDARMLLEIISRLVGTISDETSYLRDYSVEILRTFNSYVLVMNSDDLLSYSQILWTAIACLTTIHEDEFIESVKIAYAYFLRVEETDSATQQIMETFPQNWVGDYQGLQILILKGFRSTNSFEITMNFFLLLMDFKDNDLVGVGYLRILSCLLVSLPAMVYTYEHSDPITFDLSVFCHKLATLASQFNDDALIELLDTYLKRKFRSIKDFLKHTVSYLYSYYFEDYELEIVSTLTMFLSNNLTWFRKSTLDVLKELFPLIDFQKPIYSEHGLGIVSPLLRLLPTGYAMEALSLLTDSVLHVSAPTDMQTLKLLMVDPKLKNSDDRLAGFFEIPDEDGWYEPNSEYAAAITKSNVHAVFYSCSTTEASVSTPEVRFHADEVSNYPRHVPTDSHGSLDENSLGELVTTLHSLDVFFAEDRDEELIQPDVAVDPKLDITSEDYDDRIATILSGSLRRQKQGLMAYETESFRDYSPNEEIDASAKLPMDMPPVRVRKSSFISKLKPHYFMDAESYYPSLKALGNSAEHRLSLDEIRGAAELKQNKNWNSMLDQSVSMINEDSVEDHETHENYYHLRTMFQGSESNESFTDTTRSRGWH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLNEIAHD ------CCHHHHCCC	51.73	21712547
629	Phosphorylation	AVIEKRNSVLSNKSC HHHHHHHHHHCCCCC	28.59	21712547
632	Phosphorylation	EKRNSVLSNKSCASS HHHHHHHCCCCCCCC	39.80	24763107
2039	Phosphorylation	DPKLDITSEDYDDRI CCCCCCCCCCCHHHH	28.89	25720772
2073	Phosphorylation	TESFRDYSPNEEIDA CCCCCCCCCCCCCCC	26.07	28889911
2097	Phosphorylation	PVRVRKSSFISKLKP CCEEECHHHHHHCCC	29.63	29996109
2123	Phosphorylation	SLKALGNSAEHRLSL HHHHHCCCHHHCCCH	32.98	29996109
2129	Phosphorylation	NSAEHRLSLDEIRGA CCHHHCCCHHHHHCH	33.46	29996109
2180	Phosphorylation	LRTMFQGSESNESFT HHHHHCCCCCCCCCC	27.37	25720772
2182	Phosphorylation	TMFQGSESNESFTDT HHHCCCCCCCCCCCC	47.82	25720772
2185	Phosphorylation	QGSESNESFTDTTRS CCCCCCCCCCCCCCC	37.38	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MOR2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MOR2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MOR2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WEE1_SCHPO	wee1	genetic	12234926
ORB6_SCHPO	orb6	genetic	12234926
NAK1_SCHPO	nak1	physical	16096637
PMO25_SCHPO	pmo25	physical	16096637
ORB6_SCHPO	orb6	physical	16096637
PPK11_SCHPO	ppk11	genetic	20826805
MOR2_SCHPO	mor2	physical	23615447
POM1_SCHPO	pom1	physical	23615447

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.