dbPTM

WEE1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WEE1_SCHPO
UniProt AC	P07527
Protein Name	Mitosis inhibitor protein kinase wee1
Gene Name	wee1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	877
Subcellular Localization	Nucleus .
Protein Description	Protein kinase that acts both on serines and on tyrosines. It acts as a dosage-dependent negative regulator of entry into mitosis (G2 to M transition). Phosphorylates and inhibits cdc2..
Protein Sequence	MSSSSNTSSHRSYGLRRSQRSMNLNRATLLAPPTPSSLYDANNSTSSTSSQKPNTSFTSLFGPRKQTTSSPSFSHAAPLHPLSPPSFTHSQPQIQAQPVPRRPSLFDRPNLVSRSSSRLGDSPSLSPVAQVANPIHHTAPSPSDVRAFPIHKNASTGVKRSFFSSSMSNGAMSPPSHSPSPFLQSSQHIPPSTPAQKLRKKNNFDSFRISNSHISPFASGSFSPFATSSPNFLSTSTPAPPNSNNANPSTLFSSIPSSRHTTSNHFPSNSAQSSLFSPTARPLTARKLGFASSQTKSAVSNNHSRNSSKDASFMMKSFIPSNRSHPQTQQNESSLFSDNSMVNSSSNSFSLFPNATLPNPPSSELLTTPFQQIKPPSQVFMSTGLLSKQHRPRKNINFTPLPPSTPSKPSTFVRPHSSSTDSPPSPSTPSNTQTDSYFIQRENTPTNHNSIPTIQLEKSSMDFLRFDPPPSAVKTSHNYGLPFLSNQRCPATPTRNPFAFENTVSIHMDGRQPSPIKSRNNNQMSFAMEEEADVSQPSSSSFTLSFPSALTSSKVSSSTSHLLTRFRNVTLLGSGEFSEVFQVEDPVEKTLKYAVKKLKVKFSGPKERNRLLQEVSIQRALKGHDHIVELMDSWEHGGFLYMQVELCENGSLDRFLEEQGQLSRLDEFRVWKILVEVALGLQFIHHKNYVHLDLKPANVMITFEGTLKIGDFGMASVWPVPRGMEREGDCEYIAPEVLANHLYDKPADIFSLGITVFEAAANIVLPDNGQSWQKLRSGDLSDAPRLSSTDNGSSLTSSSRETPANSIIGQGGLDRVVEWMLSPEPRNRPTIDQILATDEVCWVEMRRKAGAIIYEGIHGSSSNPQGDQMMEDWQVNV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
444	Phosphorylation	YFIQRENTPTNHNSI EEEECCCCCCCCCCC	27.08	29996109
450	Phosphorylation	NTPTNHNSIPTIQLE CCCCCCCCCCEEEEE	23.53	28889911
777	Phosphorylation	QSWQKLRSGDLSDAP CCCHHHHCCCCCCCC	47.28	25720772
781	Phosphorylation	KLRSGDLSDAPRLSS HHHCCCCCCCCCCCC	36.14	25720772
788	Phosphorylation	SDAPRLSSTDNGSSL CCCCCCCCCCCCCCC	44.35	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WEE1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WEE1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WEE1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STE20_SCHPO	shk1	genetic	9843966
SKB1_SCHPO	skb1	genetic	9843966
MIK1_SCHPO	mik1	genetic	10947840
KRR1_SCHPO	mis3	genetic	10947840
MPIP_SCHPO	cdc25	genetic	9013342
CG22_SCHPO	cig2	genetic	8972180
DIS3_SCHPO	dis3	genetic	1944266
MPIP_SCHPO	cdc25	genetic	9473044
RUM1_SCHPO	rum1	genetic	9571240
SRW1_SCHPO	srw1	genetic	9398669
RES2_SCHPO	res2	genetic	11029045
HSP90_SCHPO	hsp90	physical	11298745
WOS2_SCHPO	wos2	physical	11298745
CDS1_SCHPO	cds1	physical	9572736
CDK1_SCHPO	cdc2	physical	1850698
CDK1_SCHPO	cdc2	physical	1372994
CDK1_SCHPO	cdc2	physical	7982971
CDS1_SCHPO	cds1	physical	11606526
PUB1_SCHPO	pub1	genetic	8635463
MCS4_SCHPO	mcs4	genetic	9383051
CDK1_SCHPO	cdc2	genetic	3116001
MIK1_SCHPO	mik1	genetic	11809834
PAL1_SCHPO	pal1	genetic	15975911
RHP9_SCHPO	crb2	genetic	20679488
YOX1_SCHPO	yox1	genetic	21132016
KLP5_SCHPO	klp5	genetic	11739790
KLP6_SCHPO	klp6	genetic	11739790
RUM1_SCHPO	rum1	genetic	9013342
PP11_SCHPO	dis2	genetic	1944266
PP12_SCHPO	sds21	genetic	1944266
CHK1_SCHPO	chk1	genetic	10637286
TOR1_SCHPO	tor1	genetic	19546237
SWR1_SCHPO	swr1	genetic	9571240
CG23_SCHPO	cdc13	genetic	9398669
WIN1_SCHPO	win1	genetic	3442828
AMS2_SCHPO	ams2	genetic	18077559
PYP1_SCHPO	pyp1	genetic	1464319
WIS1_SCHPO	wis1	genetic	1756736
CDC14_SCHPO	cdc14	genetic	24006256
CG22_SCHPO	cig2	genetic	8455610
CDK1_SCHPO	cdc2	genetic	24861625
ATF1_SCHPO	atf1	genetic	24728197
RAD3_SCHPO	rad3	genetic	26918805
SPD1_SCHPO	spd1	genetic	26918805
CDS1_SCHPO	cds1	genetic	26918805
CHK1_SCHPO	chk1	genetic	26918805
MPIP_SCHPO	cdc25	genetic	26918805

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WEE1_SCHPO

Related Literatures of Post-Translational Modification