STE20_SCHPO - dbPTM
STE20_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STE20_SCHPO
UniProt AC P50527
Protein Name Serine/threonine-protein kinase shk1/pak1
Gene Name shk1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 658
Subcellular Localization Cytoplasm . Cytoplasm, cytoskeleton, spindle . Localizes at cell ends, septum forming regions and at the mitotic spindle.
Protein Description MAP4K component of the MAPK pathway required for the mating pheromone response. Phosphorylates histone H2B to form H2BS10ph (By similarity). Phosphorylates tea1. Required for skb1-dependent mitotic inhibitory function. Regulates microtubule dynamics and cell polarity..
Protein Sequence MERGTLQPRKKAPNGYGITPIVAHKTGEPVRYEVEDDLRKLKPSRTAPKPPAINTNLAEDTFSGFPLSQSRTTVSRVSLGSRQHSSSSIRKLQTNVSDVRSYDERNQKKSAFENFVSSMSSFLTGGGSSPTSSYGSGSASPRKSTVISSPFDPKHVTHVGFNYDTGEFTGMPTEWQALLKVSGITKSEQVQHPQAVLDAMAFYSQSKKYLEEGAKPPFPRESTEKPLLSVSALSSSSHLQPTSATSSSSRLYPSRPAPTPPASSSSSPLLSSQTVKTTTSNASRQPSPLVSSKSTDNIIRSHSPVLLTPQTLSTSETKHIRPNNSTPYQRRAETSTKPKAVATPQKVEAPSAPRLQKRAPRQQSNDSAVLAKLQSICNPKNPTLLYRNFVKIGQGASGDVYSARQVGTNLSVAIKKMNINQQPKKEFIVNEILVMKSHHHKNIVNFIDTFFYKSELWMVMEYMRGGSLTEVVTNNTLSEGQIAAICKETLEGLQHLHENGIVHRDIKSDNILLSLQGDIKLTDFGFCAQIDSNMTKRTTMVGTPYWMAPEVVTRKEYGFKVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATIGTPKISRPELLSSVFHDFLSKSLTVNPKQRPSSGELLRHPFLKQAVPVSSLIPLIKSIHHSGK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26PhosphorylationTPIVAHKTGEPVRYE
CCEEEECCCCCEEEE		36.5924763107
32PhosphorylationKTGEPVRYEVEDDLR
CCCCCEEEEEHHHHH		25.2621712547
72PhosphorylationFPLSQSRTTVSRVSL
CCCCCCCCEEEEEEE		36.4725720772
73PhosphorylationPLSQSRTTVSRVSLG
CCCCCCCEEEEEEEC		18.5125720772
75PhosphorylationSQSRTTVSRVSLGSR
CCCCCEEEEEEECCC		25.5229996109
78PhosphorylationRTTVSRVSLGSRQHS
CCEEEEEEECCCCCC		26.3829996109
81PhosphorylationVSRVSLGSRQHSSSS
EEEEEECCCCCCHHH		33.7825720772
94PhosphorylationSSIRKLQTNVSDVRS
HHHHHHHHCHHHHHC		48.2824763107
97PhosphorylationRKLQTNVSDVRSYDE
HHHHHCHHHHHCHHH		32.2421712547
101PhosphorylationTNVSDVRSYDERNQK
HCHHHHHCHHHHHHH		36.4621712547
102PhosphorylationNVSDVRSYDERNQKK
CHHHHHCHHHHHHHH		15.9721712547
128PhosphorylationSFLTGGGSSPTSSYG
HHHCCCCCCCCCCCC		36.1021712547
136PhosphorylationSPTSSYGSGSASPRK
CCCCCCCCCCCCCCC		22.7221712547
144PhosphorylationGSASPRKSTVISSPF
CCCCCCCCCEECCCC		29.2324763107
145PhosphorylationSASPRKSTVISSPFD
CCCCCCCCEECCCCC		25.5429996109
187PhosphorylationKVSGITKSEQVQHPQ
HHHCCCCHHHCCCHH		25.3124763107
287PhosphorylationSNASRQPSPLVSSKS
CCCCCCCCCCCCCCC		23.6427738172
294PhosphorylationSPLVSSKSTDNIIRS
CCCCCCCCCCCHHHC		42.8321712547
295PhosphorylationPLVSSKSTDNIIRSH
CCCCCCCCCCHHHCC		36.4825720772
301PhosphorylationSTDNIIRSHSPVLLT
CCCCHHHCCCCEEEC		20.2228889911
303PhosphorylationDNIIRSHSPVLLTPQ
CCHHHCCCCEEECCC		20.2528889911
308PhosphorylationSHSPVLLTPQTLSTS
CCCCEEECCCCCCCC		14.8021712547
311PhosphorylationPVLLTPQTLSTSETK
CEEECCCCCCCCCCC		24.7125720772
313PhosphorylationLLTPQTLSTSETKHI
EECCCCCCCCCCCCC		33.0225720772
325PhosphorylationKHIRPNNSTPYQRRA
CCCCCCCCCCCCHHC		37.0829996109
343PhosphorylationTKPKAVATPQKVEAP
CCCCCCCCCCCCCCC		21.4729996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of STE20_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STE20_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STE20_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SHK2_SCHPOshk2genetic
9660818
SHK2_SCHPOshk2genetic
9660817
ORB6_SCHPOorb6genetic
9636183
TEA1_SCHPOtea1genetic
12764130
RGA8_SCHPOrga8genetic
14506270
RHO1_SCHPOrho1genetic
14506270
TEA1_SCHPOtea1genetic
11972773
SKB5_SCHPOskb5genetic
10593886
SKB15_SCHPOskb15physical
11389855
CDK1_SCHPOcdc2physical
9843966
SKB1_SCHPOskb1physical
8943016
STE20_SCHPOshk1physical
8943016
CDC42_SCHPOcdc42physical
8943016
RGA8_SCHPOrga8physical
14506270
CDC42_SCHPOcdc42physical
12409291
SCD2_SCHPOscd2physical
12409291
SKB5_SCHPOskb5physical
10593886
CDC42_SCHPOcdc42physical
9858584
STE20_SCHPOshk1physical
9858584
CDC42_SCHPOcdc42physical
8846783
SCD2_SCHPOscd2physical
10567532
TEA1_SCHPOtea1physical
12764130
STE20_SCHPOshk1physical
11389855
STE20_SCHPOshk1physical
10567532
CDC42_SCHPOcdc42physical
10567532
BYR2_SCHPObyr2genetic
9660817
GEF1_SCHPOgef1genetic
12529446
SCD1_SCHPOscd1genetic
12529446
SCD2_SCHPOscd2genetic
10567532
FLP1_SCHPOclp1physical
23297348
STE20_SCHPOshk1physical
23615447
SCD2_SCHPOscd2physical
23615447
SKB1_SCHPOskb1physical
23615447
SKB5_SCHPOskb5physical
23615447
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STE20_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301 AND SER-303, ANDMASS SPECTROMETRY.

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