| UniProt ID | TEA1_SCHPO | |
|---|---|---|
| UniProt AC | P87061 | |
| Protein Name | Tip elongation aberrant protein 1 | |
| Gene Name | tea1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 1147 | |
| Subcellular Localization | Cytoplasm, cytoskeleton . Present at both poles of the cell throughout the cell cycle whether they are growing or not. Located at the ends of microtubules growing towards the cell poles. An intact microtubular skeleton is required to maintain the loc | |
| Protein Description | Cell polarity protein. Acts as an end marker, directing the growth machinery to the cell poles. Involved in the regulation of microtubular organization, affecting the maintenance of a single central axis. Prevents the curling of microtubule tips around the cell ends and is required for the retention of polarity factors such as pom1, tip1 and tea2 at the cell ends, necessary for the cell to grow in a straight line. Links tip1 and tea4 in a common complex.. | |
| Protein Sequence | MSFLFKRNKGSAHKPTKPNFSKTSTTPSTSQLKHSHESNVKMSTSTVTEHRKKPTGSGSHITASPWSKLTVRGSSNVLPRYSHASHLYAEGGQEIYIFGGVASDSQPKNDLWVLNLATSQFTSLRSLGETPSPRLGHASILIGNAFIVFGGLTNHDVADRQDNSLYLLNTSSLVWQKANASGARPSGRYGHTISCLGSKICLFGGRLLDYYFNDLVCFDLNNLNTSDSRWELASVVNDPPPARAGHVAFTFSDKLYIFGGTDGANFFNDLWCYHPKQSAWSKVETFGVAPNPRAGHAASVVEGILYVFGGRASDGTFLNDLYAFRLSSKHWYKLSDLPFTPSPRSSHTLSCSGLTLVLIGGKQGKGASDSNVYMLDTSRFRLGSVPTTSGRQRNTSFFSNSTGNTNPSAFNGLLTSSRIPSYNGSKVRSTSHPSRQQYIGSSNSRFNTRHQTISTPVSGRASNDLPSPVVPTRSNSSSILQPSYNLNSHSSDRRNTNDDDQSSLNSQQLSNQAKAQGEVSPTLSFVPSSHSMEQGNGSVASANNAQSEAATRSINSISEVSEVRFPEQSSVKTVDERKSLDGRITSVTLETLVEKYSELSKQQIVEWFKSKLYEILRDSASKIDSLTEKLKVANAEKNAALCEAALEKVPLAKHNKLSDGTFSTPDKENVQSTNDAHIMQENFSLHKALEVMRETSSDLDKQLKDATASQKELIVQTSSFQKELVEERERHNAISKRLQEIESLYRDRELLVTNLEDQLVDQTVTINKFAFERDQFRERSMGFENTIKDLTRKMEATDMLNVSLHESLRSVQTENSELVTEMALLKAELVKKQAIIDANANIYDKLTADHTNYETVSADINQNLKETLDKLLNGSSDFKNNEIELLHDQIRITNAKLEKREKLINASKYIEDTLRSEIQEAAEKVSNLEFSNFNLKEENSNMQLQLMKALEQRNTGAKQLVNLRMQLSTATSELDMLKLKLRTTALALEESPDDYSDILSILRADMSPFHDLHKQCGVLIDTLNGVKRGFGIFEKKFTDYHKFLENISDKLKSEEDTSLETPIHENQSIQSDQIKEVGEVLSAIKSLSDSVMLLKNQIDDLAKEKLPLSSSDDEKVNIKEKTDFMKLLVKSGLSNPPAKEPVHDNEN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 452 | Phosphorylation | RFNTRHQTISTPVSG CCCCCCCEECCCCCC | 15.69 | 29996109 | |
| 455 | Phosphorylation | TRHQTISTPVSGRAS CCCCEECCCCCCCCC | 24.69 | 29996109 | |
| 458 | Phosphorylation | QTISTPVSGRASNDL CEECCCCCCCCCCCC | 24.62 | 29996109 | |
| 462 | Phosphorylation | TPVSGRASNDLPSPV CCCCCCCCCCCCCCC | 29.52 | 25720772 | |
| 467 | Phosphorylation | RASNDLPSPVVPTRS CCCCCCCCCCCCCCC | 37.31 | 28889911 | |
| 474 | Phosphorylation | SPVVPTRSNSSSILQ CCCCCCCCCCCCCCC | 43.47 | 29996109 | |
| 476 | Phosphorylation | VVPTRSNSSSILQPS CCCCCCCCCCCCCCC | 27.06 | 29996109 | |
| 496 | Phosphorylation | HSSDRRNTNDDDQSS CCCCCCCCCCCCHHH | 37.91 | 25720772 | |
| 502 | Phosphorylation | NTNDDDQSSLNSQQL CCCCCCHHHHHHHHH | 43.73 | 29996109 | |
| 503 | Phosphorylation | TNDDDQSSLNSQQLS CCCCCHHHHHHHHHH | 26.41 | 28889911 | |
| 506 | Phosphorylation | DDQSSLNSQQLSNQA CCHHHHHHHHHHHHH | 25.29 | 25720772 | |
| 510 | Phosphorylation | SLNSQQLSNQAKAQG HHHHHHHHHHHHHCC | 23.66 | 25720772 | |
| 553 | Phosphorylation | QSEAATRSINSISEV HHHHHHHHCCCCHHC | 23.05 | 29996109 | |
| 556 | Phosphorylation | AATRSINSISEVSEV HHHHHCCCCHHCCCC | 26.31 | 28889911 | |
| 558 | Phosphorylation | TRSINSISEVSEVRF HHHCCCCHHCCCCCC | 31.59 | 29996109 | |
| 561 | Phosphorylation | INSISEVSEVRFPEQ CCCCHHCCCCCCCCC | 26.73 | 25720772 | |
| 579 | Phosphorylation | KTVDERKSLDGRITS CCHHHCCCCCCCCEE | 37.60 | 24763107 | |
| 585 | Phosphorylation | KSLDGRITSVTLETL CCCCCCCEEEEHHHH | 18.78 | 25720772 | |
| 586 | Phosphorylation | SLDGRITSVTLETLV CCCCCCEEEEHHHHH | 15.67 | 21712547 | |
| 588 | Phosphorylation | DGRITSVTLETLVEK CCCCEEEEHHHHHHH | 20.74 | 21712547 | |
| 658 | Phosphorylation | LAKHNKLSDGTFSTP CCCCCCCCCCCCCCC | 35.29 | 21712547 | |
| 664 | Phosphorylation | LSDGTFSTPDKENVQ CCCCCCCCCCHHHCC | 31.17 | 24763107 | |
| 1061 | Phosphorylation | EEDTSLETPIHENQS CCCCCCCCCCCCCCC | 32.60 | 24763107 | |
| 1068 | Phosphorylation | TPIHENQSIQSDQIK CCCCCCCCCCHHHHH | 33.89 | 21712547 | |
| 1071 | Phosphorylation | HENQSIQSDQIKEVG CCCCCCCHHHHHHHH | 29.79 | 28889911 | |
| 1109 | Phosphorylation | AKEKLPLSSSDDEKV HHCCCCCCCCCCCCC | 26.34 | 21712547 | |
| 1111 | Phosphorylation | EKLPLSSSDDEKVNI CCCCCCCCCCCCCCH | 45.78 | 21712547 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TEA1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TEA1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TEA1_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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