TEA3_SCHPO - dbPTM
TEA3_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TEA3_SCHPO
UniProt AC O14248
Protein Name Tip elongation aberrant protein 3
Gene Name tea3
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1125
Subcellular Localization Cell tip . Cell septum . Present at both poles of the cell throughout the cell cycle whether they are growing or not. Located at the septum at time of cytokinesis.
Protein Description Acts as a cell end marker required for efficient new end take-off (NETO), whereby growth is activated at the cell end to generate bipolarity in extending cells. Also required for proper placement of the septum..
Protein Sequence MVQKVLSRQSDNSQDVSAEQLDVVESGSIDQQNIRAWVVRKVKENDKRTSTNQSFKWEAVKPASCLDAANEKFMYLHGGREKSGISNSLFKLDLDSCTVYSHNRGEDNDSPARVGHSIVCSADTIYLFGGCDSETDSTFEVGDNSLYAYNFKSNQWNLVSTQSPLPSPRTGHSMLLVDSKLWIFGGECQGKYLNDIHLFDTKGVDRRTQSELKQKANANNVEKANMEFDETDWSWETPFLHSSSPPPRSNHSVTLVQGKIFVHGGHNDTGPLSDLWLFDLETLSWTEVRSIGRFPGPREGHQATTIDDTVYIYGGRDNKGLILNELWAFNYSQQRWSLVSNPIPILLSDSSSYKIVSKNNHILLLYLNALDAPKQLLCYEADPKNLYWDKDKFSDIPVLQHISMKPSNASNHTVSLGYLNDRPNHSKKNSVTSTSSSQFNNFLEQNQKAVRSARHRHYASLDEQGLHSLRNLSKTSGMNHSADFSLHEFGQADPFAYEIEKPIASLPLPNGNDTISRSSESSSPINESESNSLLKLQSDFKFSNSDDRVAWLEEQLLYCMQQGYTLKPPNLFQHVDEKLRLEKKEQLSYLEILKVIEQMLESNEQKFKKQIVSLASENAKLAAQRDAAVENANYSRSLIQKKTTDETVGSLIEKVGKLEYEVQGTLEEATSYYQKNTELQQLLKQNESASELLKSRNEKLCVDYDKLRSVFEEDSSKILSLQKENENLQSQILQISEELVDYRSRCEALEYGNYELETKLIEMHDRVEMQTNVIEASASALDVSNTAILSFEDSLRRERDEKSTLQQKCLNLQYEYENVRIELENLQSRALELESALEQSVSDAKYSKAIMQSGLSKLLSSINENKDNLKEFSKSKQKISYLESQLEGLHELLRESQRLCEGRTKELLNSQQKLYDLKHSYSSVMTEKSKLSDQVNDLTEQAKITQRKLSEVQIALADSKMNQQLSGKDSTDVHLPTDFSASSSPLRSYFNEEDSFNNASAAHSSKESDIPSGGVFTKYRNHFGNLMTSEETKAPDNNDLHKRLSDVINSQQKFLSLSPQVSKDYYDVRSKLNDTAGSFSGEEMRAIDDNYYASRIKQLEDDYQKAITYANCSDESFQQLSHSFM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
179PhosphorylationHSMLLVDSKLWIFGG
CCEEEECCEEEEECC		23.3628889911
407PhosphorylationQHISMKPSNASNHTV
EEEEECCCCCCCCEE		39.2421712547
410PhosphorylationSMKPSNASNHTVSLG
EECCCCCCCCEEEEE		33.1321712547
413PhosphorylationPSNASNHTVSLGYLN
CCCCCCCEEEEEEEC		18.9521712547
415PhosphorylationNASNHTVSLGYLNDR
CCCCCEEEEEEECCC		19.7521712547
426PhosphorylationLNDRPNHSKKNSVTS
ECCCCCCCCCCCCCC		52.5521712547
430PhosphorylationPNHSKKNSVTSTSSS
CCCCCCCCCCCCCHH		35.3328889911
432PhosphorylationHSKKNSVTSTSSSQF
CCCCCCCCCCCHHHH		26.5524763107
433PhosphorylationSKKNSVTSTSSSQFN
CCCCCCCCCCHHHHH		24.9224763107
434PhosphorylationKKNSVTSTSSSQFNN
CCCCCCCCCHHHHHH		24.2221712547
435PhosphorylationKNSVTSTSSSQFNNF
CCCCCCCCHHHHHHH		27.9721712547
436PhosphorylationNSVTSTSSSQFNNFL
CCCCCCCHHHHHHHH		28.3921712547
437PhosphorylationSVTSTSSSQFNNFLE
CCCCCCHHHHHHHHH		38.2628889911
460PhosphorylationARHRHYASLDEQGLH
HHHHHCCCCCHHHHH		29.2328889911
468PhosphorylationLDEQGLHSLRNLSKT
CCHHHHHHHHHHHCC		33.7829996109
481PhosphorylationKTSGMNHSADFSLHE
CCCCCCCCCCCCHHH		25.2421712547
485PhosphorylationMNHSADFSLHEFGQA
CCCCCCCCHHHCCCC		29.3921712547
523PhosphorylationSRSSESSSPINESES
CCCCCCCCCCCHHHC		38.7928889911
688PhosphorylationQLLKQNESASELLKS
HHHHCCCCHHHHHHH		44.6528889911
922PhosphorylationYDLKHSYSSVMTEKS
HHHHHHHHHHHHCHH		21.3324763107
950PhosphorylationKITQRKLSEVQIALA
HHHHHHHHHHHHHHH		38.4628889911
977PhosphorylationSTDVHLPTDFSASSS
CCCCCCCCCCCCCCC		56.9125720772
980PhosphorylationVHLPTDFSASSSPLR
CCCCCCCCCCCCCHH		30.0128889911
982PhosphorylationLPTDFSASSSPLRSY
CCCCCCCCCCCHHHH		30.1028889911
983PhosphorylationPTDFSASSSPLRSYF
CCCCCCCCCCHHHHC		35.3728889911
984PhosphorylationTDFSASSSPLRSYFN
CCCCCCCCCHHHHCC		26.0128889911
988PhosphorylationASSSPLRSYFNEEDS
CCCCCHHHHCCCCCC		41.5821712547
989PhosphorylationSSSPLRSYFNEEDSF
CCCCHHHHCCCCCCC		12.1827738172
995PhosphorylationSYFNEEDSFNNASAA
HHCCCCCCCCCCHHH		32.9029996109
1000PhosphorylationEDSFNNASAAHSSKE
CCCCCCCHHHCCCCC		28.2825720772
1004PhosphorylationNNASAAHSSKESDIP
CCCHHHCCCCCCCCC		38.0825720772
1005PhosphorylationNASAAHSSKESDIPS
CCHHHCCCCCCCCCC		30.4925720772
1008PhosphorylationAAHSSKESDIPSGGV
HHCCCCCCCCCCCCH		44.5729996109
1045PhosphorylationNDLHKRLSDVINSQQ
CHHHHHHHHHHHHHH		33.5928889911
1050PhosphorylationRLSDVINSQQKFLSL
HHHHHHHHHHHHHHC		23.9021712547
1056PhosphorylationNSQQKFLSLSPQVSK
HHHHHHHHCCCCCCH		29.9021712547
1058PhosphorylationQQKFLSLSPQVSKDY
HHHHHHCCCCCCHHH		15.2028889911
1062PhosphorylationLSLSPQVSKDYYDVR
HHCCCCCCHHHHHHH		17.9824763107
1070PhosphorylationKDYYDVRSKLNDTAG
HHHHHHHHHHHCCCC		41.1524763107
1075PhosphorylationVRSKLNDTAGSFSGE
HHHHHHCCCCCCCHH		31.6721712547
1078PhosphorylationKLNDTAGSFSGEEMR
HHHCCCCCCCHHHHH		17.4928889911
1080PhosphorylationNDTAGSFSGEEMRAI
HCCCCCCCHHHHHHH		47.1728889911
1091PhosphorylationMRAIDDNYYASRIKQ
HHHHCCCHHHHHHHH		13.8521712547
1109PhosphorylationDYQKAITYANCSDES
HHHHHHHHCCCCHHH		6.9525720772
1113PhosphorylationAITYANCSDESFQQL
HHHHCCCCHHHHHHH		44.1925720772
1116PhosphorylationYANCSDESFQQLSHS
HCCCCHHHHHHHHHH		33.0925720772
1121PhosphorylationDESFQQLSHSFM---
HHHHHHHHHHCC---		16.8527738172
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TEA3_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TEA3_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TEA3_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
POM1_SCHPOpom1genetic
12007420
TEA1_SCHPOtea1physical
16222337
TEA3_SCHPOtea3physical
26771498
MUG79_SCHPOspo7physical
26771498
ATG11_SCHPOatg11physical
26771498
MCM10_SCHPOcdc23physical
26771498
YH7G_SCHPOSPBC16G5.16physical
26771498
SIM4_SCHPOsim4physical
26771498
CWC16_SCHPOsaf4physical
26771498
VPS20_SCHPOvps20physical
26771498
MCP5_SCHPOmcp5physical
26771498
LTN1_SCHPOrkr1physical
26771498
CDC10_SCHPOcdc10physical
26771498
GYP1_SCHPOgyp1physical
26771498
MCP6_SCHPOmcp6physical
26771498
RRN11_SCHPOrrn11physical
26771498
DHH1_SCHPOste13physical
26771498
YHP4_SCHPOrmn1physical
26771498
BIS1_SCHPObis1physical
26771498
HOS3_SCHPOdad5physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TEA3_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-430; SER-437; SER-460;SER-523; SER-980; SER-982; SER-983; SER-984; SER-1078 AND SER-1080,AND MASS SPECTROMETRY.

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