GYP1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GYP1_SCHPO
• UniProt AC: O59737
• Protein Name: GTPase-activating protein gyp1
• Gene Name: gyp1 {ECO:0000312|EMBL:CAA19167.1}
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 514
• Subcellular Localization: Golgi apparatus, Golgi stack . Cytoplasm . Nucleus .
• Protein Description: Stimulates specifically the GTPase activity of ypt1. Functions on the Golgi as a negative regulator of ypt1 (By similarity)..
• Protein Sequence: MESQSKKSSALKTLSSLWNGSSSATSDPVTVLDRSRTHHHRGRSTSSKAQPFRLDDSVYSDQPPKDHISLARSITRPESASESKIYAPSARSSLSLEAVVGKKVSAKFAKYLSQTDDDWGVSNIKASKSLPRMARSTTPNSSSRSLFPQNGVDTTTSRQKLHSSGRFPLPAKLAHRSVEVEVAESNALVSRIKKFSRILDAPIVDLNALRTLAWNGIPSEHRPIVWKYLLGYLPCNASRREVTLKRKRDEYNAAKDSCFNTNTEPPPLDQTIWRQIVLDVPRTNPSILLYQNPLTQRMLERILYVWASRHPASGYVQGISDLVTPFIQVFLSEYIGDKDPMTYDIALLDETNRNDIEADAYWCLSKLLDGIQDNYIHAQPGIRRQVNNLRELTLRIDEPLVKHLQMEGVDFLQFSFRWMNCLLMRELSISNIIRMWDTYMAEGVQGFSEFHLYVCAAFLVKWSSELQKMEFQDILIFLQSIPTKDWSTKDIEILLSEAFLWKSLYSGAGAHLKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Phosphorylation	QPPKDHISLARSITR CCCCCCCCHHHHCCC	16.74	21712547
73	Phosphorylation	DHISLARSITRPESA CCCCHHHHCCCCCCC	23.78	25720772
75	Phosphorylation	ISLARSITRPESASE CCHHHHCCCCCCCCC	41.22	24763107
79	Phosphorylation	RSITRPESASESKIY HHCCCCCCCCCCCCC	39.51	29996109
81	Phosphorylation	ITRPESASESKIYAP CCCCCCCCCCCCCCC	52.24	29996109
83	Phosphorylation	RPESASESKIYAPSA CCCCCCCCCCCCCCC	23.12	29996109
89	Phosphorylation	ESKIYAPSARSSLSL CCCCCCCCCCCCCCH	28.30	21712547
92	Phosphorylation	IYAPSARSSLSLEAV CCCCCCCCCCCHHHH	35.03	25720772
93	Phosphorylation	YAPSARSSLSLEAVV CCCCCCCCCCHHHHH	19.20	21712547
95	Phosphorylation	PSARSSLSLEAVVGK CCCCCCCCHHHHHCC	26.55	21712547
138	Phosphorylation	PRMARSTTPNSSSRS CCHHCCCCCCCCCCC	23.01	27738172
483	Phosphorylation	IFLQSIPTKDWSTKD HHHHCCCCCCCCHHH	39.71	27738172

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GYP1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GYP1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GYP1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EFC25_SCHPO	efc25	genetic	18931302
UBC15_SCHPO	ubc15	genetic	19547744
SEC6_SCHPO	sec6	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.