EFC25_SCHPO - dbPTM
EFC25_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EFC25_SCHPO
UniProt AC Q9USU1
Protein Name Ras guanine nucleotide exchange factor efc25
Gene Name efc25
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 987
Subcellular Localization Cytoplasm .
Protein Description Has a role in chromosome segregation and cell morphology upstream of the ras1-scd1 pathway. Promotes the exchange of ras1-bound GDP by GTP leading to its activation..
Protein Sequence MRRPNLDRLRLKSRQGFETSVSKPSTPSYSTYSLSPTFSDKSVLSPSTMSDSYALSSTYTAGSSYQNGESDYFGSLPTPSSDKSSTSPFPYLKGSFDDRFSSTHSLTRQPSPRSPLTPLKGNTRASPEIRYVSDFTPPSSPFEDMQASVHSLPLSGCSIGPVRTNHSSSLSNSSNSLLQTESSLRPNSSFVNSPFFPLPSSDDLFLNDRVINLFLFYEKFSYLFTHLLSAIKSRDALSIPSLVLSLQEELFNLCQQTGTFYLLQHNLLQNFEFENPIKLHFDKIIPYFSRLTVLTFSNRAFIFPDHTFPRLQQSAEDFLYHLQFFFTLCANNSLYLSRFCYYPSFVPNTPFGGKWTNNGLSAVSSAYRTRLLEPCLPELDKCVWFLLKNCDEFIENFSDFADEEYVFEICSTITSHSEQIFNKLESWDMSIYFDKDLSECEQATNFAVQSYFVTKQRCYDLLTDLVCSSQDLMMEHSNDFSTMPTMIASIAVAFQTLFENVCDFLKVRAALVDEMQELATKEFENKFSNANTAKDDEPARQTNKGTTRISRSSDFTAVSEMSKDTLTLGRNSLQSILMLDNLLTNKVVQSDNNVKGGTLPALVHYLVQNVHLNKDFRHSFLLTYKTFTTPQELFTLLVILFHELPPPGLDATAYSSWEKGDNFVTKKNVCTVMNLWVQKYFFEDLKARNTLYLISEMRTFLRDHVVPSFHIGSVILSEIDNLWTEEPPDSLTQRLLSSPMATFISLNVYAYTPEEFASQMTLLEFDYLKQIPSREWIFRSWVSRDSRSAVRNYINFSNCFTYWIINCILEKKNTKARTAVISFFIQTAYKCLSLQNFSTLMSIVSALNSAPIYRLHAAYKLVKAEDIICLSGLREIVETKKNFSTYRALLRKAELPCVPFLGVILSDLTFIDEGNPDVLDSSPHLLSFNKRHRLADVVADVCRFQSSSYEMQSNTDLQSYILHRCRFVNQDLSYLFDKSLSLEPRSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
87PhosphorylationSSDKSSTSPFPYLKG
CCCCCCCCCCCCCCC		26.8725720772
91PhosphorylationSSTSPFPYLKGSFDD
CCCCCCCCCCCCCCC		22.7925720772
101PhosphorylationGSFDDRFSSTHSLTR
CCCCCCCCCCCCCCC		34.9125720772
102PhosphorylationSFDDRFSSTHSLTRQ
CCCCCCCCCCCCCCC		27.6825720772
103PhosphorylationFDDRFSSTHSLTRQP
CCCCCCCCCCCCCCC		17.8125720772
105PhosphorylationDRFSSTHSLTRQPSP
CCCCCCCCCCCCCCC		31.3725720772
107PhosphorylationFSSTHSLTRQPSPRS
CCCCCCCCCCCCCCC		30.2125720772
111PhosphorylationHSLTRQPSPRSPLTP
CCCCCCCCCCCCCCC		25.3025720772
114PhosphorylationTRQPSPRSPLTPLKG
CCCCCCCCCCCCCCC		27.8729996109
117PhosphorylationPSPRSPLTPLKGNTR
CCCCCCCCCCCCCCC		29.9329996109
123PhosphorylationLTPLKGNTRASPEIR
CCCCCCCCCCCCCCE		35.9625720772
126PhosphorylationLKGNTRASPEIRYVS
CCCCCCCCCCCEEEC		21.5625720772
426PhosphorylationQIFNKLESWDMSIYF
HHHHHHHHCCEEEEE		38.5224763107
430PhosphorylationKLESWDMSIYFDKDL
HHHHCCEEEEECCCH		16.2124763107
552PhosphorylationGTTRISRSSDFTAVS
CCCCEECCCCCCCEE		27.7128889911
553PhosphorylationTTRISRSSDFTAVSE
CCCEECCCCCCCEEC		35.3225720772
565PhosphorylationVSEMSKDTLTLGRNS
EECCCCCCEECCHHH		25.9421712547
567PhosphorylationEMSKDTLTLGRNSLQ
CCCCCCEECCHHHHH		29.2921712547
572PhosphorylationTLTLGRNSLQSILML
CEECCHHHHHHHHHH		26.8221712547
575PhosphorylationLGRNSLQSILMLDNL
CCHHHHHHHHHHHHH		24.0021712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EFC25_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EFC25_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EFC25_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TEA1_SCHPOtea1genetic
12052869
TEA2_SCHPOtea2genetic
18931302
MAL3_SCHPOmal3genetic
18931302
ASL1_SCHPOasl1genetic
22681890
YCJ3_SCHPOSPCC63.03genetic
22681890
YEG5_SCHPOmga2genetic
22681890
YNVD_SCHPOfar10genetic
22681890
YGD1_SCHPOfar8genetic
22681890
YFY2_SCHPOSPAC9.02cgenetic
22681890
TWF1_SCHPOtwf1genetic
22681890
MGR2_SCHPOmgr2genetic
22681890
NEM1_SCHPOnem1genetic
22681890
UAF30_SCHPOspp27genetic
22681890
MBO1_SCHPOmto1genetic
22681890
YHP6_SCHPOmto2genetic
22681890
MAL3_SCHPOmal3genetic
22681890
POM1_SCHPOpom1genetic
22681890
FT105_SCHPOftp105genetic
22681890
TEA2_SCHPOtea2genetic
22681890
PTR2_SCHPOptr2genetic
22681890
ROK1_SCHPOrok1genetic
22681890
ERD11_SCHPOerd1genetic
22681890
SHR3_SCHPOpsh3genetic
22681890
YHZ3_SCHPOath1genetic
22681890
ZYM1_SCHPOzym1genetic
22681890
TIP1_SCHPOtip1genetic
22681890
SPN1_SCHPOspn1genetic
22681890
MID1_SCHPOmid1genetic
22681890
YFE6_SCHPOgmh5genetic
22681890
PRZ1_SCHPOprz1genetic
22681890
CSK1_SCHPOcsk1genetic
22681890
MKH1_SCHPOmkh1genetic
22681890
ATC1_SCHPOpmr1genetic
22681890
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EFC25_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552, AND MASSSPECTROMETRY.

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