TIP1_SCHPO - dbPTM
TIP1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TIP1_SCHPO
UniProt AC P79065
Protein Name Tip elongation protein 1
Gene Name tip1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 461
Subcellular Localization Cytoplasm, cytoskeleton . Located at the microtubule tips.
Protein Description Has a role in stabilizing and targeting the growing tips of the microtubules along the long axis of the cell, directing them to the ends of the cell. Acts as a cargo for tea2..
Protein Sequence MFPLGSVVEVITGERGFVRYAGEVENRKGVYVGLELLPEFAEFGKNRGVVDGREYFKTKNNEKTGIFVPFDKCKLASSISSSPSPKIDGTAASIGMGFPPMSPNLQSSIPRLTNVSSSSNLSMNTISSTALTPTEKILQKRIEDLLYERQNHQQQLEEVLATVDQLQSLVTNFNDQQDEVDELRERITLKEERIQQMRNEASQRRFEFKTTIECLEESSNRAIETYENRIAELEAQLEMYMSGKSEDDLLFSLQQERDYALNQVEILQERVDTLMKQKANSSTANEKLSHMESSSPTLTNASFESPKRGKGSNDLPENHPQRRQTLEFYEIEIEVLREKVEKLQALSDEKDFYISKLEKSLDRNDTTPVPSDEKLSNYAAEKENLVSRISELEHTIEQLTINNERDNERMSPAEFELETTQEVEENDSDSHDDEETWCEVCETNNHSLQECPTVFGSTDEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
77PhosphorylationFDKCKLASSISSSPS
CCHHHCCHHCCCCCC		38.3421712547
78PhosphorylationDKCKLASSISSSPSP
CHHHCCHHCCCCCCC		22.3825720772
80PhosphorylationCKLASSISSSPSPKI
HHCCHHCCCCCCCCC		27.0625720772
81PhosphorylationKLASSISSSPSPKID
HCCHHCCCCCCCCCC		44.6025720772
82PhosphorylationLASSISSSPSPKIDG
CCHHCCCCCCCCCCC		23.7028889911
84PhosphorylationSSISSSPSPKIDGTA
HHCCCCCCCCCCCCC		40.5528889911
102PhosphorylationGMGFPPMSPNLQSSI
CCCCCCCCCCHHHCC		19.1929996109
117PhosphorylationPRLTNVSSSSNLSMN
CCCCCCCCCCCCCCC		33.2427738172
289PhosphorylationSTANEKLSHMESSSP
CHHHHHHHCCCCCCC		31.6828889911
293PhosphorylationEKLSHMESSSPTLTN
HHHHCCCCCCCCCCC		28.6525720772
294PhosphorylationKLSHMESSSPTLTNA
HHHCCCCCCCCCCCC		27.3428889911
295PhosphorylationLSHMESSSPTLTNAS
HHCCCCCCCCCCCCC		31.0528889911
297PhosphorylationHMESSSPTLTNASFE
CCCCCCCCCCCCCCC		48.4328889911
299PhosphorylationESSSPTLTNASFESP
CCCCCCCCCCCCCCC		31.0829996109
302PhosphorylationSPTLTNASFESPKRG
CCCCCCCCCCCCCCC		31.4528889911
305PhosphorylationLTNASFESPKRGKGS
CCCCCCCCCCCCCCC		33.4428889911
312PhosphorylationSPKRGKGSNDLPENH
CCCCCCCCCCCCCCC		30.5629996109
360PhosphorylationYISKLEKSLDRNDTT
HHHHHHHHCCCCCCC		26.5721712547
366PhosphorylationKSLDRNDTTPVPSDE
HHCCCCCCCCCCCHH		36.2321712547
367PhosphorylationSLDRNDTTPVPSDEK
HCCCCCCCCCCCHHH		25.7528889911
371PhosphorylationNDTTPVPSDEKLSNY
CCCCCCCCHHHHHHH		59.6524763107
376PhosphorylationVPSDEKLSNYAAEKE
CCCHHHHHHHHHHHH		38.5728889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TIP1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TIP1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TIP1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MAL3_SCHPOmal3physical
15177031
MAL3_SCHPOmal3physical
15062095
TEA2_SCHPOtea2physical
15177031
STU1_SCHPOpeg1physical
16951255
MAL3_SCHPOmal3physical
16951255
TIP1_SCHPOtip1physical
16951255
DSK2_SCHPOdph1physical
19808886
CDC16_SCHPOcdc16genetic
20498706
MAD2_SCHPOmad2genetic
20498706
TEA2_SCHPOtea2physical
20498706
PP2B_SCHPOppb1physical
21336311
SPN1_SCHPOspn1genetic
18818364
RDP1_SCHPOrdp1genetic
18818364
SPC34_SCHPOspc34genetic
18818364
SRB11_SCHPOsrb11genetic
18818364
ASH2_SCHPOash2genetic
18818364
PNPP_SCHPOpho2genetic
18818364
RSC4_SCHPOrsc4genetic
18818364
SWD2_SCHPOswd2genetic
18818364
SGF29_SCHPOsgf29genetic
18818364
ASK1_SCHPOask1genetic
18818364
NGG1_SCHPOngg1genetic
18818364
YB3C_SCHPOcay1genetic
18818364
MUB1_SCHPOSPBC31F10.10cgenetic
18818364
HIR1_SCHPOhip1genetic
18818364
FBH1_SCHPOfbh1genetic
18818364
SWD3_SCHPOswd3genetic
18818364
ELP1_SCHPOelp1genetic
18818364
ELP6_SCHPOelp6genetic
18818364
CLR4_SCHPOclr4genetic
18818364
RSC1_SCHPOrsc1genetic
18818364
HPC2_SCHPOhip4genetic
18818364
AIR1_SCHPOair1genetic
18818364
ELP4_SCHPOelp4genetic
18818364
RIK1_SCHPOrik1genetic
18818364
RPA12_SCHPOrpa12genetic
18818364
URK1_SCHPOSPCC162.11cgenetic
18818364
CAF1_SCHPOcaf1genetic
18818364
2AD1_SCHPOpar1genetic
18818364
SET1_SCHPOset1genetic
18818364
SPP1_SCHPOspf1genetic
18818364
RAF1_SCHPOraf1genetic
18818364
ASF1_SCHPOcia1genetic
18818364
YFE6_SCHPOgmh5genetic
18818364
NSE6_SCHPOnse6genetic
22681890
PUB1_SCHPOpub1genetic
22681890
HRP3_SCHPOhrp3genetic
22681890
VTS1_SCHPOSPBC13E7.03cgenetic
22681890
DPH3_SCHPOdph3genetic
22681890
BDC1_SCHPObdc1genetic
22681890
PAC2_SCHPOpac2genetic
22681890
YNU4_SCHPOSPBC28E12.04genetic
22681890
ELP6_SCHPOelp6genetic
22681890
RNC1_SCHPOrnc1genetic
22681890
SWD3_SCHPOswd3genetic
22681890
YAC5_SCHPOcph1genetic
22681890
GOS1_SCHPOgos1genetic
22681890
VIP1_SCHPOasp1genetic
22681890
RPA12_SCHPOrpa12genetic
22681890
NEM1_SCHPOnem1genetic
22681890
SPP1_SCHPOspf1genetic
22681890
MBO1_SCHPOmto1genetic
22681890
YGWH_SCHPOgmh4genetic
22681890
ZRG17_SCHPOzrg17genetic
22681890
RSC4_SCHPOrsc4genetic
22681890
TEA2_SCHPOtea2genetic
22681890
SGF73_SCHPOsgf73genetic
22681890
ASH2_SCHPOash2genetic
22681890
SSN3_SCHPOsrb10genetic
22681890
MUG20_SCHPOmug20genetic
22681890
DSK1_SCHPOdsk1genetic
22681890
ATG17_SCHPOatg17genetic
22681890
YOW5_SCHPOSPBC1861.05genetic
22681890
SET1_SCHPOset1genetic
22681890
CTK3_SCHPOlsg1genetic
22681890
ASK1_SCHPOask1genetic
22681890
YB33_SCHPOebs1genetic
22681890
SUM2_SCHPOsum2genetic
22681890
DAD2_SCHPOdad2genetic
22681890
MID1_SCHPOmid1genetic
22681890
PVH1_SCHPOSPBC17A3.06genetic
22681890
YJC7_SCHPOSPCC736.07cgenetic
22681890
YFE6_SCHPOgmh5genetic
22681890
YOX1_SCHPOyox1genetic
22681890
TCG1_SCHPOtcg1genetic
22681890
MAD1_SCHPOmad1genetic
22681890
TEA2_SCHPOtea2physical
23695164
TEA1_SCHPOtea1physical
23695164
MAL3_SCHPOmal3genetic
23613905
TIP1_SCHPOtip1physical
26771498
MUG79_SCHPOspo7physical
26771498
TEA2_SCHPOtea2physical
26771498
TEA1_SCHPOtea1physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TIP1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82; SER-84; SER-289;SER-294; SER-305 AND THR-367, AND MASS SPECTROMETRY.

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