| UniProt ID | ASK1_SCHPO | |
|---|---|---|
| UniProt AC | Q9P6S5 | |
| Protein Name | DASH complex subunit ask1 | |
| Gene Name | ask1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 307 | |
| Subcellular Localization | Nucleus. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Associates with the mitotic spindle and the kinetochore. Kinetochore association occurs only during mitosis. | |
| Protein Description | Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. Plays a role in meiosis.. | |
| Protein Sequence | MNNLEQLERLEQSITLALYEIDANFSKCHRTVTTKILPIVEKYAKNCNTIWDSSKFWKQFFEASANVSLSGVEEPVPVESNPSDQDVMSNSTEADLQLHTKNEHLEKRHSFVGKSDFPDAAVQGDNTKNEDFVQSTPKKMDVSLEDISLDDAALTPIPARMQTPLRKPENNPHTGRSALLHRVLDTNWQVQVTPREPKNLQSQEVMDIDSSPFVSPSPISMKMDMPSLNDRNSSHALSLFAEFEHESYDSINPSGMSPPKTIQFSPHTMGVGSSQQANERSLSLQRKLETLNDSNDSFVKEEDSWEL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 110 | Phosphorylation | EHLEKRHSFVGKSDF HHHHHHHCCCCCCCC | 26.17 | 24763107 | |
| 135 | Phosphorylation | KNEDFVQSTPKKMDV CCHHHHHCCCCEECC | 41.18 | 29996109 | |
| 136 | Phosphorylation | NEDFVQSTPKKMDVS CHHHHHCCCCEECCC | 23.26 | 28889911 | |
| 143 | Phosphorylation | TPKKMDVSLEDISLD CCCEECCCHHHCCCC | 23.06 | 25720772 | |
| 148 | Phosphorylation | DVSLEDISLDDAALT CCCHHHCCCCCHHCC | 37.76 | 25720772 | |
| 155 | Phosphorylation | SLDDAALTPIPARMQ CCCCHHCCCCCCCCC | 17.91 | 25720772 | |
| 163 | Phosphorylation | PIPARMQTPLRKPEN CCCCCCCCCCCCCCC | 18.23 | 29996109 | |
| 186 | Phosphorylation | LLHRVLDTNWQVQVT HHHHHHCCCCEEEEC | 33.91 | 29996109 | |
| 193 | Phosphorylation | TNWQVQVTPREPKNL CCCEEEECCCCCCCC | 10.27 | 29996109 | |
| 265 | Phosphorylation | PPKTIQFSPHTMGVG CCCEEEECCCCCCCC | 10.21 | 29996109 | |
| 268 | Phosphorylation | TIQFSPHTMGVGSSQ EEEECCCCCCCCCHH | 21.00 | 29996109 | |
| 294 | Phosphorylation | KLETLNDSNDSFVKE HHHHHCCCCCCCCCH | 41.27 | 21712547 | |
| 297 | Phosphorylation | TLNDSNDSFVKEEDS HHCCCCCCCCCHHHC | 35.87 | 24763107 | |
| 304 | Phosphorylation | SFVKEEDSWEL---- CCCCHHHCCCC---- | 26.23 | 21712547 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ASK1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ASK1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ASK1_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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