ATC2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATC2_SCHPO
• UniProt AC: Q9HDW7
• Protein Name: Calcium-transporting ATPase 2
• Gene Name: pmc1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1292
• Subcellular Localization: Vacuole membrane ; Multi-pass membrane protein .
• Protein Description: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium..
• Protein Sequence: MPTYNDDDDSSRPPSVHSERNQKPSSSQFLGVPSSNYNQRENSSRSGSSTISREPSSSGTMYPMASRDSMKESYDKNKGTPPDYTSYVSHSDAEPEQASSKSSTSIEDLLHTEYDDAPFAFSIPLLQRLQDPKNTSLLHAIHGLKGLCKGLKVDPSTGISTHEPHYADKLQMSDILNDDSNPKLVVHLDRIRSQDNNPEAKVSHDSDRVKYYGKNVLPEHDSKGLIRLMLEAFKDKVLILLSIAAVVSLALGLYQTFGQPPTLDPITGKPEPRVEWVEGVAIMAAIVIVVTVGGVNDWQKELQFKKLNAKVSNFDVQVLRDGAVHSTSVFDLVVGDVLFVEAGDVVPVDGVLIESNNLVLDESAMTGETDNIKKVDANTAIERTSPDVEYRKNADPYLISGTTILEGNGKLLVTAVGVNSFNGRTTMAMRTEGQATPLQLRLSRVADAIAKLGGAASALLFIVLLIEFLVRLKSNDSSSKNKGQEFLQILIVSVTLLVVAVPEGLPLAVTLALAFATNRMQKDNNLVRHLQACETMGTATNICSDKTGTLTQNRMTVVAGGFGTDVLFFDHNDETPTNVDQGSDSSKFEDAGASAFAFKRLSPELRDLTLYSIAVNSTCRQLFEDNSDTPRFIGSKTETALLDMSVKELGLTNVDSMRSSVDIKQFFSFSSDRKASGAIFEYKDKYYFVVKGMPERVLQQSTSVITNGSLDEVEDMHSHADYFKEMITGYAKRSLRTLGLCYRVFDSWPPKDIPTNDEDSSNPLKWEDAFTDMTFLGFFGIMDPIRPDVPLAVKVCQGAGVTVRMVTGDNIVTAKAIASQCGIYTEDGISMEGPEFRSLSDEKRLEILPKLDVLARSSPLDKQLLIEGLQKLGNVVAVTGDGTNDAPALKKANVGFSMGKSGTEVAKEASDIILMDDNFSSIVKAIAWGRTVNDAVKKFLQFQITVNITAVFLTIISAVASTDQSSVLTAVQLLWVNLIMDTLAALALATDPPTPEVLKRKPEKPGASLFTFDMWKMIICQSMYQLAVTLVLHFAGNSIFHYPSNTADMNTIVFNTFVWLQLFNEINNRRLDNKLNIFERINHNFLFIAIFVIVAGIQVIIVFFGGAAFSVKRIDGKGWAISIVFGVISIPLGALIRCVPNNFLRKVLPVKTIDTVFSWILNPRFRSKRRSTDHDVESLSLIPYEPTSPNEVIDSIRHSLGFVQRIRGGRIRHLLNNSKFDKQMEALPERLRPRVKQRFMKIRSPSVSSATSVALMIPISTLVSEASGRLGGHDIWISHNRQALDKKSSNVH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPTYNDDDDSS ----CCCCCCCCCCC	27.59	29996109
10	Phosphorylation	TYNDDDDSSRPPSVH CCCCCCCCCCCCCCC	34.93	21712547
11	Phosphorylation	YNDDDDSSRPPSVHS CCCCCCCCCCCCCCC	56.66	21712547
15	Phosphorylation	DDSSRPPSVHSERNQ CCCCCCCCCCCCCCC	34.83	28889911
18	Phosphorylation	SRPPSVHSERNQKPS CCCCCCCCCCCCCCC	35.78	21712547
85	Phosphorylation	KGTPPDYTSYVSHSD CCCCCCHHHCCCCCC	22.44	29996109
87	Phosphorylation	TPPDYTSYVSHSDAE CCCCHHHCCCCCCCC	9.73	25720772
91	Phosphorylation	YTSYVSHSDAEPEQA HHHCCCCCCCCHHHH	30.89	28889911
102	Phosphorylation	PEQASSKSSTSIEDL HHHHCCCCCCCHHHH	40.57	21712547
103	Phosphorylation	EQASSKSSTSIEDLL HHHCCCCCCCHHHHH	29.88	21712547
105	Phosphorylation	ASSKSSTSIEDLLHT HCCCCCCCHHHHHCC	26.40	21712547
193	Phosphorylation	VHLDRIRSQDNNPEA EEHHHHHCCCCCCCC	39.24	24763107
1171	Phosphorylation	RFRSKRRSTDHDVES HHHCCCCCCCCCCCC	42.07	29996109
1178	Phosphorylation	STDHDVESLSLIPYE CCCCCCCCCCCCCCC	24.09	29996109
1180	Phosphorylation	DHDVESLSLIPYEPT CCCCCCCCCCCCCCC	33.27	29996109
1244	Phosphorylation	QRFMKIRSPSVSSAT HHHHHHCCCCCCCCH	25.62	29996109
1251	Phosphorylation	SPSVSSATSVALMIP CCCCCCCHHHEEEEE	26.19	29996109
1252	Phosphorylation	PSVSSATSVALMIPI CCCCCCHHHEEEEEH	12.71	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATC2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATC2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATC2_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of ATC2_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.