MPD2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPD2_SCHPO
• UniProt AC: O36025
• Protein Name: GYF domain-containing protein mpd2
• Gene Name: mpd2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 992
• Subcellular Localization: Cytoplasm .
• Protein Description: Has a role in mRNA export from the nucleus..
• Protein Sequence: MNSEASVFSNMDWSQLAHSLHKKANNSSSSTTGAFPQLTSFTKPTATNGVDSPTSSHIDPSVSAKLDSQRKLSLKSGNMWDSLNAPSELTSKNPTVSSTTSSANPAIVSNGGSPFYKNPVVANNPSSTFDMSTNLFNSKNANTSFTNAFSNEGISPGFLRDCFPSSNSITTGTASPKLGSPFNHINRPVLDRSPSSFSQSRSAVSGNMNPGVGTLQQPQRAGSDTFPDLNTSSSNQPGGEPNVASANTHSLEILSSSAYHPSGSSNGISAGLTQSVASPVGQVDNLADFSQSPLRRGPSRFPTNSNVPVGNSMSIRDTDSPLNILVDKAKAKASIKENASQPVAPSASQREHSAVNSPAAAMSPSTAMFSSEAFPQHLASLIPPALLHWLYKDPQNNVQGPFTGVDMHQWYRAGYFPLGLPIKRLEEEEYYSLAFFIRQVGNQLEPFLVPLSPVTVQNASWNAQGTDLPLSNYLPESSEQNRGGNKHLELYPSTAEVSNVRNDESKANSLSEISYNQQSECRSSELNVNEDSANQKEESALGTSDNSDMYEKENTPIHHNESLNQLSKDLGSISLSEETKQEKPSKLKETVESKRLSTGVQKQSPAASKEIPVTSGSQTTAPKPSPWKSLPPKHLPSLDETISREMSIASSEALPQVEKSNSDQPPVAIPSTSKTGSPWAKVSDVSTSMAQEIQRMEKQNENLKSKVASNPVSQTSTNAKASTPALASGSIWGSPSVINAWANKPAALKSPLIKKNIQQAELAQNKQQSSVTTASPRSNALNANTPKAAAPSSNVTMKNVTSILETSTFEGEDTWSVVGPGGKIVNQQSPSAQQTTRSPSKVSATLNAGNSQASTSSKLQQVVSMSGHSPDFLAWCKISLKGLNEGVNYEEFLDMLLSLPAENNVETFEIISDSIYANSTIMDGRRFASEFTRRRIADLTGKDGQQSNNKSQSELGNSSGAWSQVVRNKPKQGTEWNSAFKVVTSKKNKKRV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	HKKANNSSSSTTGAF HHHHCCCCCCCCCCC	30.36	27738172
29	Phosphorylation	KKANNSSSSTTGAFP HHHCCCCCCCCCCCC	31.37	21712547
30	Phosphorylation	KANNSSSSTTGAFPQ HHCCCCCCCCCCCCC	31.75	27738172
31	Phosphorylation	ANNSSSSTTGAFPQL HCCCCCCCCCCCCCC	31.06	27738172
39	Phosphorylation	TGAFPQLTSFTKPTA CCCCCCCCCCCCCCC	19.29	24763107
40	Phosphorylation	GAFPQLTSFTKPTAT CCCCCCCCCCCCCCC	39.24	24763107
42	Phosphorylation	FPQLTSFTKPTATNG CCCCCCCCCCCCCCC	35.56	29996109
45	Phosphorylation	LTSFTKPTATNGVDS CCCCCCCCCCCCCCC	47.90	27738172
47	Phosphorylation	SFTKPTATNGVDSPT CCCCCCCCCCCCCCC	34.68	21712547
52	Phosphorylation	TATNGVDSPTSSHID CCCCCCCCCCCCCCC	27.89	24763107
55	Phosphorylation	NGVDSPTSSHIDPSV CCCCCCCCCCCCHHH	24.25	21712547
56	Phosphorylation	GVDSPTSSHIDPSVS CCCCCCCCCCCHHHH	27.26	21712547
63	Phosphorylation	SHIDPSVSAKLDSQR CCCCHHHHHHCCCCC	24.83	27738172
68	Phosphorylation	SVSAKLDSQRKLSLK HHHHHCCCCCCEECC	42.17	24763107
73	Phosphorylation	LDSQRKLSLKSGNMW CCCCCCEECCCCCCH	36.46	21712547
95	Phosphorylation	ELTSKNPTVSSTTSS HHHCCCCCCCCCCCC	42.27	27738172
100	Phosphorylation	NPTVSSTTSSANPAI CCCCCCCCCCCCCEE	23.72	28889911
109	Phosphorylation	SANPAIVSNGGSPFY CCCCEEECCCCCCCC	24.52	21712547
113	Phosphorylation	AIVSNGGSPFYKNPV EEECCCCCCCCCCCC	17.15	28889911
126	Phosphorylation	PVVANNPSSTFDMST CCCCCCCCCCCCCCC	44.10	24763107
127	Phosphorylation	VVANNPSSTFDMSTN CCCCCCCCCCCCCCC	34.06	25720772
128	Phosphorylation	VANNPSSTFDMSTNL CCCCCCCCCCCCCCC	28.17	25720772
143	Phosphorylation	FNSKNANTSFTNAFS CCCCCCCCCCCHHCC	23.86	29996109
144	Phosphorylation	NSKNANTSFTNAFSN CCCCCCCCCCHHCCC	29.85	29996109
146	Phosphorylation	KNANTSFTNAFSNEG CCCCCCCCHHCCCCC	25.96	25720772
150	Phosphorylation	TSFTNAFSNEGISPG CCCCHHCCCCCCCCC	31.40	29996109
155	Phosphorylation	AFSNEGISPGFLRDC HCCCCCCCCCCHHHC	29.81	29996109
165	Phosphorylation	FLRDCFPSSNSITTG CHHHCCCCCCCCCCC	23.15	25720772
166	Phosphorylation	LRDCFPSSNSITTGT HHHCCCCCCCCCCCC	34.53	29996109
168	Phosphorylation	DCFPSSNSITTGTAS HCCCCCCCCCCCCCC	24.22	25720772
170	Phosphorylation	FPSSNSITTGTASPK CCCCCCCCCCCCCCC	20.99	29996109
171	Phosphorylation	PSSNSITTGTASPKL CCCCCCCCCCCCCCC	30.75	29996109
173	Phosphorylation	SNSITTGTASPKLGS CCCCCCCCCCCCCCC	23.13	25720772
175	Phosphorylation	SITTGTASPKLGSPF CCCCCCCCCCCCCCC	23.54	28889911
180	Phosphorylation	TASPKLGSPFNHINR CCCCCCCCCCCCCCC	36.43	28889911
193	Phosphorylation	NRPVLDRSPSSFSQS CCCCCCCCCCCCCCC	28.88	25720772
195	Phosphorylation	PVLDRSPSSFSQSRS CCCCCCCCCCCCCCH	45.31	29996109
196	Phosphorylation	VLDRSPSSFSQSRSA CCCCCCCCCCCCCHH	32.09	28889911
198	Phosphorylation	DRSPSSFSQSRSAVS CCCCCCCCCCCHHHC	29.24	29996109
200	Phosphorylation	SPSSFSQSRSAVSGN CCCCCCCCCHHHCCC	27.31	29996109
314	Phosphorylation	VPVGNSMSIRDTDSP CCCCCCCCCCCCCCC	17.81	27738172
318	Phosphorylation	NSMSIRDTDSPLNIL CCCCCCCCCCCHHHH	28.64	28889911
320	Phosphorylation	MSIRDTDSPLNILVD CCCCCCCCCHHHHHH	33.12	28889911
334	Phosphorylation	DKAKAKASIKENASQ HHHHHHHHHHHCCCC	33.22	25720772
346	Phosphorylation	ASQPVAPSASQREHS CCCCCCCCHHHHHHH	30.71	29996109
348	Phosphorylation	QPVAPSASQREHSAV CCCCCCHHHHHHHHC	33.82	29996109
493	Phosphorylation	KHLELYPSTAEVSNV CCCEECCCCCHHHCC	27.05	21712547
494	Phosphorylation	HLELYPSTAEVSNVR CCEECCCCCHHHCCC	23.49	21712547
498	Phosphorylation	YPSTAEVSNVRNDES CCCCCHHHCCCCCHH	22.55	24763107
505	Phosphorylation	SNVRNDESKANSLSE HCCCCCHHHCCCCCC	39.67	25720772
509	Phosphorylation	NDESKANSLSEISYN CCHHHCCCCCCCCCC	37.83	28889911
511	Phosphorylation	ESKANSLSEISYNQQ HHHCCCCCCCCCCCC	32.48	29996109
514	Phosphorylation	ANSLSEISYNQQSEC CCCCCCCCCCCCHHH	17.61	25720772
515	Phosphorylation	NSLSEISYNQQSECR CCCCCCCCCCCHHHH	23.74	25720772
523	Phosphorylation	NQQSECRSSELNVNE CCCHHHHHCCCCCCC	39.56	29996109
524	Phosphorylation	QQSECRSSELNVNED CCHHHHHCCCCCCCC	27.10	29996109
539	Phosphorylation	SANQKEESALGTSDN CCHHHHHHHHCCCCC	29.86	24763107
543	Phosphorylation	KEESALGTSDNSDMY HHHHHHCCCCCHHHC	33.48	21712547
544	Phosphorylation	EESALGTSDNSDMYE HHHHHCCCCCHHHCC	32.75	28889911
547	Phosphorylation	ALGTSDNSDMYEKEN HHCCCCCHHHCCCCC	28.84	24763107
550	Phosphorylation	TSDNSDMYEKENTPI CCCCHHHCCCCCCCC	28.92	29996109
555	Phosphorylation	DMYEKENTPIHHNES HHCCCCCCCCCCCHH	25.39	28889911
562	Phosphorylation	TPIHHNESLNQLSKD CCCCCCHHHHHHHHH	37.63	28889911
567	Phosphorylation	NESLNQLSKDLGSIS CHHHHHHHHHHCCCC	17.85	21712547
572	Phosphorylation	QLSKDLGSISLSEET HHHHHHCCCCCCHHH	19.12	25720772
574	Phosphorylation	SKDLGSISLSEETKQ HHHHCCCCCCHHHHC	27.78	24763107
576	Phosphorylation	DLGSISLSEETKQEK HHCCCCCCHHHHCCC	26.96	25720772
579	Phosphorylation	SISLSEETKQEKPSK CCCCCHHHHCCCCCH	33.69	25720772
597	Phosphorylation	TVESKRLSTGVQKQS HHHHHHHCCCCCCCC	27.44	21712547
598	Phosphorylation	VESKRLSTGVQKQSP HHHHHHCCCCCCCCC	46.06	28889911
604	Phosphorylation	STGVQKQSPAASKEI CCCCCCCCCCCCCCC	24.44	28889911
608	Phosphorylation	QKQSPAASKEIPVTS CCCCCCCCCCCCCCC	32.69	24763107
614	Phosphorylation	ASKEIPVTSGSQTTA CCCCCCCCCCCCCCC	23.24	29996109
615	Phosphorylation	SKEIPVTSGSQTTAP CCCCCCCCCCCCCCC	36.36	29996109
617	Phosphorylation	EIPVTSGSQTTAPKP CCCCCCCCCCCCCCC	24.91	21712547
619	Phosphorylation	PVTSGSQTTAPKPSP CCCCCCCCCCCCCCC	26.99	29996109
620	Phosphorylation	VTSGSQTTAPKPSPW CCCCCCCCCCCCCCH	33.07	29996109
625	Phosphorylation	QTTAPKPSPWKSLPP CCCCCCCCCHHCCCH	49.90	28889911
637	Phosphorylation	LPPKHLPSLDETISR CCHHHCCCHHHHHHH	55.61	28889911
647	Phosphorylation	ETISREMSIASSEAL HHHHHHHHHHCCCCC	15.39	25720772
650	Phosphorylation	SREMSIASSEALPQV HHHHHHHCCCCCCHH	27.35	28889911
662	Phosphorylation	PQVEKSNSDQPPVAI CHHHCCCCCCCCCCC	44.72	25720772
671	Phosphorylation	QPPVAIPSTSKTGSP CCCCCCCCCCCCCCC	38.92	24763107
672	Phosphorylation	PPVAIPSTSKTGSPW CCCCCCCCCCCCCCC	28.96	29996109
673	Phosphorylation	PVAIPSTSKTGSPWA CCCCCCCCCCCCCCC	32.34	28889911
675	Phosphorylation	AIPSTSKTGSPWAKV CCCCCCCCCCCCCCH	42.53	28889911
677	Phosphorylation	PSTSKTGSPWAKVSD CCCCCCCCCCCCHHH	23.62	28889911
688	Phosphorylation	KVSDVSTSMAQEIQR CHHHHCHHHHHHHHH	12.48	29996109
722	Phosphorylation	TSTNAKASTPALASG CCCCCCCCCCCHHCC	33.93	29996109
723	Phosphorylation	STNAKASTPALASGS CCCCCCCCCCHHCCC	19.90	24763107
728	Phosphorylation	ASTPALASGSIWGSP CCCCCHHCCCCCCCH	33.64	21712547
730	Phosphorylation	TPALASGSIWGSPSV CCCHHCCCCCCCHHH	16.81	24763107
734	Phosphorylation	ASGSIWGSPSVINAW HCCCCCCCHHHHHHH	10.06	21712547
736	Phosphorylation	GSIWGSPSVINAWAN CCCCCCHHHHHHHHC	37.01	21712547
750	Phosphorylation	NKPAALKSPLIKKNI CCCHHHCCHHHHHHH	26.28	24763107
772	Phosphorylation	NKQQSSVTTASPRSN HHCCCCCCCCCHHHH	20.70	29996109
773	Phosphorylation	KQQSSVTTASPRSNA HCCCCCCCCCHHHHC	24.00	29996109
775	Phosphorylation	QSSVTTASPRSNALN CCCCCCCCHHHHCCC	20.82	28889911
778	Phosphorylation	VTTASPRSNALNANT CCCCCHHHHCCCCCC	29.82	21712547
785	Phosphorylation	SNALNANTPKAAAPS HHCCCCCCCCCCCCC	24.61	28889911
829	Phosphorylation	GKIVNQQSPSAQQTT CEECCCCCCCCCCCC	15.85	28889911
831	Phosphorylation	IVNQQSPSAQQTTRS ECCCCCCCCCCCCCC	43.91	21712547
835	Phosphorylation	QSPSAQQTTRSPSKV CCCCCCCCCCCCCHH	16.46	29996109
836	Phosphorylation	SPSAQQTTRSPSKVS CCCCCCCCCCCCHHE	25.47	25720772
838	Phosphorylation	SAQQTTRSPSKVSAT CCCCCCCCCCHHEEE	31.28	28889911
840	Phosphorylation	QQTTRSPSKVSATLN CCCCCCCCHHEEEEE	47.11	28889911
843	Phosphorylation	TRSPSKVSATLNAGN CCCCCHHEEEEECCC	21.19	29996109
845	Phosphorylation	SPSKVSATLNAGNSQ CCCHHEEEEECCCCC	17.03	29996109
951	Phosphorylation	GQQSNNKSQSELGNS CCCCCCCCHHHHCCC	40.85	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPD2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MPD2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPD2_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of MPD2_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-175; THR-318; SER-320;SER-509; SER-604; SER-637; SER-775; SER-829; SER-838 AND SER-840, ANDMASS SPECTROMETRY.
PubMed: 18257517