SET3_SCHPO - dbPTM
SET3_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SET3_SCHPO
UniProt AC Q10362
Protein Name SET domain-containing protein 3
Gene Name set3
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 859
Subcellular Localization Nucleus .
Protein Description Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Required for both gene activation and repression. Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis. Required for the transcriptional activation of genes with high activity (By similarity)..
Protein Sequence MWKIRCVCPFEDDDGFTIQCESCEVWQHAVCVNIDANNVPEKYFCEQCQPRPIDADKAHKIQLARLQREEEQSRILSRSRSSNNKRRTSFGKNGASPTHSASPRQGNNTGANGALFSQSTNSSNSGSYRNSVTGATLPNAHAPHSQNRRRRSNHLNNPPEAPITEASNEYVYSFHLEYVPLESNTFSASALEYSKNLDLKNLDESEVLMDGCQVVPISSSKFCCSRFGLVSTCEIPPNTPIMEVKGRVCTQNEYKSDPKNQYNILGAPKPHVFFDSNSQLVVDSRVAGSKARFARKGCQSNSVVSSVYMNGSNSVPRFILYSTTHIAPETEIIGDWTLDISHPFRQFAPGMSRPSFNMEELELLSEVLSTFLSFNECASQDKKNCVFSRVTKYIKAARRASTANRVSVAKDRLSLTPSSTPSTPSPAESLPQPSNPTSVYAKSLKEFWLDKYRLSILQKWPAVKSLPTESVGIDVVMEPKLQPSVKEKKPTKDLQSPLPSVEEDSSNRDKKTDIADLHTDSKVGIADVLSPISPDAALQSDGPLKKAKEPEESSITPTTPPSFNVGESLSRRSASPLQHPRTSPDMLDKTSPCKRGLGTITTVHKKHGSVDHLPSVKRRRSIANDFHGKPDYNKRSLSIERKPEAFKTKGDRPHKVHPSFHRNSDSKLKLEPSSKEKSGSMFFNTLRTVKDKSHVHDTQRSSDVNFSRQNGTRSHSPSVSPVGFSFDKSPVTTPPLPTAPAPVITSRHALVNNQFPTNNPNILDHKANNGDDISNALNTSRSENKPNSNLVQGSVVKPSNTSASALPTSAPKKLSLSEYRQRRQQNILHQQSKDNQAHGDTARPHTVPAATVSNPSFTR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
89PhosphorylationSNNKRRTSFGKNGAS
CCCCCCCCCCCCCCC		30.1425720772
96PhosphorylationSFGKNGASPTHSASP
CCCCCCCCCCCCCCC		31.5625720772
496PhosphorylationKPTKDLQSPLPSVEE
CCCCCCCCCCCCCCC		35.3828889911
500PhosphorylationDLQSPLPSVEEDSSN
CCCCCCCCCCCCCCC		50.2529996109
530PhosphorylationVGIADVLSPISPDAA
CCHHHHCCCCCCCHH		21.7521712547
533PhosphorylationADVLSPISPDAALQS
HHHCCCCCCCHHHCC		21.8028889911
540PhosphorylationSPDAALQSDGPLKKA
CCCHHHCCCCCCCCC		45.4425720772
553PhosphorylationKAKEPEESSITPTTP
CCCCCCCCCCCCCCC		25.9425720772
556PhosphorylationEPEESSITPTTPPSF
CCCCCCCCCCCCCCC		19.2729996109
558PhosphorylationEESSITPTTPPSFNV
CCCCCCCCCCCCCCC		43.2029996109
559PhosphorylationESSITPTTPPSFNVG
CCCCCCCCCCCCCCC		34.1129996109
573PhosphorylationGESLSRRSASPLQHP
CCCCCCCCCCCCCCC		31.8029996109
575PhosphorylationSLSRRSASPLQHPRT
CCCCCCCCCCCCCCC		27.6528889911
582PhosphorylationSPLQHPRTSPDMLDK
CCCCCCCCCHHHHCC		49.4125720772
583PhosphorylationPLQHPRTSPDMLDKT
CCCCCCCCHHHHCCC		21.8529996109
621PhosphorylationPSVKRRRSIANDFHG
CCHHHHHHHHHCCCC		25.0029996109
714PhosphorylationSRQNGTRSHSPSVSP
CCCCCCCCCCCCCCC		28.3128889911
716PhosphorylationQNGTRSHSPSVSPVG
CCCCCCCCCCCCCCC		21.8128889911
718PhosphorylationGTRSHSPSVSPVGFS
CCCCCCCCCCCCCEE		37.9428889911
720PhosphorylationRSHSPSVSPVGFSFD
CCCCCCCCCCCEECC		20.4325720772
725PhosphorylationSVSPVGFSFDKSPVT
CCCCCCEECCCCCCC		26.9725720772
729PhosphorylationVGFSFDKSPVTTPPL
CCEECCCCCCCCCCC		26.8425720772
733PhosphorylationFDKSPVTTPPLPTAP
CCCCCCCCCCCCCCC		24.1229996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SET3_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SET3_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SET3_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ROK1_SCHPOrok1genetic
18818364
PNK1_SCHPOpnk1genetic
18818364
ARP42_SCHPOarp42genetic
18818364
IWR1_SCHPOiwr1genetic
18818364
FFT3_SCHPOfft3genetic
18818364
MSC1_SCHPOmsc1genetic
18818364
SSU72_SCHPOssu72genetic
18818364
SNT2_SCHPOsnt2genetic
18818364
RYH1_SCHPOryh1genetic
18818364
YK82_SCHPObdf2genetic
18818364
ARP8_SCHPOarp8genetic
18818364
YIQ4_SCHPOSPAC824.04genetic
18818364
SPC34_SCHPOspc34genetic
18818364
REB1_SCHPOreb1genetic
18818364
H2AZ_SCHPOpht1genetic
18818364
ASH2_SCHPOash2genetic
18818364
PAB2_SCHPOpab2genetic
18818364
YBPD_SCHPOSPBC16H5.13genetic
18818364
ING2_SCHPOpng2genetic
18818364
ELP5_SCHPOelp5genetic
18818364
BDC1_SCHPObdc1genetic
18818364
COPE_SCHPOsec28genetic
18818364
ASK1_SCHPOask1genetic
18818364
VPS71_SCHPOvps71genetic
18818364
PDP1_SCHPOpdp1genetic
18818364
YB3C_SCHPOcay1genetic
18818364
YO48_SCHPOSPBC36B7.08cgenetic
18818364
RSC1_SCHPOrsc1genetic
18818364
DSK1_SCHPOdsk1genetic
18818364
POB3_SCHPOpob3genetic
18818364
CLR3_SCHPOclr3genetic
18818364
HPC2_SCHPOhip4genetic
18818364
AIR1_SCHPOair1genetic
18818364
VPS72_SCHPOswc2genetic
18818364
ELP4_SCHPOelp4genetic
18818364
PEF1_SCHPOpef1genetic
18818364
CAF1_SCHPOcaf1genetic
18818364
YQ9A_SCHPOSPCC18.10genetic
18818364
SDC1_SCHPOsdc1genetic
18818364
2AD1_SCHPOpar1genetic
18818364
AAKB_SCHPOamk2genetic
18818364
SET1_SCHPOset1genetic
18818364
CCR4_SCHPOccr4genetic
18818364
ARP6_SCHPOarp6genetic
18818364
SWC5_SCHPOswc5genetic
18818364
RNC1_SCHPOrnc1genetic
18818364
SGF29_SCHPOsgf29genetic
18818364
NGG1_SCHPOngg1genetic
18818364
FBH1_SCHPOfbh1genetic
18818364
YGWG_SCHPOSPBC8D2.16cgenetic
18818364
HEL2_SCHPOSPCC1223.01genetic
18818364
URK1_SCHPOSPCC162.11cgenetic
18818364
FLP1_SCHPOclp1genetic
22347452
CTK1_SCHPOlsk1genetic
22347452
HIF2_SCHPOhif2physical
22347452
PHD1_SCHPOhos2physical
22559741
MPH1L_SCHPOmph1genetic
22681890
RYH1_SCHPOryh1genetic
22681890
SFT1_SCHPOsft1genetic
22681890
SDS23_SCHPOsds23genetic
22681890
VTS1_SCHPOSPBC13E7.03cgenetic
22681890
ERI1_SCHPOeri1genetic
22681890
BDC1_SCHPObdc1genetic
22681890
6PGL_SCHPOSPCC16C4.10genetic
22681890
ARP6_SCHPOarp6genetic
22681890
RNC1_SCHPOrnc1genetic
22681890
SWD3_SCHPOswd3genetic
22681890
DBR1_SCHPOdbr1genetic
22681890
YIW4_SCHPOSPAC694.04cgenetic
22681890
DEP1_SCHPOdep1genetic
22681890
VIP1_SCHPOasp1genetic
22681890
ARP8_SCHPOarp8genetic
22681890
YK82_SCHPObdf2genetic
22681890
CCQ1_SCHPOccq1genetic
22681890
YIQ4_SCHPOSPAC824.04genetic
22681890
DAD1_SCHPOdad1genetic
22681890
GIT3_SCHPOgit3genetic
22681890
NCPR_SCHPOccr1genetic
22681890
YAQD_SCHPOSPAC18G6.13genetic
22681890
PAB2_SCHPOpab2genetic
22681890
ARP42_SCHPOarp42genetic
22681890
SWC3_SCHPOswc3genetic
22681890
MSC1_SCHPOmsc1genetic
22681890
ASH2_SCHPOash2genetic
22681890
YF19_SCHPOatd1genetic
22681890
GPA2_SCHPOgpa2genetic
22681890
SSN3_SCHPOsrb10genetic
22681890
APQ12_SCHPOapq12genetic
22681890
ING2_SCHPOpng2genetic
22681890
SNT2_SCHPOsnt2genetic
22681890
MMS19_SCHPOmms19genetic
22681890
LIZ1_SCHPOliz1genetic
22681890
YO48_SCHPOSPBC36B7.08cgenetic
22681890
DSK1_SCHPOdsk1genetic
22681890
VPS72_SCHPOswc2genetic
22681890
ATP11_SCHPOatp11genetic
22681890
CLR3_SCHPOclr3genetic
22681890
YOW5_SCHPOSPBC1861.05genetic
22681890
YIU1_SCHPOsaf5genetic
22681890
ROK1_SCHPOrok1genetic
22681890
YBAC_SCHPOrud3genetic
22681890
ASK1_SCHPOask1genetic
22681890
YBPD_SCHPOSPBC16H5.13genetic
22681890
YQ9A_SCHPOSPCC18.10genetic
22681890
KTI12_SCHPOSPAC30.02cgenetic
22681890
FFT3_SCHPOfft3genetic
22681890
DAD2_SCHPOdad2genetic
22681890
WDR21_SCHPOwdr21genetic
22681890
YA99_SCHPOSPAC13G6.09genetic
22681890
H2AZ_SCHPOpht1genetic
22681890
IMA2_SCHPOimp1genetic
22681890
GLU2A_SCHPOgls2genetic
22681890
TSC1_SCHPOtsc1genetic
22681890
TCG1_SCHPOtcg1genetic
22681890
SGF29_SCHPOsgf29genetic
22681890
ADN1_SCHPOadn1genetic
26173815
GSK3_SCHPOgsk3genetic
26173815
AP3S_SCHPOaps3genetic
26173815
TSC2_SCHPOtsc2genetic
26173815
NCS1_SCHPOncs1genetic
26173815
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SET3_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-496; SER-533; SER-575;SER-714 AND SER-716, AND MASS SPECTROMETRY.

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