ING2_SCHPO - dbPTM
ING2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ING2_SCHPO
UniProt AC O74736
Protein Name Chromatin modification-related protein png2
Gene Name png2
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 305
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Component of the clr6 histone deacetylase complex I' responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Has a role in silencing of mating type genes..
Protein Sequence MGTSGIEIFAALNDFTDAIVSVPESVCGKFTSLKEIDAQVRDIRQNVIQEIGVVLKNEKNDELSGEERCERLQKTLKEILPYSDSKICLATDAMNNIKSCIDRLDAGFEYVELEIPQQLRLGYPDDRALMNYHSTVTPQTSERRRETRRHQNNQHSQQYSSQERSSSYNNFEDASSPQSSYHTPTKRRKNAVPRKSSSPPLSSTKHAPQSTERRPVRRSESRLKQTNGEPLVKHDTLDSSDISREGEQLYCYCQQVSYGQMIGCDNENCKREWFHLPCVGLVEPPKGIWYCKECEELAKSSESRQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
167PhosphorylationSSQERSSSYNNFEDA
HHHHHHHHCCCCCCC		32.8825720772
175PhosphorylationYNNFEDASSPQSSYH
CCCCCCCCCCCCCCC		55.6729996109
176PhosphorylationNNFEDASSPQSSYHT
CCCCCCCCCCCCCCC		28.7825720772
179PhosphorylationEDASSPQSSYHTPTK
CCCCCCCCCCCCCCH		35.9327738172
181PhosphorylationASSPQSSYHTPTKRR
CCCCCCCCCCCCHHC		18.2428889911
183PhosphorylationSPQSSYHTPTKRRKN
CCCCCCCCCCHHCCC		25.1528889911
196PhosphorylationKNAVPRKSSSPPLSS
CCCCCCCCCCCCCCC		37.0121712547
197PhosphorylationNAVPRKSSSPPLSST
CCCCCCCCCCCCCCC		50.3128889911
198PhosphorylationAVPRKSSSPPLSSTK
CCCCCCCCCCCCCCC		37.3128889911
202PhosphorylationKSSSPPLSSTKHAPQ
CCCCCCCCCCCCCCC		41.5621712547
204PhosphorylationSSPPLSSTKHAPQST
CCCCCCCCCCCCCCC		24.3921712547
240PhosphorylationKHDTLDSSDISREGE
CCCCCCHHHCCCCCC		38.3329996109
243PhosphorylationTLDSSDISREGEQLY
CCCHHHCCCCCCEEE		29.3029996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ING2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ING2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ING2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
H2AZ_SCHPOpht1genetic
18931302
PHD1_SCHPOhos2genetic
18931302
YBKD_SCHPOgmh6genetic
19547744
VDAC_SCHPOSPAC1635.01genetic
19547744
YFE9_SCHPOSPAC637.09genetic
19547744
YDA5_SCHPOSPAC1F12.05genetic
19547744
YOP2_SCHPOSPBC418.02genetic
19547744
NTO1_SCHPOnto1genetic
18818364
SWD2_SCHPOswd2genetic
18818364
YB3C_SCHPOcay1genetic
18818364
REC14_SCHPOrec14genetic
18818364
RSC1_SCHPOrsc1genetic
18818364
POB3_SCHPOpob3genetic
18818364
RAD14_SCHPOrhp14genetic
18818364
HIF2_SCHPOhif2genetic
18818364
PEF1_SCHPOpef1genetic
18818364
YQ9A_SCHPOSPCC18.10genetic
18818364
SDC1_SCHPOsdc1genetic
18818364
BMT5_SCHPOSPCC1919.13cgenetic
18818364
SET1_SCHPOset1genetic
18818364
JHD1_SCHPOepe1genetic
18818364
RNC1_SCHPOrnc1genetic
18818364
VPH2_SCHPOvph2genetic
18818364
AP3B_SCHPOapl6genetic
22681890
6PGL_SCHPOSPCC16C4.10genetic
22681890
LUB1_SCHPOlub1genetic
22681890
VAM7_SCHPOSPCC594.06cgenetic
22681890
YDRC_SCHPOpng3genetic
22681890
YAC5_SCHPOcph1genetic
22681890
DBR1_SCHPOdbr1genetic
22681890
YIW4_SCHPOSPAC694.04cgenetic
22681890
ARP8_SCHPOarp8genetic
22681890
YIQ4_SCHPOSPAC824.04genetic
22681890
GCN5_SCHPOgcn5genetic
22681890
RICTR_SCHPOste20genetic
22681890
YAQD_SCHPOSPAC18G6.13genetic
22681890
PAB2_SCHPOpab2genetic
22681890
MUG80_SCHPOmug80genetic
22681890
ARP42_SCHPOarp42genetic
22681890
UGGG_SCHPOgpt1genetic
22681890
PHD1_SCHPOhos2genetic
22681890
SET3_SCHPOset3genetic
22681890
AP3D_SCHPOapl5genetic
22681890
ASH2_SCHPOash2genetic
22681890
PFD3_SCHPOpac10genetic
22681890
ZFS1_SCHPOzfs1genetic
22681890
SCS7_SCHPOscs7genetic
22681890
ATG16_SCHPOatg16genetic
22681890
SNT2_SCHPOsnt2genetic
22681890
ATP5E_SCHPOatp15genetic
22681890
YIDH_SCHPOSPAC227.17cgenetic
22681890
FKBP4_SCHPOfkbp39genetic
22681890
YLP3_SCHPOred1genetic
22681890
ATP11_SCHPOatp11genetic
22681890
YBKD_SCHPOgmh6genetic
22681890
MST2_SCHPOmst2genetic
22681890
YIU1_SCHPOsaf5genetic
22681890
TOM70_SCHPOtom70genetic
22681890
YQ9A_SCHPOSPCC18.10genetic
22681890
FFT3_SCHPOfft3genetic
22681890
YA99_SCHPOSPAC13G6.09genetic
22681890
IWR1_SCHPOiwr1genetic
22681890
CGM2_SCHPOmcs2genetic
22681890
MID1_SCHPOmid1genetic
22681890
SHF1_SCHPOshf1genetic
22681890
SGF29_SCHPOsgf29genetic
22681890
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ING2_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-181; THR-183; SER-197AND SER-198, AND MASS SPECTROMETRY.

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