dbPTM

SHF1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SHF1_SCHPO
UniProt AC	Q9UUI2
Protein Name	Small histone ubiquitination factor 1
Gene Name	shf1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	165
Subcellular Localization	Nucleus . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body .
Protein Description	Component of the histone H2B ubiquitin ligase complex (HULC) which plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation..
Protein Sequence	MSSRRNDYHYDGNDHQYRSPLKSNVDQNSFYESSYRSRQSYHQRTKTPRSSYDSPSSSTNSKEHNSPYHYRVPSNNSTRASFGAASTDTNVELPKINLPDSSLSSKLQSCKSACENSSQSLLNVEQQYAQQVHFWEKIRTDIYREGLRSDAAVKSLNDFVNNVSF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
66	Phosphorylation	TNSKEHNSPYHYRVP CCCCCCCCCCEEECC	28889911
70	Phosphorylation	EHNSPYHYRVPSNNS CCCCCCEEECCCCCC	21712547
74	Phosphorylation	PYHYRVPSNNSTRAS CCEEECCCCCCCCCE	21712547
81	Phosphorylation	SNNSTRASFGAASTD CCCCCCCEECCCCCC	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SHF1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SHF1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SHF1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC2_SCHPO	rhp6	physical	17363370
BRL2_SCHPO	brl2	physical	17363370
BRL1_SCHPO	brl1	physical	17363370

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SHF1_SCHPO

Related Literatures of Post-Translational Modification