dbPTM

BRL1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BRL1_SCHPO
UniProt AC	Q1MTQ0
Protein Name	E3 ubiquitin-protein ligase brl1
Gene Name	brl1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	692
Subcellular Localization	Nucleus .
Protein Description	E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation..
Protein Sequence	MSVVNESRKRRRLIHSEKETRRLDLGEEDDLELFQKEAAWRRSREYEHLTVLEKKLYEYWESLVLKLDHYVAAALENHEQSFEELEKITASLYQPDDNLQTLDLSLAEFSLIKDAQNYLNKYASYFQAHEPTLQKLAKFGSFKLKETPNVHEWIDQRQVHFTSMINYRTSQLKLALLKRKLSFFREALNSAELEWKRVQQDQLTSASERSIENIADDIPASEPKAILENGEGCLNDNDNISKLKNNFQSQADLMQANINSKLDELSQKSTRAAQLYVDIMGITDERVSREPHYLELKGVLSSNEEKIESINRDLSSLFEDIQFFISQRTKRQKDIIDLKLACVKEKQQLIKTLESSLTQIRNERDSLVAKQQMQYTNNLFFDDMMLLLSNLSNARVAILEGYSNRLCIWDRIERSKTGEMNNVLDEKEEISASSALEKLIKNNSCLEAELPSMYAAFDQSQSRLLKKYEELETKEKKALEMHYEKARATQKYFAAMKARDILMTEKKTLKLAENKEHDYIGKLQEREHALTKYESSLKAELEVYKQIKEIYGKHSVEVLTEDKHLQVKQTKLTQKLEDLIESVQKSGEKLMIMHQKLFHLQEEHTILSIKASYNKKESHLINQAYETQEAQVYKGMLKCSVCNFSNWKSKLIPNCGHAFCSNCMEPFYEHKTSTCPQCETPFSVSDILTIHL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
182	Phosphorylation	ALLKRKLSFFREALN HHHHHHHHHHHHHHH	25.93	25720772
210	Phosphorylation	LTSASERSIENIADD HCCCCHHHHHHHHHC	30.15	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BRL1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BRL1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BRL1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SLX8_SCHPO	slx8	physical	17762865
YEG5_SCHPO	mga2	genetic	19547744

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BRL1_SCHPO

Related Literatures of Post-Translational Modification