FKBP4_SCHPO - dbPTM
FKBP4_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FKBP4_SCHPO
UniProt AC O74191
Protein Name FK506-binding protein 39 kDa
Gene Name fkbp39 {ECO:0000303|PubMed:10544281}
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 361
Subcellular Localization Nucleus . Nucleus, nucleolus .
Protein Description PPIase that acts as a histone chaperone. [PubMed: 14981505 Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression (By similarity]
Protein Sequence MSLPIAVYSLSVKGKDVPAVEESTDASIHLTMASIDAGEKSNKPTTLLVKVRPRIPVEDEDDEELDEQMQELLEESQREFVLCTLKPGSLYQQPLNLTITPGDEVFFSASGDATIHLSGNFLVDEEDEEEEESDEDYDLSPTEEDLVETVSGDEESEEESESEDNSASEEDELDSAPAKKAQVKKKRTKDESEQEEAASPKKNNTKKQKVEGTPVKEKKVAFAEKLEQGPTGPAAKKEKQQASSNAPSSPKTRTLKGGVVVTDVKTGSGASATNGKKVEMRYIGKLENGKVFDKNTKGKPFAFILGRGEVIRGWDVGVAGMQEGGERKITIPAPMAYGNQSIPGIPKNSTLVFEVKLVRVH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
41PhosphorylationSIDAGEKSNKPTTLL
EECCCCCCCCCEEEE		45.8725720772
188PhosphorylationAQVKKKRTKDESEQE
HHHHHCCCCCHHHHH		52.2925720772
192PhosphorylationKKRTKDESEQEEAAS
HCCCCCHHHHHHHHC		55.5028889911
199PhosphorylationSEQEEAASPKKNNTK
HHHHHHHCCCCCCCC		44.2828889911
205PhosphorylationASPKKNNTKKQKVEG
HCCCCCCCCCCEECC		49.3529996109
213PhosphorylationKKQKVEGTPVKEKKV
CCCEECCCCCCHHHH		16.0528889911
243PhosphorylationKKEKQQASSNAPSSP
HHHHHHHHCCCCCCC		21.5629996109
244PhosphorylationKEKQQASSNAPSSPK
HHHHHHHCCCCCCCC		39.7729996109
248PhosphorylationQASSNAPSSPKTRTL
HHHCCCCCCCCCCEE		57.7921712547
249PhosphorylationASSNAPSSPKTRTLK
HHCCCCCCCCCCEEE		29.3828889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FKBP4_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FKBP4_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FKBP4_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AMO1_SCHPOamo1genetic
18818364
YBPD_SCHPOSPBC16H5.13genetic
18818364
PPK23_SCHPOcdk11genetic
18818364
SERB_SCHPOser2genetic
18818364
CLR4_SCHPOclr4genetic
18818364
POB3_SCHPOpob3genetic
18818364
CLR3_SCHPOclr3genetic
18818364
TAS3_SCHPOtas3genetic
18818364
DSC1_SCHPOdsc1genetic
18818364
RIK1_SCHPOrik1genetic
18818364
ERS1_SCHPOers1genetic
18818364
BDF1_SCHPObdf1genetic
18818364
HRR1_SCHPOhrr1genetic
18818364
CAF1_SCHPOcaf1genetic
18818364
DCR1_SCHPOdcr1genetic
18818364
CCR4_SCHPOccr4genetic
18818364
MU154_SCHPOmug154genetic
18818364
RAF1_SCHPOraf1genetic
18818364
CID12_SCHPOcid12genetic
18818364
AGO1_SCHPOago1genetic
18818364
ALP14_SCHPOalp14genetic
18818364
RAF2_SCHPOraf2genetic
18818364
ELP5_SCHPOelp5genetic
18818364
COPE_SCHPOsec28genetic
18818364
ASK1_SCHPOask1genetic
18818364
FBH1_SCHPOfbh1genetic
18818364
ELP1_SCHPOelp1genetic
18818364
ELP6_SCHPOelp6genetic
18818364
SNF8_SCHPOdot2genetic
18818364
AIR1_SCHPOair1genetic
18818364
ELP4_SCHPOelp4genetic
18818364
HEL2_SCHPOSPCC1223.01genetic
18818364
URK1_SCHPOSPCC162.11cgenetic
18818364
BMT5_SCHPOSPCC1919.13cgenetic
18818364
ELP2_SCHPOelp2genetic
18818364
DDB1_SCHPOddb1genetic
22681890
RIK1_SCHPOrik1genetic
22681890
ARB1_SCHPOarb1genetic
22681890
YE7A_SCHPOSPAC4A8.10genetic
22681890
NSE6_SCHPOnse6genetic
22681890
SCE3_SCHPOsce3genetic
22681890
SVF1_SCHPOSPCC584.11cgenetic
22681890
REB1_SCHPOreb1genetic
22681890
YEYA_SCHPOcsc4genetic
22681890
YG1G_SCHPOSPBC83.16cgenetic
22681890
SWI6_SCHPOswi6genetic
22681890
PPK14_SCHPOppk14genetic
22681890
YEG3_SCHPOpcf2genetic
22681890
MUG60_SCHPOSPBC28E12.02genetic
22681890
YM06_SCHPOSPAC212.06cgenetic
22681890
RAF2_SCHPOraf2genetic
22681890
PYP1_SCHPOpyp1genetic
22681890
YNVD_SCHPOfar10genetic
22681890
ELP6_SCHPOelp6genetic
22681890
PROB_SCHPOSPAC17H9.13cgenetic
22681890
ATP10_SCHPOatp10genetic
22681890
UCP6_SCHPOucp6genetic
22681890
CSK2C_SCHPOckb2genetic
22681890
YHM5_SCHPOSPBC1271.05cgenetic
22681890
MEX67_SCHPOmex67genetic
22681890
YN8E_SCHPOSPBP35G2.14genetic
22681890
MGR2_SCHPOmgr2genetic
22681890
RAD55_SCHPOrad55genetic
22681890
RAD17_SCHPOrad17genetic
22681890
ARP8_SCHPOarp8genetic
22681890
SDH3_SCHPOsdh3genetic
22681890
CLR4_SCHPOclr4genetic
22681890
SEY1_SCHPOSPAC222.14cgenetic
22681890
CHP1_SCHPOchp1genetic
22681890
YNSI_SCHPOSPBC18H10.18cgenetic
22681890
GSHB_SCHPOgsa1genetic
22681890
BUN62_SCHPObun62genetic
22681890
OBP1_SCHPOSPBC646.08cgenetic
22681890
OTC_SCHPOarg3genetic
22681890
LEM2_SCHPOlem2genetic
22681890
PAB2_SCHPOpab2genetic
22681890
MUG80_SCHPOmug80genetic
22681890
YCD2_SCHPOpxd1genetic
22681890
ARP42_SCHPOarp42genetic
22681890
TOC1_SCHPOtoc1genetic
22681890
UBA4_SCHPOSPAC2G11.10cgenetic
22681890
UBC15_SCHPOubc15genetic
22681890
DMA1_SCHPOdma1genetic
22681890
NOT3_SCHPOnot3genetic
22681890
RAD57_SCHPOrad57genetic
22681890
MUG93_SCHPOmug93genetic
22681890
YI7H_SCHPOSPAC977.17genetic
22681890
ING2_SCHPOpng2genetic
22681890
DSK1_SCHPOdsk1genetic
22681890
ATP14_SCHPOatp14genetic
22681890
YCPF_SCHPOSPCC663.15cgenetic
22681890
YO74_SCHPOSPBC1921.04cgenetic
22681890
ERS1_SCHPOers1genetic
22681890
HUS1_SCHPOhus1genetic
22681890
PYRD_SCHPOura3genetic
22681890
PUN1_SCHPOpun1genetic
22681890
AZET_SCHPOaca1genetic
22681890
RAF1_SCHPOraf1genetic
22681890
ELP1_SCHPOelp1genetic
22681890
GAR2_SCHPOgar2genetic
22681890
YCO6_SCHPOnap1genetic
22681890
RDP1_SCHPOrdp1genetic
22681890
YQ9H_SCHPOSPCC18.17cgenetic
22681890
ROK1_SCHPOrok1genetic
22681890
ASK1_SCHPOask1genetic
22681890
GLD1_SCHPOgld1genetic
22681890
YD56_SCHPOSPAC6C3.06cgenetic
22681890
YBPD_SCHPOSPBC16H5.13genetic
22681890
PPK38_SCHPOppk38genetic
22681890
ACH1_SCHPOSPAC1952.09cgenetic
22681890
TOM70_SCHPOtom70genetic
22681890
TRM82_SCHPOSPCC18.13genetic
22681890
OS9_SCHPOSPAC227.11cgenetic
22681890
FFT3_SCHPOfft3genetic
22681890
ALAT_SCHPOSPBC582.08genetic
22681890
SKI3_SCHPOSPCC1919.05genetic
22681890
DAD2_SCHPOdad2genetic
22681890
IWR1_SCHPOiwr1genetic
22681890
YAS5_SCHPOmms1genetic
22681890
OAC1_SCHPOoac1genetic
22681890
MU154_SCHPOmug154genetic
22681890
YNF8_SCHPOSPBC17A3.08genetic
22681890
TFS2_SCHPOtfs1genetic
22681890
YK42_SCHPOtos4genetic
22681890
CSK1_SCHPOcsk1genetic
22681890
STG1_SCHPOstg1genetic
22681890
SODM_SCHPOSPAC1486.01genetic
22681890
YCV4_SCHPOSPCC777.04genetic
22681890
ASE1_SCHPOase1genetic
22681890
YNT3_SCHPOSPBC9B6.03genetic
22681890
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FKBP4_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-192; THR-213 ANDSER-249, AND MASS SPECTROMETRY.

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