CID12_SCHPO - dbPTM
CID12_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CID12_SCHPO
UniProt AC O74518
Protein Name Poly(A) RNA polymerase cid12
Gene Name cid12
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 336
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-directed RNA polymerase complex (RDRC) which is involved in the generation of small interfering RNAs (siRNAs) and mediate their association with the RNA-induced transcriptional silencing (RITS) complex. RITS acts as a priming complex for dsRNA synthesis at the site of non-coding centromeric RNA..
Protein Sequence MGKVLLELHSVPWNEEGLSDNARLYSFLEFVSPKIEELKYRKLLLEKLQTHIREVVLDAELQVYGSMYIGTTLSISDVDVSLKSPRVGELEKRRVTMVLRKYLDADADFHSSARVPRINLVDVSGIGVDLTFGNDKACRTAELQKAYNEEHPIFGRLLMLLKHWLFERDLENVHHGGIASCALSYMLIGWLEMRFHKKGIDSEVQPIRALLQKFFYFWGVEWTYELFVLRPLTGQIVPKLQKGWLNEVQPNLLSIEDPIDRNNDIGKQSFQISMIKAAFVASANELLSDKTWFSTFAITEDEMFLCKQFENVINTKRSLVEGYDSDTESDELQAGG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
325PhosphorylationSLVEGYDSDTESDEL
HHHCCCCCCCCCHHH		37.6428889911
327PhosphorylationVEGYDSDTESDELQA
HCCCCCCCCCHHHCC		41.1428889911
329PhosphorylationGYDSDTESDELQAGG
CCCCCCCCHHHCCCC		38.1828889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CID12_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CID12_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CID12_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BUB1_SCHPObub1genetic
16738311
DPOD3_SCHPOcdc27genetic
16738311
RDP1L_SCHPOdeb1physical
15607976
HRR1_SCHPOhrr1physical
15607976
TBB_SCHPOnda3genetic
16738311
RDP1_SCHPOrdp1genetic
20178743
MST2_SCHPOmst2genetic
21289066
RAF2_SCHPOraf2genetic
18818364
TAS3_SCHPOtas3physical
22474355
RDP1_SCHPOrdp1physical
22474355
HRR1_SCHPOhrr1physical
22474355
TAS3_SCHPOtas3physical
22733737
HRR1_SCHPOhrr1physical
22733737
ARB1_SCHPOarb1genetic
22681890
MPH1L_SCHPOmph1genetic
22681890
ATG22_SCHPOatg22genetic
22681890
SFT1_SCHPOsft1genetic
22681890
YG58_SCHPOSPBC56F2.08cgenetic
22681890
ERO11_SCHPOero11genetic
22681890
BQT3_SCHPObqt3genetic
22681890
FIN1_SCHPOfin1genetic
22681890
MU130_SCHPOmug130genetic
22681890
YL33_SCHPOsil1genetic
22681890
YAY3_SCHPOSPAC4H3.03cgenetic
22681890
YA33_SCHPOSPAC18B11.03cgenetic
22681890
EIF2A_SCHPOSPBC4B4.04genetic
22681890
RAF2_SCHPOraf2genetic
22681890
ARP6_SCHPOarp6genetic
22681890
IMA3_SCHPOSPCC550.11genetic
22681890
PDX1_SCHPOsnz1genetic
22681890
RT109_SCHPOrtt109genetic
22681890
RS17B_SCHPOrps1702genetic
22681890
TASP1_SCHPOSPAC823.09cgenetic
22681890
SIR2_SCHPOsir2genetic
22681890
YJNG_SCHPOSPCC24B10.16cgenetic
22681890
UFD2_SCHPOufd2genetic
22681890
ARGJ_SCHPOSPBC1271.14genetic
22681890
RBSK_SCHPOSPBC16G5.02cgenetic
22681890
YGN3_SCHPOSPBC2D10.03cgenetic
22681890
PGT1_SCHPOpgt1genetic
22681890
WTF25_SCHPOwtf25genetic
22681890
OTU2_SCHPOotu2genetic
22681890
YN8B_SCHPOSPBP35G2.11cgenetic
22681890
SWD1_SCHPOswd1genetic
22681890
OBP1_SCHPOSPBC646.08cgenetic
22681890
KCC2_SCHPOcmk2genetic
22681890
YAJE_SCHPOSPAC30D11.14cgenetic
22681890
PPK4_SCHPOire1genetic
22681890
CSN1_SCHPOcsn1genetic
22681890
ATG11_SCHPOatg11genetic
22681890
YMR1_SCHPOymr1genetic
22681890
HHP2_SCHPOhhp2genetic
22681890
CAO2_SCHPOcao2genetic
22681890
FSV1_SCHPOfsv1genetic
22681890
GBB_SCHPOgit5genetic
22681890
VPS38_SCHPOvps38genetic
22681890
NTO1_SCHPOnto1genetic
22681890
NU124_SCHPOnup124genetic
22681890
SSN3_SCHPOsrb10genetic
22681890
YE98_SCHPOerp2genetic
22681890
MUG20_SCHPOmug20genetic
22681890
COQ10_SCHPOcoq10genetic
22681890
YQJ7_SCHPOSPCC1840.07cgenetic
22681890
ALG5_SCHPOalg5genetic
22681890
YO48_SCHPOSPBC36B7.08cgenetic
22681890
AROG_SCHPOSPAP8A3.07cgenetic
22681890
ERS1_SCHPOers1genetic
22681890
FKBP4_SCHPOfkbp39genetic
22681890
YGVA_SCHPOdef1genetic
22681890
GAR2_SCHPOgar2genetic
22681890
CLR3_SCHPOclr3genetic
22681890
MU172_SCHPOmsd1genetic
22681890
MST2_SCHPOmst2genetic
22681890
ERFD_SCHPOerf4genetic
22681890
RDP1_SCHPOrdp1genetic
22681890
RL27A_SCHPOrpl2701genetic
22681890
OMH5_SCHPOomh5genetic
22681890
PPK38_SCHPOppk38genetic
22681890
OAZ_SCHPOspa1genetic
22681890
YI75_SCHPOSPAC977.05cgenetic
22681890
YQO4_SCHPOSPCC569.04genetic
22681890
YKP3_SCHPOSPAC589.03cgenetic
22681890
YHZ7_SCHPOSPBC21B10.07genetic
22681890
MID1_SCHPOmid1genetic
22681890
YJC7_SCHPOSPCC736.07cgenetic
22681890
MUG87_SCHPOnup97genetic
22681890
YFE6_SCHPOgmh5genetic
22681890
YGNB_SCHPOnap2genetic
22681890
ARC1_SCHPOSPAC30C2.04genetic
22681890
YKEE_SCHPOSPAC1805.14genetic
22681890
RL7B_SCHPOrpl702genetic
22681890
YJH4_SCHPOSPCP31B10.04genetic
22681890
OMH6_SCHPOomh6genetic
22681890
SIR2_SCHPOsir2genetic
23572080
CLR3_SCHPOclr3genetic
23572080
DPOE_SCHPOcdc20genetic
16738311
ATF1_SCHPOatf1physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CID12_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325; THR-327 ANDSER-329, AND MASS SPECTROMETRY.

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