ERO11_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ERO11_SCHPO
• UniProt AC: O74401
• Protein Name: ERO1-like protein 1
• Gene Name: ero11
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 467
• Subcellular Localization: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Lumenal side .
• Protein Description: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly pdi1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on pdi1 to transfer oxidizing equivalent. Does not oxidize all pdi related proteins, suggesting that it can discriminate between pdi1 and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress..
• Protein Sequence: MIGITKLISIWNAIWNFLLLPEIIISQTDTSSTGIYQMQSKVRSLVPVLTERSDYFSYYRVNLYRSSCPLWENDNAMCSNQGCAVKSLNEIEIPKVWKKLSDFEPHSKKNDTKCNWKYNPDLDYCYLDNSTSPDEYVYVSLVQNPERFTGYAGDHSAAIWRSIYEQNCFVVDDDDNPSEQPKSNALFRPNQIPLNLFTENHDDTSLSPSVACLEKRMFNRIISGFHASISTHVCQNYYDVEEQRWTQNLDWWRAKVGSFPDRIENIFFNYALLHQALVQIATQMKNITSDSSFTFCPTDKDVDWRTHTAFEQLVYHAYQDRHVINREQFFADEEAKRFKDSFRKHFRDISRIMDCVGCDKCRLWGKVQITGYGTALKLLLEPETQLSDLRPEEVVALVNTFDRISHSVEATFWFSLKAKTNDTLDAIKALIYKTYRSPSKEILAFFIDQTWYLFYALFFICNVPRVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
110	N-linked_Glycosylation	FEPHSKKNDTKCNWK CCCCCCCCCCCCCCC	66.96	-
129	N-linked_Glycosylation	LDYCYLDNSTSPDEY CCEEEECCCCCCCCE	44.59	-
286	N-linked_Glycosylation	QIATQMKNITSDSSF HHHHHCCCCCCCCCC	37.11	-
421	N-linked_Glycosylation	FSLKAKTNDTLDAIK EEEECCCCCHHHHHH	39.29	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ERO11_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ERO11_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ERO11_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of ERO11_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.