UFD2_SCHPO - dbPTM
UFD2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UFD2_SCHPO
UniProt AC Q9HE05
Protein Name Ubiquitin conjugation factor E4
Gene Name ufd2
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1010
Subcellular Localization Cytoplasm . Nucleus .
Protein Description E4 ubiquitin chain-elongation enzyme specifically involved in polyubiquitin chain assembly. Binds to cdc48 and elongates mono- and diubiquitinated ERAD substrates presented by the ufd1-npl4-cdc48 (UNC) AAA ATPase complex to a chain length of 4 to 6 ubiquitin moieties. Delivers these polyubiquitinated substrates to downstream ERAD components, which target them to the proteasome. Enhances ubiquitination at 'Lys-48', but not at 'Lys-29' of the Ub moiety..
Protein Sequence MSDLEKIRLKRLAKLQQTNSEANSSKEPKESNIAPEPKKPDLKKRFIGSKATTSNSEQKEISPPVTSGAPKHRLFSKDEWMHFITCQALNITLSETDSSKYYLEGFKKDLEEEGSPLLFNENNVDSALLSRLSTTGNNTFSYLLQSWSFLYQYKKRLPKDENQDFKIHYLSLLKSLLVSYAGIVVMLPDTFNSETIDLAEVLIGAEGIPLEFLSEFVQRFEHENLDELFIPVLESLSLKIGLMNVDTVQMNVMQIILQLVSLKPIALLLPKLPSWNPTNNAGEIEYKTFLGRISSLSVFTQDVASRYFSNSTERSAQNISSSISSLKLTMSTYQDVLFQIFNTLIRTSTSLRESVLDFFAMVVNANHKRQSIQVNHFDITSDACMLNFSHVLSRLSEPFLDIGCSKIDRVQVEYFRRNPRVDIKEETKLNADQKASESFYSKPAEGSNNFISDIFFLNLAFHHYGVNATFKALEQLVQSIRDSEKLKERLETEQQNMSGSFQATRLTAQLSRLDQRLDLDRSFVHCYEIMLTQTSDTSRSFSFLNFVAIWLSRLADGQSSTYPKMPLSLPFNENAPEAFKCLPEYFIETITDYMLSLFKTSSSTLTLHSLEPLCEFCVSFLTQANYIKNPYLRAKLAEILYFGVQTHVGRSELLLDVVRTSKVATRWLLPALMAFYIEIESTGQSTQFYDKFNIRFYICEVFRTIWKQPAYFGKLEQEQKTNLPFFVKFVALMLNDATYLLDEALLKLTEIHNLQSLLADAISNSNSNQNVQESQSNLAAAERQASTYCQLGNETIFMLKLFTSSIPKAFCAVEIVDRLAAMLNYNLQALCGPKCSNLKVEDPTKYHFNAKTLLSIIFDVYLNLCNEPAFVEAVAHDGRSYSKEIFERATSIMTKHNLKSSFDIEAIKEFVNRVEAFRLQEATEEEDMGDIPDYFLDPLMFTIMKDPVVLPRSGISIDRSTIKAHLLSDATDPFNRTPLTLDDVTPNDTLREEINTFLKSKRNKHSRNSE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
31PhosphorylationSSKEPKESNIAPEPK
CCCCCCCCCCCCCCC		39.4021712547
62PhosphorylationNSEQKEISPPVTSGA
CCCCCCCCCCCCCCC		25.0128889911
315PhosphorylationFSNSTERSAQNISSS
HCCCCHHHHHHHHHH		28.1625720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UFD2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UFD2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UFD2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARP42_SCHPOarp42genetic
18818364
RYH1_SCHPOryh1genetic
18818364
RDP1_SCHPOrdp1genetic
18818364
AMO1_SCHPOamo1genetic
18818364
SWD2_SCHPOswd2genetic
18818364
SGF29_SCHPOsgf29genetic
18818364
ASK1_SCHPOask1genetic
18818364
NGG1_SCHPOngg1genetic
18818364
YB3C_SCHPOcay1genetic
18818364
HIR1_SCHPOhip1genetic
18818364
SWD3_SCHPOswd3genetic
18818364
YO48_SCHPOSPBC36B7.08cgenetic
18818364
CLR4_SCHPOclr4genetic
18818364
TAS3_SCHPOtas3genetic
18818364
HPC2_SCHPOhip4genetic
18818364
PP2C2_SCHPOptc2genetic
18818364
ERS1_SCHPOers1genetic
18818364
PEF1_SCHPOpef1genetic
18818364
DCR1_SCHPOdcr1genetic
18818364
SET1_SCHPOset1genetic
18818364
CCR4_SCHPOccr4genetic
18818364
SPP1_SCHPOspf1genetic
18818364
RAF1_SCHPOraf1genetic
18818364
AGO1_SCHPOago1genetic
18818364
VPH2_SCHPOvph2genetic
18818364
ALP14_SCHPOalp14genetic
18818364
RAF2_SCHPOraf2genetic
18818364
RAD26_SCHPOrad26genetic
18818364
LUB1_SCHPOlub1genetic
18818364
EI2BA_SCHPOSPCC11E10.07cgenetic
18818364
2AD1_SCHPOpar1genetic
18818364
RIK1_SCHPOrik1genetic
22681890
YCJ6_SCHPOSPCC63.06genetic
22681890
RYH1_SCHPOryh1genetic
22681890
SFT1_SCHPOsft1genetic
22681890
MLH1_SCHPOmlh1genetic
22681890
YHJ1_SCHPOSPBPB10D8.01genetic
22681890
YDEF_SCHPOSPAC12B10.15cgenetic
22681890
YC83_SCHPOSPCC622.03cgenetic
22681890
PPK33_SCHPOppk33genetic
22681890
SWR1_SCHPOswr1genetic
22681890
MUG35_SCHPOmug35genetic
22681890
SSR3_SCHPOssr3genetic
22681890
EXG3_SCHPOexg3genetic
22681890
PPK14_SCHPOppk14genetic
22681890
UBLH1_SCHPOuch1genetic
22681890
YAOE_SCHPOSPAC11D3.14cgenetic
22681890
PAC2_SCHPOpac2genetic
22681890
YHAH_SCHPOSPBC409.17cgenetic
22681890
MFR1_SCHPOmfr1genetic
22681890
YCGK_SCHPOSPCC16C4.20cgenetic
22681890
LUB1_SCHPOlub1genetic
22681890
SPN5_SCHPOspn5genetic
22681890
YER7_SCHPOSPAC2F3.07cgenetic
22681890
PDX1_SCHPOsnz1genetic
22681890
MU134_SCHPOSPAC10F6.15genetic
22681890
YAG1_SCHPOSPAC12G12.01cgenetic
22681890
SWD3_SCHPOswd3genetic
22681890
AP3M_SCHPOapm3genetic
22681890
PLB2_SCHPOSPAC1A6.03cgenetic
22681890
LEUC_SCHPOleu2genetic
22681890
YF69_SCHPOSPAC23C4.09cgenetic
22681890
GHT6_SCHPOght6genetic
22681890
NEM1_SCHPOnem1genetic
22681890
ALG9_SCHPOalg9genetic
22681890
DAD1_SCHPOdad1genetic
22681890
AATC_SCHPOSPAC10F6.13cgenetic
22681890
GYP1_SCHPOgyp1genetic
22681890
YN25_SCHPOprt1genetic
22681890
GIT3_SCHPOgit3genetic
22681890
ZRG17_SCHPOzrg17genetic
22681890
LAG1_SCHPOlag1genetic
22681890
ASH2_SCHPOash2genetic
22681890
PSD3_SCHPOpsd3genetic
22681890
GBB_SCHPOgit5genetic
22681890
PFD3_SCHPOpac10genetic
22681890
DCOR_SCHPOspe1genetic
22681890
YL8H_SCHPOSPAC25B8.17genetic
22681890
YEMB_SCHPOSPAC29B12.11cgenetic
22681890
YF65_SCHPOSPAC23C4.05cgenetic
22681890
MMS19_SCHPOmms19genetic
22681890
YFM8_SCHPOSPAC222.08cgenetic
22681890
CORO_SCHPOcrn1genetic
22681890
AROG_SCHPOSPAP8A3.07cgenetic
22681890
CYB51_SCHPOSPBC29A10.16cgenetic
22681890
ELP3_SCHPOelp3genetic
22681890
VIPI_SCHPOvip1genetic
22681890
ATP11_SCHPOatp11genetic
22681890
CLR3_SCHPOclr3genetic
22681890
YBKD_SCHPOgmh6genetic
22681890
YOO8_SCHPOSPBC887.08genetic
22681890
SET1_SCHPOset1genetic
22681890
MED1_SCHPOpmc2genetic
22681890
PLPL_SCHPOptl2genetic
22681890
PFD6_SCHPOSPAC3A11.13genetic
22681890
ASK1_SCHPOask1genetic
22681890
SHR3_SCHPOpsh3genetic
22681890
YHAG_SCHPOsaw1genetic
22681890
YQO4_SCHPOSPCC569.04genetic
22681890
RGA3_SCHPOrga3genetic
22681890
RL17B_SCHPOrpl1702genetic
22681890
RS17A_SCHPOrps1701genetic
22681890
GYP10_SCHPOgyp10genetic
22681890
IVN1_SCHPOivn1genetic
22681890
CIS4_SCHPOcis4genetic
22681890
SPM1_SCHPOpmk1genetic
22681890
RL19B_SCHPOrpl1902genetic
22681890
UBP2_SCHPOubp2genetic
22681890
YAB4_SCHPOSPAC2G11.04genetic
22681890
YFE6_SCHPOgmh5genetic
22681890
ERG31_SCHPOerg31genetic
22681890
YGX1_SCHPOSPBC2G5.01genetic
22681890
YFFE_SCHPOSPAC1687.14cgenetic
22681890
TCG1_SCHPOtcg1genetic
22681890
YQK8_SCHPOSPCC1494.08cgenetic
22681890
SDS23_SCHPOsds23physical
23640764
SWI10_SCHPOswi10physical
20427284
DSK2_SCHPOdph1physical
20427284
DSK2_YEASTDSK2physical
20427284
RAD23_YEASTRAD23physical
20427284
DSK2_SCHPOdph1physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UFD2_SCHPO

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Related Literatures of Post-Translational Modification

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