| UniProt ID | CLR4_SCHPO | |
|---|---|---|
| UniProt AC | O60016 | |
| Protein Name | Histone-lysine N-methyltransferase, H3 lysine-9 specific | |
| Gene Name | clr4 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 490 | |
| Subcellular Localization | Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body . Chromosome . | |
| Protein Description | Histone methyltransferase. Catalytic component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci.. | |
| Protein Sequence | MSPKQEEYEVERIVDEKLDRNGAVKLYRIRWLNYSSRSDTWEPPENLSGCSAVLAEWKRRKRRLKGSNSDSDSPHHASNPHPNSRQKHQHQTSKSVPRSQRFSRELNVKKENKKVFSSQTTKRQSRKQSTALTTNDTSIILDDSLHTNSKKLGKTRNEVKEESQKRELVSNSIKEATSPKTSSILTKPRNPSKLDSYTHLSFYEKRELFRKKLREIEGPEVTLVNEVDDEPCPSLDFQFISQYRLTQGVIPPDPNFQSGCNCSSLGGCDLNNPSRCECLDDLDEPTHFAYDAQGRVRADTGAVIYECNSFCSCSMECPNRVVQRGRTLPLEIFKTKEKGWGVRSLRFAPAGTFITCYLGEVITSAEAAKRDKNYDDDGITYLFDLDMFDDASEYTVDAQNYGDVSRFFNHSCSPNIAIYSAVRNHGFRTIYDLAFFAIKDIQPLEELTFDYAGAKDFSPVQSQKSQQNRISKLRRQCKCGSANCRGWLFG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 71 | Phosphorylation | LKGSNSDSDSPHHAS HCCCCCCCCCCCCCC | 39.55 | 29996109 | |
| 73 | Phosphorylation | GSNSDSDSPHHASNP CCCCCCCCCCCCCCC | 30.04 | 29996109 | |
| 109 | Sumoylation | FSRELNVKKENKKVF HHHHHCCCHHHHHHC | 53.98 | - | |
| 127 | Methylation | TTKRQSRKQSTALTT HHCCHHHCCCCCCCC | 54.57 | 30051891 | |
| 160 | Sumoylation | GKTRNEVKEESQKRE CCHHHHHHHHHHHHH | 49.97 | - | |
| 455 | Methylation | TFDYAGAKDFSPVQS CCCCCCCCCCCCCCC | 59.39 | 30051891 | |
| 458 | Phosphorylation | YAGAKDFSPVQSQKS CCCCCCCCCCCCCHH | 34.00 | 28889911 | |
| 462 | Phosphorylation | KDFSPVQSQKSQQNR CCCCCCCCCHHHHHH | 39.55 | 24763107 | |
| 464 | Methylation | FSPVQSQKSQQNRIS CCCCCCCHHHHHHHH | 56.32 | 30051891 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CLR4_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CLR4_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CLR4_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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