| UniProt ID | TPZ1_SCHPO | |
|---|---|---|
| UniProt AC | O14246 | |
| Protein Name | Protection of telomeres protein tpz1 | |
| Gene Name | tpz1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 508 | |
| Subcellular Localization | Chromosome, telomere . Nucleus . | |
| Protein Description | Telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang and involved in telomere length regulation. recruits poz1 and ccq1 to telomeres, regulating telomere length negatively and positivels respectively.. | |
| Protein Sequence | MSNCLKHPWLENGLLNLIKNADVLPIRVFKCQPLQIFEYIRYEHPIRCKLSDTEFYIEAEFSSQSISDLNNFTEKRITSLRGGIVTLGNFLIHLIPSQSGIIPWIQVESFNFQGCEGAVFGNPKAITTSALFNALLQSPYLAALANEFNRSIKEGSSYQEASLSQQEKPNDNTSNSRDIKNNIQFHWKNMTSLSIEECIIPKGQQLILEKESEENTTHGIYLEERKMAQGLHNSVSETPEVKQEDNDEDLDAYSWSSSTDSAGEIPSLPTNRKILEKIAEKPPPFESPLEDDETPDQTNEHEANQVNVSQLPLNPRGSGISGRPVESTEQLNSSLTIERSQSIQSTDSKQRVETQSHRRSKIEIFDAQDELFDRSICTTIDDSTGKLLNAEETPIKTGDLHSTSASSVISCTPPAINFTSDICNEQIELEYKRKPIPDYDFMKGLETTLQELYVEHQSKKRRLELFQLTNNHQKNSEACEMCRLGLPHGSFFELLRDWKKIEEFRNKS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 164 | Phosphorylation | SYQEASLSQQEKPND CCCCCCCCCCCCCCC | 27.59 | 29996109 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TPZ1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TPZ1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TPZ1_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CCQ1_SCHPO | ccq1 | physical | 22101932 | |
| ULP2_SCHPO | ulp2 | genetic | 22681890 | |
| YE08_SCHPO | SPAC17H9.08 | genetic | 22681890 | |
| YIDH_SCHPO | SPAC227.17c | genetic | 22681890 | |
| POZ1_SCHPO | poz1 | physical | 24013504 | |
| CCQ1_SCHPO | ccq1 | physical | 24013504 | |
| POT1_SCHPO | pot1 | physical | 24013504 | |
| POZ1_SCHPO | poz1 | physical | 24711392 | |
| POT1_SCHPO | pot1 | physical | 24711392 | |
| CCQ1_SCHPO | ccq1 | physical | 24711392 | |
| TERT_SCHPO | trt1 | physical | 25131669 | |
| CCQ1_SCHPO | ccq1 | physical | 25131669 | |
| POZ1_SCHPO | poz1 | physical | 26365187 | |
| CCQ1_SCHPO | ccq1 | physical | 26365187 | |
| POT1_SCHPO | pot1 | physical | 26365187 | |
| POT1_SCHPO | pot1 | genetic | 26365187 | |
| POZ1_SCHPO | poz1 | physical | 26988418 | |
| MST2_SCHPO | mst2 | genetic | 26988418 | |
| CCQ1_SCHPO | ccq1 | physical | 26354422 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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