SET2_SCHPO - dbPTM
SET2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SET2_SCHPO
UniProt AC O14026
Protein Name Histone-lysine N-methyltransferase, H3 lysine-36 specific
Gene Name set2
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 798
Subcellular Localization Nucleus. Chromosome.
Protein Description Histone methyltransferase that methylates histone H3 to form H3K36me. Involved in transcription elongation as well as in transcription repression..
Protein Sequence MQTASSLSVLTPLNEENVDRKSSWSKDTIAVQAVGSSPSSSSSHDFESKEDAEGMNKDESAPSPSTSSPSSASSRSQSKYVRKEALPPQLFHHLDSAKDKALTTFEEIQECQYASANIGKPPENEAMICDCRPHWVDGVNVACGHGSNCINRMTSIECTDEDNVCGPSCQNQRFQRHEFAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHSCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQPCYCGEPCCVGYIGGKTQTEAQSKLPENVREALGIEDEEDSWENITARRQRRKKGIDETSKIIEEVQPTPLTSESATKVIGVLLQTKDDLLTRKLMERIFLTSDPSVCRSIIALRGYNIFGLMLKKFSIDIEFILRSIKTMLSWPRLTRNKIQDSNIEPVVQEFCDHENEEVKDHAKTLLKEWESLEIAYRIPRRKPGQVAPQSTNAEPSNNQSNPPLRDQEPQRGDKGDIKSAINNSTEDLSKKHPALHSSRPSDSRSRSKFGNDYQSHSKHNLFRKNSFPKRRRLSNSDTPSETTTPNNEQEQVSNQANKVDLNKIISAAMESVNQKNVLKAQKEEEERIAQQKREEKRRLAYEESLKRHAKKLHEKKTKSSQDATIDHHLTSHSPESIAFKAVLAKFFANKTARYQEKLGKAEFKLRVKKMTEIILKKHIQLVLSKKEKALPDELSDSQQRKLRVWAFRYLDTVVSRSGTATTTPTDSPSIGESPKKAA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
36PhosphorylationIAVQAVGSSPSSSSS
EEEEECCCCCCCCCC		32.2624763107
37PhosphorylationAVQAVGSSPSSSSSH
EEEECCCCCCCCCCC		23.9129996109
48PhosphorylationSSSHDFESKEDAEGM
CCCCCCCCHHHHCCC		41.1424763107
60PhosphorylationEGMNKDESAPSPSTS
CCCCCCCCCCCCCCC		56.4629996109
63PhosphorylationNKDESAPSPSTSSPS
CCCCCCCCCCCCCCC		31.0625720772
65PhosphorylationDESAPSPSTSSPSSA
CCCCCCCCCCCCCCC		45.3029996109
66PhosphorylationESAPSPSTSSPSSAS
CCCCCCCCCCCCCCC		36.2924763107
67PhosphorylationSAPSPSTSSPSSASS
CCCCCCCCCCCCCCC		44.5928889911
68PhosphorylationAPSPSTSSPSSASSR
CCCCCCCCCCCCCCC		28.9625720772
70PhosphorylationSPSTSSPSSASSRSQ
CCCCCCCCCCCCCHH		40.2529996109
544PhosphorylationIKSAINNSTEDLSKK
HHHHHHCCHHHHHHH		28.7829996109
545PhosphorylationKSAINNSTEDLSKKH
HHHHHCCHHHHHHHC		35.3228889911
561PhosphorylationALHSSRPSDSRSRSK
HHHCCCCCCCCCCHH		47.2928889911
563PhosphorylationHSSRPSDSRSRSKFG
HCCCCCCCCCCHHCC		36.1728889911
594PhosphorylationFPKRRRLSNSDTPSE
CCCCCCCCCCCCCCC		32.2628889911
596PhosphorylationKRRRLSNSDTPSETT
CCCCCCCCCCCCCCC		39.2128889911
598PhosphorylationRRLSNSDTPSETTTP
CCCCCCCCCCCCCCC		28.6529996109
600PhosphorylationLSNSDTPSETTTPNN
CCCCCCCCCCCCCCH		50.0625720772
602PhosphorylationNSDTPSETTTPNNEQ
CCCCCCCCCCCCHHH		40.0625720772
604PhosphorylationDTPSETTTPNNEQEQ
CCCCCCCCCCHHHHH		31.2925720772
769PhosphorylationLRVWAFRYLDTVVSR
HHHHHHHHHHEECCC		11.5025720772
775PhosphorylationRYLDTVVSRSGTATT
HHHHEECCCCCCCCC		19.1825720772
777PhosphorylationLDTVVSRSGTATTTP
HHEECCCCCCCCCCC		32.7525720772
779PhosphorylationTVVSRSGTATTTPTD
EECCCCCCCCCCCCC		23.2925720772
781PhosphorylationVSRSGTATTTPTDSP
CCCCCCCCCCCCCCC		30.9229996109
782PhosphorylationSRSGTATTTPTDSPS
CCCCCCCCCCCCCCC		28.4529996109
783PhosphorylationRSGTATTTPTDSPSI
CCCCCCCCCCCCCCC		21.6028889911
785PhosphorylationGTATTTPTDSPSIGE
CCCCCCCCCCCCCCC		47.2028889911
787PhosphorylationATTTPTDSPSIGESP
CCCCCCCCCCCCCCC		24.0328889911
789PhosphorylationTTPTDSPSIGESPKK
CCCCCCCCCCCCCCC		47.3728889911
793PhosphorylationDSPSIGESPKKAA--
CCCCCCCCCCCCC--		36.4828889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SET2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SET2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SET2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RPB1_SCHPOrpb1physical
15798214
RPB2_SCHPOrpb2physical
15798214
CLR4_SCHPOclr4genetic
18216783
SWI6_SCHPOswi6genetic
18252195
H31_SCHPOhht3physical
24583182
RPB1_SCHPOrpb1physical
24583182
RPB2_SCHPOrpb2physical
24583182
RPB3_SCHPOrpb3physical
24583182
RPB4_SCHPOrpb4physical
24583182
RPAB1_SCHPOrpb5physical
24583182
RPB7_SCHPOrpb7physical
24583182
RPAP2_SCHPOrtr1physical
24583182
H31_SCHPOhht3genetic
28718400
RPB1_SCHPOrpb1physical
26792892
RPB2_SCHPOrpb2physical
26792892
RPB3_SCHPOrpb3physical
26792892
RPB4_SCHPOrpb4physical
26792892
RPAB1_SCHPOrpb5physical
26792892
RPB7_SCHPOrpb7physical
26792892
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SET2_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67; THR-545; SER-594;SER-596; THR-783; THR-785; SER-787; SER-789 AND SER-793, AND MASSSPECTROMETRY.

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