SWI6_SCHPO - dbPTM
SWI6_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SWI6_SCHPO
UniProt AC P40381
Protein Name Chromatin-associated protein swi6
Gene Name swi6
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 328
Subcellular Localization Nucleus .
Protein Description Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Involved in the repression of the silent mating-type loci MAT2 and MAT3. May compact MAT2/3 into a heterochromatin-like conformation which represses the transcription of these silent cassettes..
Protein Sequence MKKGGVRSYRRSSTSKRSVIDDDSEPELPSMTKEAIASHKADSGSSDNEVESDHESKSSSKKLKENAKEEEGGEEEEEDEYVVEKVLKHRMARKGGGYEYLLKWEGYDDPSDNTWSSEADCSGCKQLIEAYWNEHGGRPEPSKRKRTARPKKPEAKEPSPKSRKTDEDKHDKDSNEKIEDVNEKTIKFADKSQEEFNENGPPSGQPNGHIESDNESKSPSQKESNESEDIQIAETPSNVTPKKKPSPEVPKLPDNRELTVKQVENYDSWEDLVSSIDTIERKDDGTLEIYLTWKNGAISHHPSTITNKKCPQKMLQFYESHLTFRENE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12PhosphorylationGVRSYRRSSTSKRSV
CCCCCCCCCCCCCCC		29.0325720772
13PhosphorylationVRSYRRSSTSKRSVI
CCCCCCCCCCCCCCC		34.5825720772
14PhosphorylationRSYRRSSTSKRSVID
CCCCCCCCCCCCCCC		39.2425720772
15PhosphorylationSYRRSSTSKRSVIDD
CCCCCCCCCCCCCCC		28.1925720772
18PhosphorylationRSSTSKRSVIDDDSE
CCCCCCCCCCCCCCC		27.4528889911
24PhosphorylationRSVIDDDSEPELPSM
CCCCCCCCCCCCCCC		63.1428889911
30PhosphorylationDSEPELPSMTKEAIA
CCCCCCCCCCHHHHH		52.2724763107
38PhosphorylationMTKEAIASHKADSGS
CCHHHHHHCCCCCCC		21.2925720772
43PhosphorylationIASHKADSGSSDNEV
HHHCCCCCCCCCCCH		45.4925720772
45PhosphorylationSHKADSGSSDNEVES
HCCCCCCCCCCCHHC		38.1725720772
46PhosphorylationHKADSGSSDNEVESD
CCCCCCCCCCCHHCC		48.2425720772
52PhosphorylationSSDNEVESDHESKSS
CCCCCHHCCCCCHHH		49.8225720772
56PhosphorylationEVESDHESKSSSKKL
CHHCCCCCHHHHHHH		34.1225720772
103SumoylationGGYEYLLKWEGYDDP
CCCCEEEEEECCCCC		40.37-
159PhosphorylationKPEAKEPSPKSRKTD
CCCCCCCCCCCCCCC		46.1624763107
192PhosphorylationTIKFADKSQEEFNEN
HHEECHHHHHHHHHC		43.2924763107
203PhosphorylationFNENGPPSGQPNGHI
HHHCCCCCCCCCCCC		53.8728889911
212PhosphorylationQPNGHIESDNESKSP
CCCCCCCCCCCCCCH		45.1724763107
216PhosphorylationHIESDNESKSPSQKE
CCCCCCCCCCHHHHC		44.6929996109
218PhosphorylationESDNESKSPSQKESN
CCCCCCCCHHHHCCC		38.7828889911
220PhosphorylationDNESKSPSQKESNES
CCCCCCHHHHCCCCC		62.0628889911
224PhosphorylationKSPSQKESNESEDIQ
CCHHHHCCCCCCCCE		53.5921712547
227PhosphorylationSQKESNESEDIQIAE
HHHCCCCCCCCEEEC		44.8328889911
235PhosphorylationEDIQIAETPSNVTPK
CCCEEECCCCCCCCC		24.0128889911
237PhosphorylationIQIAETPSNVTPKKK
CEEECCCCCCCCCCC		51.8829996109
240PhosphorylationAETPSNVTPKKKPSP
ECCCCCCCCCCCCCC		33.3728889911
246PhosphorylationVTPKKKPSPEVPKLP
CCCCCCCCCCCCCCC		42.4428889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SWI6_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SWI6_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SWI6_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
JHD1_SCHPOepe1physical
16762840
SCC3_SCHPOpsc3genetic
16682348
SMC1_SCHPOpsm1genetic
16682348
SCC4_SCHPOssl3genetic
16682348
RAD21_SCHPOrad21genetic
11598266
RAD21_SCHPOrad21genetic
11780129
SCC3_SCHPOpsc3genetic
11780129
TBB_SCHPOnda3genetic
9722643
CLR4_SCHPOclr4physical
11283354
SIR2_SCHPOsir2physical
15545655
RAF1_SCHPOraf1physical
16040243
RAF2_SCHPOraf2physical
16040243
SCC3_SCHPOpsc3physical
11780129
CHP1_SCHPOchp1physical
12361567
PCR1_SCHPOpcr1physical
15292231
ATF1_SCHPOatf1physical
15292231
SWI2_SCHPOswi2physical
15537537
CLR3_SCHPOclr3physical
16246721
UBC9_SCHPOhus5physical
16168376
CHP1_SCHPOchp1physical
15976807
DCR1_SCHPOdcr1physical
15976807
CLR4_SCHPOclr4physical
15976807
SGO1_SCHPOsgo1physical
18716626
RAD57_SCHPOrad57genetic
18931302
FIN1_SCHPOfin1genetic
18931302
CHL1_SCHPOchl1genetic
18931302
ARK1_SCHPOark1genetic
17322402
BIR1_SCHPObir1genetic
17322402
PIC1_SCHPOpic1genetic
17322402
EAF3_SCHPOalp13genetic
18252195
SPF30_SCHPOspf30genetic
20028739
SGO2_SCHPOsgo2genetic
14730319
CHP2_SCHPOchp2genetic
20421495
SWI6_SCHPOswi6physical
21211724
HIR3_SCHPOhip3physical
21211723
HIR1_SCHPOhip1physical
21211723
SWI6_SCHPOswi6physical
21224386
CLR4_SCHPOclr4physical
21224386
JHD1_SCHPOepe1physical
21215368
YEM8_SCHPOclr5genetic
21253571
CDC18_SCHPOcdc18physical
21239883
MRC1_SCHPOmrc1genetic
18818364
TBCA_SCHPOalp31genetic
18818364
MCL1_SCHPOmcl1genetic
18818364
EME1_SCHPOeme1genetic
18818364
MPH1L_SCHPOmph1genetic
18818364
ABP1_SCHPOcbp1genetic
18818364
FKBP4_SCHPOfkbp39genetic
18818364
KLP6_SCHPOklp6genetic
18818364
ELP5_SCHPOelp5genetic
18818364
MAD2_SCHPOmad2genetic
18818364
YOU5_SCHPOpph3genetic
18818364
CLR3_SCHPOclr3genetic
18818364
TBA2_SCHPOatb2genetic
18818364
HPC2_SCHPOhip4genetic
18818364
RPA12_SCHPOrpa12genetic
18818364
CAF1_SCHPOcaf1genetic
18818364
MSH6_SCHPOmsh6genetic
18818364
CCR4_SCHPOccr4genetic
18818364
ELP2_SCHPOelp2genetic
18818364
ALP14_SCHPOalp14genetic
18818364
COPE_SCHPOsec28genetic
18818364
TAS3_SCHPOtas3genetic
18818364
HRR1_SCHPOhrr1genetic
18818364
DCR1_SCHPOdcr1genetic
18818364
JHD1_SCHPOepe1genetic
18818364
AGO1_SCHPOago1genetic
18818364
BIR1_SCHPObir1genetic
22264609
PIC1_SCHPOpic1genetic
22264609
CUT7_SCHPOcut7genetic
22264609
ARK1_SCHPOark1genetic
22264609
FLP1_SCHPOclp1genetic
22264609
KLP9_SCHPOklp9genetic
22264609
ERS1_SCHPOers1physical
22474355
MPH1L_SCHPOmph1genetic
22681890
RYH1_SCHPOryh1genetic
22681890
FLP1_SCHPOclp1genetic
22681890
BUB3_SCHPObub3genetic
22681890
YCGK_SCHPOSPCC16C4.20cgenetic
22681890
RAF2_SCHPOraf2genetic
22681890
SKH1_SCHPOpek1genetic
22681890
RNC1_SCHPOrnc1genetic
22681890
YAC5_SCHPOcph1genetic
22681890
RAD55_SCHPOrad55genetic
22681890
VIP1_SCHPOasp1genetic
22681890
RPA12_SCHPOrpa12genetic
22681890
CLR4_SCHPOclr4genetic
22681890
YF98_SCHPOnht10genetic
22681890
CG121_SCHPOcgi121genetic
22681890
MAL3_SCHPOmal3genetic
22681890
COM1_SCHPOctp1genetic
22681890
YAQD_SCHPOSPAC18G6.13genetic
22681890
MUG80_SCHPOmug80genetic
22681890
ARP42_SCHPOarp42genetic
22681890
CHL1_SCHPOchl1genetic
22681890
JHD1_SCHPOepe1genetic
22681890
MSH6_SCHPOmsh6genetic
22681890
FKBP4_SCHPOfkbp39genetic
22681890
MAD2_SCHPOmad2genetic
22681890
CLR3_SCHPOclr3genetic
22681890
MU172_SCHPOmsd1genetic
22681890
GMA12_SCHPOgma12genetic
22681890
PTPA1_SCHPOypa1genetic
22681890
CTK3_SCHPOlsg1genetic
22681890
CGM2_SCHPOmcs2genetic
22681890
TBA2_SCHPOatb2genetic
22681890
IMA2_SCHPOimp1genetic
22681890
SPM1_SCHPOpmk1genetic
22681890
KLP6_SCHPOklp6genetic
22681890
MCL1_SCHPOmcl1genetic
22681890
CHP2_SCHPOchp2genetic
23604080
SGO2_SCHPOsgo2genetic
20929775
MRC1_SCHPOmrc1genetic
23478021
MUS81_SCHPOmus81genetic
23478021
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SWI6_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24; SER-220; SER-227;THR-240 AND SER-246, AND MASS SPECTROMETRY.

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