COPE_SCHPO - dbPTM
COPE_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID COPE_SCHPO
UniProt AC O74767
Protein Name Probable coatomer subunit epsilon
Gene Name sec28
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 288
Subcellular Localization Cytoplasm. Golgi apparatus membrane
Peripheral membrane protein
Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane
Peripheral membrane protein
Cytoplasmic side. The coatomer is cytoplasmic or polymerized on the cytoplasmic side o
Protein Description The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity)..
Protein Sequence MFSWEASLSNELYFVRQYFYSGNYTKLFEIDTTSMSEKGLELTEIYMARAKLALGESLESIQSILTQKTPGSAAILALAGEGNMELIIDQHGNSDSVVQTLGAIFQIKNGSFDDAMDLLKKSVENLEAVALQVYIHLREHKIEAAEQTLKQALDWADEEIVLQLAQSWIKIVSGGVESYNDAFYVFEELNGTDSNPMTLTGMACADICLLRPEEALSSLKTALDSQPNYEEALSNMTTAITDLGPDAPSQAKNILSSFTNSSTLKLNDHLNEKAQEFDTFSTQFLSTA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
257PhosphorylationQAKNILSSFTNSSTL
HHHHHHHHCCCCCCC		32.4225720772
259PhosphorylationKNILSSFTNSSTLKL
HHHHHHCCCCCCCCC		35.8225720772
261PhosphorylationILSSFTNSSTLKLND
HHHHCCCCCCCCCCH		22.9525720772
262PhosphorylationLSSFTNSSTLKLNDH
HHHCCCCCCCCCCHH		39.5728889911
263PhosphorylationSSFTNSSTLKLNDHL
HHCCCCCCCCCCHHH		27.9425720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of COPE_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of COPE_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of COPE_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NGG1_SCHPOngg1genetic
18818364
TMA20_SCHPOtma20genetic
18818364
HIR1_SCHPOhip1genetic
18818364
PLMT_SCHPOcho1genetic
18818364
PPT1_SCHPOSPBC3F6.01cgenetic
18818364
DSK1_SCHPOdsk1genetic
18818364
YG58_SCHPOSPBC56F2.08cgenetic
18818364
PPK31_SCHPOppk31genetic
18818364
HPC2_SCHPOhip4genetic
18818364
PPME1_SCHPOSPBP4H10.17cgenetic
18818364
EI2BA_SCHPOSPCC11E10.07cgenetic
18818364
HEL2_SCHPOSPCC1223.01genetic
18818364
PP2C2_SCHPOptc2genetic
18818364
HIF2_SCHPOhif2genetic
18818364
PUS1_SCHPOpus1genetic
18818364
YQ9A_SCHPOSPCC18.10genetic
18818364
2AD1_SCHPOpar1genetic
18818364
AAKB_SCHPOamk2genetic
18818364
NUP60_SCHPOnup60genetic
18818364
SET1_SCHPOset1genetic
18818364
MU154_SCHPOmug154genetic
18818364
NOT2_SCHPOnot2genetic
18818364
RNC1_SCHPOrnc1genetic
18818364
VPH2_SCHPOvph2genetic
18818364
RAF2_SCHPOraf2genetic
18818364
YB33_SCHPOebs1genetic
18818364
CLR6_SCHPOclr6genetic
18818364
RAD14_SCHPOrhp14genetic
18818364
SNF8_SCHPOdot2genetic
18818364
PYRE_SCHPOura5genetic
18818364
TAS3_SCHPOtas3genetic
18818364
LUB1_SCHPOlub1genetic
18818364
NU131_SCHPOnup131genetic
18818364
AIR1_SCHPOair1genetic
18818364
PPIB_SCHPOcyp4genetic
18818364
RIK1_SCHPOrik1genetic
18818364
FFT2_SCHPOfft2genetic
18818364
RPA12_SCHPOrpa12genetic
18818364
ODPX_SCHPOpdx1genetic
18818364
ERS1_SCHPOers1genetic
18818364
BDF1_SCHPObdf1genetic
18818364
HRR1_SCHPOhrr1genetic
18818364
DCR1_SCHPOdcr1genetic
18818364
UAF30_SCHPOspp27genetic
18818364
CCR4_SCHPOccr4genetic
18818364
YC8F_SCHPOSPCC622.15cgenetic
18818364
JHD1_SCHPOepe1genetic
18818364
JMJ4_SCHPOjmj4genetic
18818364
CID12_SCHPOcid12genetic
18818364
COPA_SCHPOSPBPJ4664.04physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of COPE_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-262, AND MASSSPECTROMETRY.

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