| UniProt ID | NOT2_SCHPO | |
|---|---|---|
| UniProt AC | P87240 | |
| Protein Name | General negative regulator of transcription subunit 2 | |
| Gene Name | not2 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 306 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. NOT2 is required for the integrity of the complex. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity).. | |
| Protein Sequence | MSLANRLSHLNITGGNDFKASIGPSVGRQNEATNPWSSTSHSLENSAATVVNELQTTKEQKTPEQSTTANPLFPGNDFSDFNNHKSKLLGVITGKSTPSSQAEKSDTTNSKTGSTEELTETPADENAKQYMLESLLPIIRMEDSEMSTLQLGCDLAALGFDLAPVEEDRLISTNLFSPWAELNTKKPVSQPMFKLPACYKNVNPPPAISKIFQFSDETLFYIFYTMPRDVMQEAAAQELTNRNWRFHKELRVWLTPVPGMKPLQRTPQFERGYYMFFDPIHWKRIKKDFLLMYAALEDRAQSAVHS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSLANRLSH ------CCHHHHHHC | 35.87 | 29996109 | |
| 8 | Phosphorylation | MSLANRLSHLNITGG CCHHHHHHCCCCCCC | 23.77 | 29996109 | |
| 13 | Phosphorylation | RLSHLNITGGNDFKA HHHCCCCCCCCCCCC | 37.65 | 24763107 | |
| 62 | Phosphorylation | QTTKEQKTPEQSTTA HHCCCCCCCCCCCCC | 31.58 | 24763107 | |
| 67 | Phosphorylation | QKTPEQSTTANPLFP CCCCCCCCCCCCCCC | 29.62 | 29996109 | |
| 68 | Phosphorylation | KTPEQSTTANPLFPG CCCCCCCCCCCCCCC | 29.68 | 29996109 | |
| 79 | Phosphorylation | LFPGNDFSDFNNHKS CCCCCCCHHCCCCCH | 44.12 | 24763107 | |
| 93 | Phosphorylation | SKLLGVITGKSTPSS HHHEEEECCCCCCCH | 35.83 | 25720772 | |
| 96 | Phosphorylation | LGVITGKSTPSSQAE EEEECCCCCCCHHHH | 47.06 | 24763107 | |
| 97 | Phosphorylation | GVITGKSTPSSQAEK EEECCCCCCCHHHHH | 30.58 | 24763107 | |
| 99 | Phosphorylation | ITGKSTPSSQAEKSD ECCCCCCCHHHHHCC | 34.86 | 24763107 | |
| 105 | Phosphorylation | PSSQAEKSDTTNSKT CCHHHHHCCCCCCCC | 31.52 | 25720772 | |
| 107 | Phosphorylation | SQAEKSDTTNSKTGS HHHHHCCCCCCCCCC | 34.66 | 25720772 | |
| 108 | Phosphorylation | QAEKSDTTNSKTGST HHHHCCCCCCCCCCH | 42.35 | 25720772 | |
| 110 | Phosphorylation | EKSDTTNSKTGSTEE HHCCCCCCCCCCHHH | 29.51 | 25720772 | |
| 112 | Phosphorylation | SDTTNSKTGSTEELT CCCCCCCCCCHHHHH | 35.86 | 29996109 | |
| 114 | Phosphorylation | TTNSKTGSTEELTET CCCCCCCCHHHHHCC | 37.57 | 24763107 | |
| 115 | Phosphorylation | TNSKTGSTEELTETP CCCCCCCHHHHHCCC | 34.52 | 29996109 | |
| 302 | Phosphorylation | ALEDRAQSAVHS--- HHHHHHHHHHCC--- | 31.13 | 21712547 | |
| 306 | Phosphorylation | RAQSAVHS------- HHHHHHCC------- | 35.01 | 24763107 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NOT2_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NOT2_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NOT2_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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