MEX67_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEX67_SCHPO
• UniProt AC: Q9Y8G3
• Protein Name: mRNA export factor mex67
• Gene Name: mex67
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 596
• Subcellular Localization: Nucleus . Cytoplasm . Localizes at both the nuclear and cytoplasmic site of the pores (PubMed:14963046). Shuttles between the nucleus and the cytoplasm (PubMed:14963046).
• Protein Description: Involved in the export of mRNA from the nucleus to the cytoplasm..
• Protein Sequence: MLRRKRERRNAVKENEMVIDTPLEKRRTPGKPRATREPPISVVITGHSKGSEDDLISFVWRKVKVRLMNISYSPASVTAVVKSQDFSRLNGLNGAAFAGDHLAIRRVDGASNVTQDYRKAKTKRSFRSVSAPSLSALATQAQRNVSKTLPQSTNETIEKLRQFLQTRYQPATKFLDLGNLQQDPLLKQMGILAEASTKSKMFPALMKVASLNFPDVISVSLSDNNLQSVTAVTTLAQTWPKLLNLSLANNRITSLSDLDPWSPKTKLPELQELVLVGNPIVTTFANRAMDYQREMVSRFPKLRLLDGNSINSEIIASQSTVPFPVYQSFFDKVETEQIVNSFLAAFFKGWDENRSALVNQLYSPNATFSISLNASNVRTNFSQKTDTKKWGAYKMKSRNLLYSQSQKESKSRLFNGHEEISNAVKSLPATAHDLSDRSQWVFDGWNLVLPSVGAAIKIVVHGQFEEPQNKRLLRSFDRTLLILPGGSTGILIINDLLVIRSFAGSLGWLPGQSSVRTSNNAMSASASKPSDIVQPRPEQAMLDTRQQIVLKIKAETGLNDYYAHMCCEQNNWDYNSALASFLELKSRNVIPAEAFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
128	Phosphorylation	KTKRSFRSVSAPSLS HCHHCHHCCCHHHHH	20.58	28889911
130	Phosphorylation	KRSFRSVSAPSLSAL HHCHHCCCHHHHHHH	35.39	28889911
133	Phosphorylation	FRSVSAPSLSALATQ HHCCCHHHHHHHHHH	34.37	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MEX67_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MEX67_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEX67_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELF1_SCHPO	elf1	genetic	12110682
RAE1_SCHPO	rae1	genetic	12110682
RAE1_SCHPO	rae1	genetic	11073978
NU184_SCHPO	nup184	genetic	11073978
NP106_SCHPO	npp106	genetic	11073978
RSM1_SCHPO	rsm1	genetic	15357289
RAE1_SCHPO	rae1	physical	11073978
MLO3_SCHPO	mlo3	physical	15990877
PST2_SCHPO	pst2	genetic	19547744
IPO11_HUMAN	IPO11	physical	21965294
IMPA1_HUMAN	IMPA1	physical	21965294

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128; SER-130 ANDSER-133, AND MASS SPECTROMETRY.
PubMed: 18257517