ELF1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ELF1_SCHPO
• UniProt AC: O14134
• Protein Name: mRNA export factor elf1
• Gene Name: elf1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1057
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Has a direct role in the mRNA export process. Appears to act within the rae1 mediated mRNA export pathway..
• Protein Sequence: MTSSVLIQGYEEDDVLKLLQELLDAETSQSCADVGKKIAQLFSNDNPLVTLKTTGFLDGLERAARNKKSGFHREAAMIGFATVIKNLGTPSEVVFLPYLPTILDSFSDRGEVVRQAAKMAAQALLDCLPAGAVETRLIPSLISYLDDSSIKWPSKVAALQLLGSLASSSPKAVADYMAALIPCIKERMHDTKPEISRAAITCMLNLCSVVENNDIIPHIPKLVDCMAHPETLEACIKDLSATTFVATVESVALAVLVPILKRALAQRSQSMLRLTVIITDNLCKLVPDPAEASDFLPELIPDVERIAQTAAMPEVRALASHALTTLNKAAAAQAAKAANNSEKQALDSACKELREAVLKNTSVPHELANSIIDYVCDALAALYKSNNFDKDKWTSQLGVLYLSPLVGEELASQISSKIYDDLHAFYKSLNSVDGISNLTIEEEELVNTDFSLAYGGRLLLSHTNLHLYRGHRYGVVGHNGCGKSTLLRAIGDYKVENFPSPDEVKTCFVAHSLQGEDTSMAILDFVAQDKALLTMNVTRQEAADALHSVGFTAEMQENPVASLSGGWKMKLELARAMLQKADILLLDEPTNHLDVANIAWLEAYLTSQKNITCLIVSHDSSFLDHVCTDIIHYEGVKNQAKKLGYYQGNLSAFVKVKPEAKSYYTLTATNEKFVFPPPGILTGVRSNTRLILKMTNASYTYPNAKKKSLDNVTVGLSLSSRVAILGPNGAGKSTLIKVLIGEVIPQEGKVFKHPNLRVGYVAQHAFHHLDQHLEKTPSQYIQWRYAGGQDREVSEKESRKLTEEDRAQLQRDITVNGERRRVEALIGRQKLKKSFQYEIKWFGKPHKYNTWVSREILLENGFQKFVQAFDDMESSREGLGFRELIPEDIRAHFEDVGLPGDIADYSPISSLSGGQKVKVVIAACLWNNPQLLVLDEPTNFLDRDALGGLAVAIRDWEGGVVMISHNEEFVSALCPEHWHVEAGKVTGKGKTAVDDGKFEDLSEKDLKKIEAKATKKKKLTRNEIKAKERRARERELAWLQSPKGTEKPKSFFSDDEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTSSVLIQG ------CCCCEEECC	40.80	29996109
3	Phosphorylation	-----MTSSVLIQGY -----CCCCEEECCC	30.24	29996109
4	Phosphorylation	----MTSSVLIQGYE ----CCCCEEECCCC	28.51	29996109
663	Phosphorylation	VKPEAKSYYTLTATN ECCCCCEEEEEEECC	10.36	25720772
708	Phosphorylation	YPNAKKKSLDNVTVG CCCCCCCCCCCEEEE	50.24	29996109
713	Phosphorylation	KKSLDNVTVGLSLSS CCCCCCEEEEEEHHC	18.34	29996109
717	Phosphorylation	DNVTVGLSLSSRVAI CCEEEEEEHHCCEEE	21.92	29996109
733	Phosphorylation	GPNGAGKSTLIKVLI CCCCCCHHHHHHHHH	27.77	28889911
834	Phosphorylation	GRQKLKKSFQYEIKW CHHHHHHHHCEEEEE	18.92	25720772
1002	Phosphorylation	DGKFEDLSEKDLKKI CCCCCCCCHHHHHHH	55.72	24763107
1041	Phosphorylation	RELAWLQSPKGTEKP HHHHHHHCCCCCCCC	26.80	28889911
1050	Phosphorylation	KGTEKPKSFFSDDEE CCCCCCCCCCCCCCC	39.80	28889911
1053	Phosphorylation	EKPKSFFSDDEE--- CCCCCCCCCCCC---	41.99	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ELF1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ELF1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ELF1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MEX67_SCHPO	mex67	genetic	12110682
RAE1_SCHPO	rae1	genetic	12110682
SEM1_SCHPO	rpn15	genetic	15990877
NP106_SCHPO	npp106	genetic	12110682
NU184_SCHPO	nup184	genetic	12110682

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-733; SER-1041 ANDSER-1053, AND MASS SPECTROMETRY.
PubMed: 18257517