dbPTM

NP106_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NP106_SCHPO
UniProt AC	O14310
Protein Name	Nucleoporin npp106
Gene Name	npp106
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	933
Subcellular Localization	Nucleus, nuclear pore complex .
Protein Description	Has a role in promoting mRNA export from the nucleus..
Protein Sequence	MESKEAKEKGVNTSDSKGSQIESSISDLREKSQHLFGVLLEPQVPVIQYGLNQLEEKARNLESKVLLTRDGDTKAHYLLAESGMNAEQTRQKIYSIHIHSPWDQLELDKKSLYEQPHTKLYNGQNVVASIENGYQSNVYEFQLRLMKNNGIAWENTKTEFMEDVGKLLHSKDNSGLGTSISMSLRPNLARPLLTASSVKSQSVRSLREVGSNLPIPTGSLTKIDGLNNQLSNDLTRSQTTNIFGFAEKASSFAAAVHKLNEARIRNQACHVWSLFASVSQMVNTEVIQLFDAWSLLAHMIDETRYGMGDFEARHLALDSSSAALAVEKNCIEGSLKYLENQFLSLIDLHLSDAGHITTVNSVEKVIAYSKLRFYKNGSWIKSTVSVVNDVPLWVVLFYLMRSGQLDAALQFVNTYSDDFEKLGRSFPLYFYSYAKNPSLPLPKQLRDRLQAEYGQLMKYAPEDPFKHAIYKLLGNCEPHRVSLPEVCVTSEDYMWIQLMFCRVNQNDVIDSNGGQSTNSLFNLYQLEKKIVAFGPRYFNPKNNTPTNYFLALLMCGEFERAISFLHTNYPVEATHFAVAMAYYGLLRTKNYEKNENILIYEADDVKINFPQLIIAYLKHLEYVDAAVYLDYIACIPLVPAYQACSINLTKILLLQSHEFSKFLGDIKPDTERTTGLLDLYLRLIPFDHDSLQKLYLEGAREADDDGRFGDSIILYHLLGDYDTVIGVAIKNLSQSIVSRGLWSIDSKESKNMHISSNVVASEAPDALAANLLAMYESNPKKSAKVSATNKKALKVLLKVVKVQKLYGQEKWDEVLQLIEHLDLLPINEVQAEFEPNEQIPPISARLRRRAFEFSTFQDEVLSVIPSLMYISMSSIKALYRTISKLPVVNEESKKKLQRLQFKGSMLVMFSTMIESRLSPQILEYLQAEQLTLL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	NTSDSKGSQIESSIS CCCCCCHHHCHHHHH	31.55	21712547
24	Phosphorylation	KGSQIESSISDLREK CHHHCHHHHHHHHHH	17.20	21712547
111	Phosphorylation	QLELDKKSLYEQPHT HHCCCHHHHHCCCCC	41.76	24763107
174	Phosphorylation	LLHSKDNSGLGTSIS HHCCCCCCCCCCCHH	45.59	29996109
178	Phosphorylation	KDNSGLGTSISMSLR CCCCCCCCCHHHHCC	28.12	29996109
179	Phosphorylation	DNSGLGTSISMSLRP CCCCCCCCHHHHCCC	15.74	25720772
200	Phosphorylation	LTASSVKSQSVRSLR HCHHHHCCHHHHHHH	26.07	24763107
202	Phosphorylation	ASSVKSQSVRSLREV HHHHCCHHHHHHHHH	26.96	21712547
205	Phosphorylation	VKSQSVRSLREVGSN HCCHHHHHHHHHCCC	29.62	21712547
211	Phosphorylation	RSLREVGSNLPIPTG HHHHHHCCCCCCCCC	40.13	21712547
217	Phosphorylation	GSNLPIPTGSLTKID CCCCCCCCCCCEEEC	39.87	28889911
219	Phosphorylation	NLPIPTGSLTKIDGL CCCCCCCCCEEECCC	35.03	28889911
221	Phosphorylation	PIPTGSLTKIDGLNN CCCCCCCEEECCCCC	27.87	28889911
237	Phosphorylation	LSNDLTRSQTTNIFG HCCCCCHHHHCCCHH	27.00	28889911
239	Phosphorylation	NDLTRSQTTNIFGFA CCCCHHHHCCCHHHH	24.05	25720772
240	Phosphorylation	DLTRSQTTNIFGFAE CCCHHHHCCCHHHHH	20.76	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NP106_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NP106_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NP106_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of NP106_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NP106_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-217; SER-219; THR-221AND SER-237, AND MASS SPECTROMETRY.	18257517 [Abstract]