IMPA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IMPA1_HUMAN
• UniProt AC: P29218
• Protein Name: Inositol monophosphatase 1
• Gene Name: IMPA1
• Organism: Homo sapiens (Human).
• Sequence Length: 277
• Subcellular Localization: Cytoplasm .
• Protein Description: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates..
• Protein Sequence: MADPWQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Acetylation	EVVCEAIKNEMNVML HHHHHHHHHHHHHCC	54.63	25953088
36	Ubiquitination	NEMNVMLKSSPVDLV HHHHHCCCCCCCCEE	30.69	21906983
37	Phosphorylation	EMNVMLKSSPVDLVT HHHHCCCCCCCCEEE	35.59	30266825
38	Phosphorylation	MNVMLKSSPVDLVTA HHHCCCCCCCCEEEC	27.62	30266825
44	Phosphorylation	SSPVDLVTATDQKVE CCCCCEEECCCHHHH	31.01	29396449
49	Acetylation	LVTATDQKVEKMLIS EEECCCHHHHHHHHH	55.99	23236377
49	Ubiquitination	LVTATDQKVEKMLIS EEECCCHHHHHHHHH	55.99	21906983
52	Ubiquitination	ATDQKVEKMLISSIK CCCHHHHHHHHHHHH	41.83	21890473
52	Ubiquitination	ATDQKVEKMLISSIK CCCHHHHHHHHHHHH	41.83	21890473
52	Acetylation	ATDQKVEKMLISSIK CCCHHHHHHHHHHHH	41.83	25953088
56	Phosphorylation	KVEKMLISSIKEKYP HHHHHHHHHHHHHCC	23.27	-
59	Ubiquitination	KMLISSIKEKYPSHS HHHHHHHHHHCCCCC	50.53	21890473
61	Ubiquitination	LISSIKEKYPSHSFI HHHHHHHHCCCCCCC	58.41	21906983
61	Acetylation	LISSIKEKYPSHSFI HHHHHHHHCCCCCCC	58.41	25038526
97	Phosphorylation	DPIDGTTNFVHRFPF ECCCCCCCCHHHCCE	36.46	27251275
111	Ubiquitination	FVAVSIGFAVNKKIE EEEEEEEEEECCCEE	6.99	21890473
131	Phosphorylation	SCVEGKMYTARKGKG EEECCEEEECCCCCC	10.75	-
137	Ubiquitination	MYTARKGKGAFCNGQ EEECCCCCCCCCCCC	50.53	-
145	Ubiquitination	GAFCNGQKLQVSQQE CCCCCCCEEEECCHH	42.14	-
156	Ubiquitination	SQQEDITKSLLVTEL CCHHHHHHHHHHHHC	39.17	21890473
157	Phosphorylation	QQEDITKSLLVTELG CHHHHHHHHHHHHCC	20.48	28060719
161	Phosphorylation	ITKSLLVTELGSSRT HHHHHHHHHCCCCCC	26.01	28450419
165	Phosphorylation	LLVTELGSSRTPETV HHHHHCCCCCCHHHH	29.30	25159151
166	Phosphorylation	LVTELGSSRTPETVR HHHHCCCCCCHHHHH	38.07	25159151
168	Phosphorylation	TELGSSRTPETVRMV HHCCCCCCHHHHHHH	27.68	25159151
171	Phosphorylation	GSSRTPETVRMVLSN CCCCCHHHHHHHHHC	18.02	28450419
177	Phosphorylation	ETVRMVLSNMEKLFC HHHHHHHHCHHHEEC	23.79	29978859
181	Acetylation	MVLSNMEKLFCIPVH HHHHCHHHEECEEEC	35.77	25953088
181	Ubiquitination	MVLSNMEKLFCIPVH HHHHCHHHEECEEEC	35.77	-
184	S-nitrosylation	SNMEKLFCIPVHGIR HCHHHEECEEECCCC	5.08	19483679
184	S-nitrosocysteine	SNMEKLFCIPVHGIR HCHHHEECEEECCCC	5.08	-
225	Phosphorylation	CWDVAGAGIIVTEAG EEECCCCEEEEEECC	14.83	27251275
227	Phosphorylation	DVAGAGIIVTEAGGV ECCCCEEEEEECCCE	2.83	24719451
264	Ubiquitination	ILAERIAKEIQVIPL HHHHHHHHHCCCEEC	53.64	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IMPA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IMPA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IMPA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IMPA1_HUMAN	IMPA1	physical	16189514
NXF1_HUMAN	NXF1	physical	21965294
IMPA1_HUMAN	IMPA1	physical	19447967
S100B_HUMAN	S100B	physical	19593677
IMPA1_HUMAN	IMPA1	physical	25416956
IMPA2_HUMAN	IMPA2	physical	25416956
GDIR1_HUMAN	ARHGDIA	physical	26344197
DUT_HUMAN	DUT	physical	26344197
IMPA2_HUMAN	IMPA2	physical	26344197
ISCU_HUMAN	ISCU	physical	26344197
PHP14_HUMAN	PHPT1	physical	26344197
RISC_HUMAN	SCPEP1	physical	26344197
THIO_HUMAN	TXN	physical	26344197
UGDH_HUMAN	UGDH	physical	26344197
IMPA1_HUMAN	IMPA1	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB01356: Lithium