ALP14_SCHPO - dbPTM
ALP14_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ALP14_SCHPO
UniProt AC O94534
Protein Name Spindle pole body component alp14
Gene Name alp14
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 809
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Chromosome, centromere, kinetochore. Kinetochore periphery. Spindle localization is alp7-dependent.
Protein Description Required for bipolar spindle formation and proper chromosome segregation. Has a role in connecting the kinetochores and the plus end of pole to chromosome microtubules. Also required for the activation of the spindle checkpoint pathway..
Protein Sequence MSQDQEEDYSKLPLESRIVHKVWKVRLSAYEECSKSFSLSADGSDNCFELWNNQSELWKSVLTDSNVAAQEAGTAAFVAYCRFSDPSHLLKAREISVLSISEKCLTSPRAGTRENALEALMLLVEADSAAPVIESIIPSLSARSPKVIASNVAAIASLVEQFGAKVIPSKMIIPHISNLFGHADKNVRKEASRLTVNIYRWTGDPLKDLLFKDLRPVQTKELESLFAELPTEPPKQTRFLKSQQPTSEPNVETQVEEQPALENEESEPEPSDDQFDLVEEVDVLPNVDPNLETLMASSKWKDRKEALDKLLPVLSQPKIKDNDFFNLVAILTKSVSKDANIMVVINAAHCIQAMAKGLRSNFSKYASTSINALLERSKEKKANVIESLSSAMDAVLATSSLDDLAELIASFAGNKNPQIKSSCFSLFSRSFSNMTSLPSKFTVDTCAKACVPGVSDTFEPVRSAAAEALGVLMKLVGERAINQYLSPLDDIRKSKIRSFYETATVKAKAPTKKSKVKPSKQEESKVVVPSNAKAVKKSVVPSSPVVPSPRKATNKSLSMDVSKGNAFENGPLLPRPTTRPVSRGLSRGTSSSLQQKVKASTPLNSGALNETVQNLKNMELDDPAPQPAKHSRVDRYEHPKVLEDNDSTISSLESLKRENEELREQLKVEHEENISMQKQLSELKGELNTLRSARKASPIGDRKPAFMRRANTDFLELSTSPSFQRSVREFEPTRPKLYSSIDVNQRSPLASAKTNGNFTFHAELPRSPFSSRANNINPDWTKAIDLAAKLKQKITEMKQTDQRHQGLIH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
538PhosphorylationNAKAVKKSVVPSSPV
CHHHHHHHCCCCCCC		23.7229996109
542PhosphorylationVKKSVVPSSPVVPSP
HHHHCCCCCCCCCCC		35.3524763107
543PhosphorylationKKSVVPSSPVVPSPR
HHHCCCCCCCCCCCC		18.6828889911
548PhosphorylationPSSPVVPSPRKATNK
CCCCCCCCCCCCCCC		26.2328889911
577PhosphorylationGPLLPRPTTRPVSRG
CCCCCCCCCCCCCCC		36.3929996109
578PhosphorylationPLLPRPTTRPVSRGL
CCCCCCCCCCCCCCC		35.3425720772
582PhosphorylationRPTTRPVSRGLSRGT
CCCCCCCCCCCCCCC		24.2625720772
601PhosphorylationQQKVKASTPLNSGAL
HHHHHCCCCCCHHHH		36.3329996109
647PhosphorylationKVLEDNDSTISSLES
CHHCCCCCCHHHHHH		33.6224763107
650PhosphorylationEDNDSTISSLESLKR
CCCCCCHHHHHHHHH		29.0325720772
651PhosphorylationDNDSTISSLESLKRE
CCCCCHHHHHHHHHH		32.1024763107
689PhosphorylationELKGELNTLRSARKA
HHHHHHHHHHHHHHC		35.8521712547
692PhosphorylationGELNTLRSARKASPI
HHHHHHHHHHHCCCC		35.2221712547
697PhosphorylationLRSARKASPIGDRKP
HHHHHHCCCCCCCCH		21.7828889911
712PhosphorylationAFMRRANTDFLELST
HHHHHCCCCCHHHCC		27.4325720772
718PhosphorylationNTDFLELSTSPSFQR
CCCCHHHCCCHHHHH		19.9125720772
719PhosphorylationTDFLELSTSPSFQRS
CCCHHHCCCHHHHHH		58.2325720772
720PhosphorylationDFLELSTSPSFQRSV
CCHHHCCCHHHHHHH		18.3828889911
722PhosphorylationLELSTSPSFQRSVRE
HHHCCCHHHHHHHHC		33.5029996109
739PhosphorylationPTRPKLYSSIDVNQR
CCCCHHCCCCCCCCC		31.1129996109
740PhosphorylationTRPKLYSSIDVNQRS
CCCHHCCCCCCCCCC		14.8429996109
747PhosphorylationSIDVNQRSPLASAKT
CCCCCCCCCCCCCCC		17.9424763107
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ALP14_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ALP14_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ALP14_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DIS1_SCHPOdis1genetic
11432827
TBB_SCHPOnda3genetic
11432827
TBA2_SCHPOatb2genetic
11432827
MAD2_SCHPOmad2genetic
11432827
DIS1_SCHPOdis1genetic
11369198
MIS12_SCHPOmis12genetic
11369198
DIS1_SCHPOdis1genetic
16920624
ALP7_SCHPOalp7physical
14742702
DIS1_SCHPOdis1genetic
12426374
KLP5_SCHPOklp5genetic
12426374
KLP6_SCHPOklp6genetic
12426374
ALP7_SCHPOalp7physical
19696784
RAF2_SCHPOraf2genetic
18818364
TIP1_SCHPOtip1physical
22696680
MAL3_SCHPOmal3physical
22696680
TBA1_SCHPOnda2physical
22696680
TBB_SCHPOnda3physical
22696680
TBA1_SCHPOnda2physical
26864000
ALP14_SCHPOalp14physical
26864000
ALP7_SCHPOalp7physical
26864000
TBA1A_HUMANTUBA1Aphysical
26864000
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ALP14_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-543; SER-548; SER-697AND SER-720, AND MASS SPECTROMETRY.

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