DIS1_SCHPO - dbPTM
DIS1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DIS1_SCHPO
UniProt AC Q09933
Protein Name Phosphoprotein p93
Gene Name dis1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 882
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body . Cytoplasm, cytoskeleton, spindle . Spindle pole body during metaphase and spindle microtubules during anaphase.
Protein Description Has a role in sister chromatid separation..
Protein Sequence MELDDFNSRILSQIFDKSWKVRFEAYESLLHALNRALDDSDVCFQPWIHDPALWKQGLCDSNVPTQEHAVKSLRCFLDKSRQKGVNSAKSFVVAPLLEKCLPSPRQSIRDASHQALLILAKSDALDYVLEGLFSAARVKHPKQAVASIKELNSLLENFGIPALSPIPFYKLIPTLFAQSDKNIRQEASNLSITLYAWVGNAFKTHVFPQLKQIQVSDLEASFQNVTSRTTTGGHISNSLNTQEVVLPSFSSNAKPKPHLSSKSSSQGNTLQRSTSSFSTPNRKVSQPSDFSASPSRSIVSPAKNIVGSTPVDVLSKLTPEFHTALSSPKWKDRKEALESMVPVCSNPVYQEGDYSELLRVIAKSLKDANVVVVGVAALLLTHIAKALRKGFLPYTGIVLPSLFDRFKERKSSLVHSLLDAANAIFESCGLNDIMDETLEFLKHKNPQVKTETLRWLNRCLQLTDVCPPRASLETLCSLCVTLINDTFEPVRMATTNVLATLVQIFSQPVLSKYIVGLDPKKLPKILELSKDITVNAHPNQPSRPRLPRVASPLKTSPVKLAVTPQAPSPLPSSNPSQASLTEESLSTRSSPTKPSTTSLRSQSLVNRFASSTLKAPSSSSKGVSNAASSKQSFPSSPSISKKLETSRLSTKKLPGSTMKAASALKEYPQQQSMKSGGEKQDNLVTITMSEKVELDLLREEKAIRQVQEAEDALERERLFREINDLQIQNAEMKEQVYEKESTISQKEVEITSLRNEKDRLSTRLQQVLLELEKQHETNEEAMDIDLKVPESGAIGRVTTRATATTAMDESGNAGMVSSGIHSVSTKPSSYGTRRSLAGSMLQKPTQFSRPSFMFSPEARDNWRESHDLSSHLWEQIQRMKKA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
275PhosphorylationNTLQRSTSSFSTPNR
CCCCCCCCCCCCCCC		30.5429996109
276PhosphorylationTLQRSTSSFSTPNRK
CCCCCCCCCCCCCCC		24.2529996109
278PhosphorylationQRSTSSFSTPNRKVS
CCCCCCCCCCCCCCC		44.9229996109
279PhosphorylationRSTSSFSTPNRKVSQ
CCCCCCCCCCCCCCC		23.6728889911
285PhosphorylationSTPNRKVSQPSDFSA
CCCCCCCCCCCCCCC		39.1329996109
288PhosphorylationNRKVSQPSDFSASPS
CCCCCCCCCCCCCCC		43.5824763107
291PhosphorylationVSQPSDFSASPSRSI
CCCCCCCCCCCCCCC		32.5921712547
293PhosphorylationQPSDFSASPSRSIVS
CCCCCCCCCCCCCCC		23.3928889911
295PhosphorylationSDFSASPSRSIVSPA
CCCCCCCCCCCCCCC		35.8421712547
297PhosphorylationFSASPSRSIVSPAKN
CCCCCCCCCCCCCCC		31.5121712547
300PhosphorylationSPSRSIVSPAKNIVG
CCCCCCCCCCCCCCC		19.9228889911
551PhosphorylationPRLPRVASPLKTSPV
CCCCCCCCCCCCCCC		28.1028889911
555PhosphorylationRVASPLKTSPVKLAV
CCCCCCCCCCCEEEE		46.0429996109
556PhosphorylationVASPLKTSPVKLAVT
CCCCCCCCCCEEEEC		26.5528889911
568PhosphorylationAVTPQAPSPLPSSNP
EECCCCCCCCCCCCH		41.9329996109
572PhosphorylationQAPSPLPSSNPSQAS
CCCCCCCCCCHHHCC		50.8929996109
573PhosphorylationAPSPLPSSNPSQASL
CCCCCCCCCHHHCCC		51.3129996109
576PhosphorylationPLPSSNPSQASLTEE
CCCCCCHHHCCCCHH		42.5021712547
579PhosphorylationSSNPSQASLTEESLS
CCCHHHCCCCHHHHC		28.3421712547
581PhosphorylationNPSQASLTEESLSTR
CHHHCCCCHHHHCCC		34.9027738172
584PhosphorylationQASLTEESLSTRSSP
HCCCCHHHHCCCCCC		22.7627738172
586PhosphorylationSLTEESLSTRSSPTK
CCCHHHHCCCCCCCC		30.9327738172
589PhosphorylationEESLSTRSSPTKPST
HHHHCCCCCCCCCCC		40.5329996109
590PhosphorylationESLSTRSSPTKPSTT
HHHCCCCCCCCCCCC		33.0428889911
592PhosphorylationLSTRSSPTKPSTTSL
HCCCCCCCCCCCCCH		58.4929996109
628PhosphorylationKGVSNAASSKQSFPS
CCCCCHHHCCCCCCC		35.3421712547
635PhosphorylationSSKQSFPSSPSISKK
HCCCCCCCCHHHHHH		53.5221712547
636PhosphorylationSKQSFPSSPSISKKL
CCCCCCCCHHHHHHH		23.9329996109
649PhosphorylationKLETSRLSTKKLPGS
HHCCCCCCCCCCCHH		36.7528889911
650PhosphorylationLETSRLSTKKLPGST
HCCCCCCCCCCCHHH		36.4728889911
672PhosphorylationKEYPQQQSMKSGGEK
HHCCHHHHCCCCCCC		24.6821712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
279TPhosphorylationKinaseCDK1P04551
GPS
293SPhosphorylationKinaseCDK1P04551
GPS
300SPhosphorylationKinaseCDK1P04551
GPS
551SPhosphorylationKinaseCDK1P04551
GPS
556SPhosphorylationKinaseCDK1P04551
GPS
590SPhosphorylationKinaseCDK1P04551
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DIS1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DIS1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DSK1_SCHPOdsk1genetic
8485317
KLP5_SCHPOklp5genetic
11870212
KLP6_SCHPOklp6genetic
11870212
MIS12_SCHPOmis12genetic
10398680
FLP1_SCHPOclp1genetic
15525536
FLP1_SCHPOclp1genetic
16085490
MSC1_SCHPOmsc1genetic
20858896
SWR1_SCHPOswr1genetic
20858896
ALP14_SCHPOalp14genetic
11432827
DIS3_SCHPOdis3genetic
1944266
PP11_SCHPOdis2genetic
1944266
NED1_SCHPOned1genetic
12376568
TBA1_SCHPOnda2physical
27872152
MAL3_SCHPOmal3physical
27872152
CND3_SCHPOcnd3genetic
25764183
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DIS1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293; SER-551; SER-556;SER-649 AND THR-650, AND MASS SPECTROMETRY.
"p93dis1, which is required for sister chromatid separation, is anovel microtubule and spindle pole body-associating proteinphosphorylated at the Cdc2 target sites.";
Nabeshima K., Kurooka H., Takeuchi M., Kinoshita K., Nakaseo Y.,Yanagida M.;
Genes Dev. 9:1572-1585(1995).
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, ANDPHOSPHORYLATION AT THR-279; SER-293; SER-300; SER-551; SER-556 ANDSER-590.

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