MSC1_SCHPO - dbPTM
MSC1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MSC1_SCHPO
UniProt AC Q9UT79
Protein Name Multicopy suppressor of chk1 protein 1
Gene Name msc1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1588
Subcellular Localization Nucleus . Associates with chromatin.
Protein Description Has a role in regulating chromatin structure via global deacetylation of histone H3. This function is associated with the activity of a histone deacetylase..
Protein Sequence MRKNSSHENQSSENIIEFPYVDFEELNVHSNIFSELEHAKPSTQQQQQQQNISNETTSTGPRICISRDEFKAVNLLTKEEINVRVTPKKEEFSRGLDFISDLYDQTARKSGAVRVIPPDNWKCPLTINTTTFKFLTRKNNPSSMSLVSNYPLDAISSQQKFHGNDKTLEKNSAKATINKSNSTAETSSTATVEPYDSNDLYRIFDRPDAVVLSYIFVLGKAVDLLQIKQWLQLSKQKNLLEFEFWSQAAQHYKLDVNSLRNAYNLYAETGVTTRTGNDGGSPINRPAKRVKRQNHIPKCKLCAQEGSSLVTCCICQSNYHYACVEAPFAPFSDIHYWTCNSCIPSSLKILWKEVDYHCISSFLQSSNELASSLKKQLPSFLAQTPLTLPSNTKTPPASARQSSRRTRSTSGKGFETKISINLDSDIKLLNTLSPLETFFWCCSFPSTASTSSPFSYYPESLPTPLLGRAVNTTAFPTSRQNAYYNDPWNLYFIHFSKLSPLRFTPPGILTSTISLGQPLTCQGWQRDSMSLFGMHYHHYGAQRIWYVIPEVDGPKYEKLLNDLSPSFIQEKPETLIKSKILLPISMLISNGIQVLTFVQNSNEFVITSPNTYYTVLDTGFSLSESVPFATKEWIQDMHAENSFNMYKNLHISAPFSLDHILLANATLDKTVHSAYWLMTCLKDRVDRELTLRNEFRKRHPLLTWIPTPLESSVMACAFCKTFAYLASIEEKNGTKTACLSHKDECFPNTDSDLTVLVRYDDNALLAAYSKVVERAHKADTWLENYKEALGSDNSRPSLKVLKTLLNEAETICCPLQEVSLVRNLVKTAQQWLDKFAIIFKKKSMVKKEKRKPKRGSATHSHLESPSEEVEDLNSSNINEADLLINLVEEAEQFTFDFPEMAVAFEKAESLKIFREKANAMKERSLSYEECLAIVEEGESLQLKTPELLYFKQYMEKTEWIDSFNQISQKTDSTMEELVELIERGEKIGLTSDNENMATALLLKEKSENWMKQVEGLLSQETLSTSKLFQLKSEANSICINRGLLEQLNEVLQKSENFHTQLVSLISRARDPDYYSRPTIEEAKTVLAESENLTNKPEEYTVAQKLLTQTYEWVRRGKRLFGKANAPLEIFNQHLEFVEQRNTNAMVDEGSDAPFHVGNEYYVIAGSDPSDFHYCFCRQPEAGMMIECELCHEWYHAKCMKMSKKKLRADEKFICPICDYRVEVPRHSHRPPLIELQKMVDDIPTLPFQPIEIELLKRVVKQAEEFKNKMQSEVCDPTQLSEKDVPLLQFYLRKLEGSEILFTEELNVFRQKLHEFMPVAPQPPPFIGESRSNRKPRPTKRQREIMEQVESGKLTSAEGAAAIAATQTRNQNNFISKPFNVHTLSTTLSPWAMKSLAQAAISPNPMPSAHDLLPTSNPAELFTNISPEIKELSVDSTSTLGGLNSSHLVSDQNASVICLCRQPFAISDGTVQCHNCLEWFHYECVGLSSDIVSTLSNYACPDCCSKEGKLYPWNTRPRSTPSVWLSQAYSPSVLQGTTENVAFLNKAFSASANLFDVLPVSNTPSHFSKMDYVLEDRKPDLFTETYLSM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
275PhosphorylationETGVTTRTGNDGGSP
HCCCCCCCCCCCCCC		37.9429996109
281PhosphorylationRTGNDGGSPINRPAK
CCCCCCCCCCCCCCH		28.3025720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MSC1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MSC1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MSC1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBC2_SCHPOrhp6physical
17456468
SWR1_SCHPOswr1physical
19910462
RUVB1_SCHPOrvb1physical
19910462
RUVB2_SCHPOrvb2physical
19910462
ACT_SCHPOact1physical
19910462
ARP4_SCHPOalp5physical
19910462
ARP6_SCHPOarp6physical
19910462
VPS72_SCHPOswc2physical
19910462
SWC4_SCHPOswc4physical
19910462
H2AZ_SCHPOpht1physical
19910462
MSC1_SCHPOmsc1physical
19911051
SWR1_SCHPOswr1physical
19911051
ARP4_SCHPOalp5physical
19911051
VPS72_SCHPOswc2physical
19911051
ARP6_SCHPOarp6physical
19911051
ACT_SCHPOact1physical
19911051
SWR1_SCHPOswr1physical
20858896
RUVB2_SCHPOrvb2physical
20858896
RUVB1_SCHPOrvb1physical
20858896
SWC4_SCHPOswc4physical
20858896
SSU72_SCHPOssu72genetic
18818364
CWC21_SCHPOcwf21genetic
18818364
SPC34_SCHPOspc34genetic
18818364
MCL1_SCHPOmcl1genetic
18818364
ASH2_SCHPOash2genetic
18818364
MED7_SCHPOmed7genetic
18818364
ELOC_SCHPOSPBC1861.07genetic
18818364
ASK1_SCHPOask1genetic
18818364
EST1_SCHPOest1genetic
18818364
YB3C_SCHPOcay1genetic
18818364
SWD3_SCHPOswd3genetic
18818364
YO48_SCHPOSPBC36B7.08cgenetic
18818364
CLR4_SCHPOclr4genetic
18818364
RSC1_SCHPOrsc1genetic
18818364
POB3_SCHPOpob3genetic
18818364
HPC2_SCHPOhip4genetic
18818364
HIF2_SCHPOhif2genetic
18818364
YQ9A_SCHPOSPCC18.10genetic
18818364
SDC1_SCHPOsdc1genetic
18818364
2AD1_SCHPOpar1genetic
18818364
BMT5_SCHPOSPCC1919.13cgenetic
18818364
SET1_SCHPOset1genetic
18818364
CCR4_SCHPOccr4genetic
18818364
ALP16_SCHPOalp16genetic
18818364
SKI2_SCHPOSPCC550.03cgenetic
18818364
SPP1_SCHPOspf1genetic
18818364
ALP14_SCHPOalp14genetic
18818364
ABP1_SCHPOcbp1genetic
18818364
H2AZ_SCHPOpht1genetic
18818364
SRB11_SCHPOsrb11genetic
18818364
VPS71_SCHPOvps71genetic
18818364
PLMT_SCHPOcho1genetic
18818364
AIR1_SCHPOair1genetic
18818364
ARP6_SCHPOarp6genetic
18818364
SWC5_SCHPOswc5genetic
18818364
COX19_SCHPOSPCC1672.04cgenetic
22681890
MEI2_SCHPOmei2genetic
22681890
SWR1_SCHPOswr1genetic
22681890
ERI1_SCHPOeri1genetic
22681890
ALP16_SCHPOalp16genetic
22681890
IMA3_SCHPOSPCC550.11genetic
22681890
SWD3_SCHPOswd3genetic
22681890
YAC5_SCHPOcph1genetic
22681890
GGT2_SCHPOggt2genetic
22681890
MU147_SCHPOmug147genetic
22681890
FEP1_SCHPOfep1genetic
22681890
YK82_SCHPObdf2genetic
22681890
CLR4_SCHPOclr4genetic
22681890
DAD1_SCHPOdad1genetic
22681890
SNF5_SCHPOsnf5genetic
22681890
ZIP1_SCHPOzip1genetic
22681890
ZRG17_SCHPOzrg17genetic
22681890
POM1_SCHPOpom1genetic
22681890
ARP42_SCHPOarp42genetic
22681890
SWC3_SCHPOswc3genetic
22681890
PHD1_SCHPOhos2genetic
22681890
SET3_SCHPOset3genetic
22681890
BCA1_SCHPOeca39genetic
22681890
YBPC_SCHPOSPBC16H5.12cgenetic
22681890
ASH2_SCHPOash2genetic
22681890
MMS19_SCHPOmms19genetic
22681890
YO48_SCHPOSPBC36B7.08cgenetic
22681890
PPIB_SCHPOcyp4genetic
22681890
YCPF_SCHPOSPCC663.15cgenetic
22681890
ATP5E_SCHPOatp15genetic
22681890
YB35_SCHPOSPBC2F12.05cgenetic
22681890
YCF8_SCHPOSPCC1393.08genetic
22681890
YCTB_SCHPOent3genetic
22681890
VPS72_SCHPOswc2genetic
22681890
TGCE3_SCHPOSPBC14C8.15genetic
22681890
SET1_SCHPOset1genetic
22681890
MDE6_SCHPOmde6genetic
22681890
MCP2_SCHPOmcp2genetic
22681890
ASK1_SCHPOask1genetic
22681890
TOM70_SCHPOtom70genetic
22681890
YQ9A_SCHPOSPCC18.10genetic
22681890
FFT3_SCHPOfft3genetic
22681890
DAD2_SCHPOdad2genetic
22681890
SDE2_SCHPOsde2genetic
22681890
H2AZ_SCHPOpht1genetic
22681890
CGM2_SCHPOmcs2genetic
22681890
MID1_SCHPOmid1genetic
22681890
KPR1_SCHPOSPAC4A8.14genetic
22681890
PVH1_SCHPOSPBC17A3.06genetic
22681890
EMC1_SCHPOemc1genetic
22681890
PRZ1_SCHPOprz1genetic
22681890
RHP23_SCHPOrhp23genetic
22681890
ESA1_SCHPOmst1physical
23695164
COQ2_SCHPOppt1physical
26771498
ESA1_SCHPOmst1physical
26771498
MRC1_SCHPOmrc1physical
26771498
YK01_SCHPOSPAP11E10.01physical
26771498
YKW2_SCHPOSPAP32A8.02physical
26771498
PMT4_SCHPOogm4physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MSC1_SCHPO

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Related Literatures of Post-Translational Modification

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