dbPTM

YB35_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YB35_SCHPO
UniProt AC	O14340
Protein Name	Oxysterol-binding protein homolog C2F12.05c
Gene Name	SPBC2F12.05c
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	1310
Subcellular Localization
Protein Description
Protein Sequence	MEHPSPDSVSSTSSSDHKKAELSDSLKQLQLLQAFQAGDIKQVDNLLHNKSKDECTHALFISIQCANVQMVKHILSVFDVDVNAYDKNKNTPLHLAAMAGRQDIVEALLLHPDINYNLVNANNKKAYQVATSPQLMDFMKGFYVTYTKETAREFKKAFKERNLESMDYLMRHNEFNDAIDLNEVDIKTGQTYLHVATKAKDAELVKWLLDNGADPYRRDKFGKLPTDYTKDENMRSLLRSYSGNRDSSSAPAVPQHMSGYLKKWTNYKSGYKLRWFTLNNGVLSYYKNQDDASSACRGSINLKLARLVHDPKQPTVFQVIGKGSVRYSVKANSPVEAKKWIAAISSAIENDEEANKPNVTADNASFGTHDLAPAAHKFTQSNASGNSGWDDNESDIDRAQLPSRENFEFNVNIAKLQVETLHKLIDSAMQTEKVKKDPSLSQVFDGISNSFNTLHKTVLEMLDLQRQAEHYYKRKLDNAKAINALWAENLKTVVEEQDQIEERYHRSEAHRRRTKRAFRRLAASLKKRPSDKDNKLHIHYDDGAMSSTSYSTDFTDDEEETNTKDEFFDVDAHDNNHANKAEPSQTANNVHEIREPSFSSEHKPQPSLKTTTDVSSPETKQNIADIRKTTLTDQTEEFTERRDNNGSIPSKQPSDEQHLGKESLPSQQSTVSNHHRKESIPSKQPTEGQHARQESLPSQQTTETKHLRKESTPSKQPTEGQHTRQESLPSQQTTETKHLRKESIPSKQPTEGQHARQESLPSQQTTETKHLRKESIPSKQPSGGQQLRQESLPSQQSSESKQSTQHQQPVEVQKSIQSDVSAPKAKEVSEKPVSHQAKPSNASQLSRNTDDTQAKEAPKEASIPDNASTASTKVSNDSHLKPDADKKSVSSELTHASKPSLDEKTMQLAKQIAVSFHGYEAPTRENLDVNDDRPKISLWGILKGMIGKDMTKMTLPVSFNEPTSLLQRVAEDMEYTELLDQASHNKDPYQRILYVAAFAASEYASTLNRVAKPFNPLLGETYEFCHPQRGFRFIVEQVSHHPPVGAAYSESANWKYYGESSVKSKFYGKSFDISPLGTWFLELRHPSGEVELYTWKKVTSSVVGIILGSPSVDNYGQMHIVNHSSGINCVLDFKPRGWRGTNAHEVKGSVQSTDDTPKWMVNGHWNDKIFGQQPNGNKILLWQNHERPPRPFNLTPFAISLNALTPQLKPWLPPTDTRLRPDQRAMENGQYDLAASEKNRLEEKQRKKRRMREQGEMPPWSPRWFSAAKHPVTGEDYWQFNNEYWKIREEAGEAHLAGKEFEWPNVDDIF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEHPSPDSVSST ---CCCCCCCCCCCC	43.16	21712547
8	Phosphorylation	MEHPSPDSVSSTSSS CCCCCCCCCCCCCCC	27.55	21712547
10	Phosphorylation	HPSPDSVSSTSSSDH CCCCCCCCCCCCCHH	31.67	21712547
11	Phosphorylation	PSPDSVSSTSSSDHK CCCCCCCCCCCCHHH	30.10	24763107
12	Phosphorylation	SPDSVSSTSSSDHKK CCCCCCCCCCCHHHH	25.73	24763107
13	Phosphorylation	PDSVSSTSSSDHKKA CCCCCCCCCCHHHHH	29.77	29996109
14	Phosphorylation	DSVSSTSSSDHKKAE CCCCCCCCCHHHHHH	39.61	29996109
15	Phosphorylation	SVSSTSSSDHKKAEL CCCCCCCCHHHHHHH	43.43	21712547
360	Phosphorylation	EANKPNVTADNASFG HHCCCCCCCCCCCCC	34.63	21712547
365	Phosphorylation	NVTADNASFGTHDLA CCCCCCCCCCCCCCH	30.39	21712547
368	Phosphorylation	ADNASFGTHDLAPAA CCCCCCCCCCCHHHH	15.37	21712547
381	Phosphorylation	AAHKFTQSNASGNSG HHHHHCCCCCCCCCC	31.16	28889911
384	Phosphorylation	KFTQSNASGNSGWDD HHCCCCCCCCCCCCC	42.64	28889911
387	Phosphorylation	QSNASGNSGWDDNES CCCCCCCCCCCCCHH	44.80	28889911
394	Phosphorylation	SGWDDNESDIDRAQL CCCCCCHHHCCHHHC	46.23	28889911
597	Phosphorylation	VHEIREPSFSSEHKP HHHCCCCCCCCCCCC	32.76	28889911
599	Phosphorylation	EIREPSFSSEHKPQP HCCCCCCCCCCCCCC	38.87	21712547
600	Phosphorylation	IREPSFSSEHKPQPS CCCCCCCCCCCCCCC	41.53	21712547
616	Phosphorylation	KTTTDVSSPETKQNI CCCCCCCCHHHHHCH	26.97	27738172
672	Phosphorylation	PSQQSTVSNHHRKES CCCCCHHCCCCCCCC	30.45	24763107
679	Phosphorylation	SNHHRKESIPSKQPT CCCCCCCCCCCCCCC	42.72	28889911
682	Phosphorylation	HRKESIPSKQPTEGQ CCCCCCCCCCCCCCC	42.10	29996109
686	Phosphorylation	SIPSKQPTEGQHARQ CCCCCCCCCCCHHCH	50.70	21712547
695	Phosphorylation	GQHARQESLPSQQTT CCHHCHHCCCCCCCC	36.92	28889911
698	Phosphorylation	ARQESLPSQQTTETK HCHHCCCCCCCCCCH	39.97	21712547
711	Phosphorylation	TKHLRKESTPSKQPT CHHHHCCCCCCCCCC	48.96	24763107
712	Phosphorylation	KHLRKESTPSKQPTE HHHHCCCCCCCCCCC	32.45	21712547
714	Phosphorylation	LRKESTPSKQPTEGQ HHCCCCCCCCCCCCC	43.97	24763107
723	Phosphorylation	QPTEGQHTRQESLPS CCCCCCCCCHHCCCC	26.59	21712547
727	Phosphorylation	GQHTRQESLPSQQTT CCCCCHHCCCCCCCC	36.92	25720772
743	Phosphorylation	TKHLRKESIPSKQPT CHHHHHHCCCCCCCC	42.72	28889911
746	Phosphorylation	LRKESIPSKQPTEGQ HHHHCCCCCCCCCCC	42.10	25720772
750	Phosphorylation	SIPSKQPTEGQHARQ CCCCCCCCCCCHHCH	50.70	21712547
759	Phosphorylation	GQHARQESLPSQQTT CCHHCHHCCCCCCCC	36.92	28889911
762	Phosphorylation	ARQESLPSQQTTETK HCHHCCCCCCCCCCH	39.97	21712547
775	Phosphorylation	TKHLRKESIPSKQPS CHHHHHHCCCCCCCC	42.72	19547744
778	Phosphorylation	LRKESIPSKQPSGGQ HHHHCCCCCCCCCHH	42.10	29996109
791	Phosphorylation	GQQLRQESLPSQQSS HHHHHHHCCCCCCCC	36.92	21712547
797	Phosphorylation	ESLPSQQSSESKQST HCCCCCCCCCHHCCC	28.56	25720772
829	Phosphorylation	APKAKEVSEKPVSHQ CCCCCCCCCCCCCCC	40.78	29996109
834	Phosphorylation	EVSEKPVSHQAKPSN CCCCCCCCCCCCCCC	20.57	21712547
840	Phosphorylation	VSHQAKPSNASQLSR CCCCCCCCCHHHHHC	44.30	24763107
843	Phosphorylation	QAKPSNASQLSRNTD CCCCCCHHHHHCCCC	35.59	24763107
846	Phosphorylation	PSNASQLSRNTDDTQ CCCHHHHHCCCCCHH	18.82	21712547
849	Phosphorylation	ASQLSRNTDDTQAKE HHHHHCCCCCHHHHH	33.86	21712547
852	Phosphorylation	LSRNTDDTQAKEAPK HHCCCCCHHHHHCCC	32.98	21712547
862	Phosphorylation	KEAPKEASIPDNAST HHCCCCCCCCCCCCC	35.43	29996109
868	Phosphorylation	ASIPDNASTASTKVS CCCCCCCCCCCCCCC	30.66	24763107
869	Phosphorylation	SIPDNASTASTKVSN CCCCCCCCCCCCCCC	23.40	24763107
871	Phosphorylation	PDNASTASTKVSNDS CCCCCCCCCCCCCCC	28.93	21712547
872	Phosphorylation	DNASTASTKVSNDSH CCCCCCCCCCCCCCC	32.76	28889911
875	Phosphorylation	STASTKVSNDSHLKP CCCCCCCCCCCCCCC	36.15	24763107
878	Phosphorylation	STKVSNDSHLKPDAD CCCCCCCCCCCCCCC	34.66	24763107
888	Phosphorylation	KPDADKKSVSSELTH CCCCCCCCHHHHHHH	32.73	25720772
890	Phosphorylation	DADKKSVSSELTHAS CCCCCCHHHHHHHCC	25.78	24763107
891	Phosphorylation	ADKKSVSSELTHASK CCCCCHHHHHHHCCC	34.17	24763107
894	Phosphorylation	KSVSSELTHASKPSL CCHHHHHHHCCCCCC	16.02	24763107
897	Phosphorylation	SSELTHASKPSLDEK HHHHHHCCCCCCCHH	37.18	28889911
900	Phosphorylation	LTHASKPSLDEKTMQ HHHCCCCCCCHHHHH	52.79	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of YB35_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YB35_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YB35_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of YB35_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YB35_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-384 AND SER-394, ANDMASS SPECTROMETRY.	18257517 [Abstract]