EMC1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EMC1_SCHPO
• UniProt AC: O13981
• Protein Name: ER membrane protein complex subunit 1
• Gene Name: emc1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 885
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
• Protein Description: The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER)..
• Protein Sequence: MLRPLWPLFLTALFLNIYRAASVLIDEAGKNDFEISLLGKVNDLVYDTKNEYLYAVSQKGLLAKLNASNGDVIWRQSIAPETSQLNYNPVTNFIITVDKDYLYIWNSKNGILDRKIELADGKGKLFEVNKGFVYLNPHTRKFIELDLQASFSISIERDLQLDAISFLTYAEKNYVLFKRDGQFVLQALDHNYAVYGPETVLNVPENAQLLVTEKDVIIYSSNGVIYGIHVSMADISQLLIDEYKTFEWSSIPGKRHGYSITVDSQSTPVTYLFVIIDSEFVLIDEYIHEDTEALGYIHMEDNQTFSRVFAVANQIKFAPATVITIPNQLSRPVFRLFTFAEGEISAIVILDDGTFFSFSNTELVWKREEALAYAINPSILPTTLLTSYQKSIQDEENSSVSFLNRWYRHFNQLIDFLKHPHGFTSSSVLDDAFTTKIIIPTSTGSIFCLSSDPKQVHRILWRYDFNINPESVESWLLDISDEDPKFAFVHQWNDAFSFYILNASDGSVISQKSRDFKADEFYYVDNISKNLPNQIFAVKDYKVLPLTGDNSIFEKISQEANSIFVYTSETKVEGFSISADLTMDVQWSYNLAEGEIVIASIRRNPHEIVASFGRVLQNREVMYKYLNPNLFALFSKCKNDLVVYVMDSVTGSIVYQNKHQGIILFDKVYGVFSENWLVYSYQSDVPNLSTKIISVELFEGSHSNEKIDSNEIYSRHNDYRPYAFTKAYIFDREITTLGVTNTPQGITSRDVLLGLSSNQVAMIPQALLSPMRPVLRPNEKANDASFIPYEPIIPLNDDMVLSYNKRVYGVSQITSGITNFESTTLVLSTGLDVFFTRTAPSMPYDMLSSHFDKKQLMLTTFGILLAVLLTKPLVKKKQLNTKWYN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	N-linked_Glycosylation	KGLLAKLNASNGDVI HCHHHHHCCCCCCEE	40.39	-
302	N-linked_Glycosylation	GYIHMEDNQTFSRVF EEEEECCCCEEHHHH	29.50	-
397	N-linked_Glycosylation	KSIQDEENSSVSFLN HHCCCCCCCCHHHHH	37.22	-
502	N-linked_Glycosylation	AFSFYILNASDGSVI CEEEEEEECCCCCEE	28.04	-
526	N-linked_Glycosylation	DEFYYVDNISKNLPN CEEEEEECCCCCCCC	30.32	-
687	N-linked_Glycosylation	SYQSDVPNLSTKIIS EEECCCCCCCCEEEE	46.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EMC1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EMC1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EMC1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of EMC1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.