RUVB2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RUVB2_SCHPO
• UniProt AC: O94692
• Protein Name: RuvB-like helicase 2
• Gene Name: rvb2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 465
• Subcellular Localization: Nucleus.
• Protein Description: DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity)..
• Protein Sequence: MSISVTSHNDVSKLERIGAHSHIKGIGLNDNLEPKESSQGMVGQVKARRAAGVILKMIQEGRIAGRAILMAGPPSTGKTAIAMGMAQSLGSDTPFVTLSASEVYSLEMSKTEALLQALRKSIGVRIKEETEIIEGEVVEVQIDRSITGGNKQGKLTIRSTDMETVYDLGTKMIDSLTKEKVLAGDVISIDKSVGRVTKLGRSFSRARDYDAMGADTRFVQCPQGEIQKRKEVVHTVSLHDIDVINSRTQGFLALFSGDTGEIKPEVREQINTKVSEWREEGKAEIVPGVLFVDEVHMLDIECFSFFNRALEDDLAPIVIMASNRGITRIRGTNYRSPHGIPVDLLDRMLIISTLPYSHEEVKEILKIRCQEEDVDMEPSALDYLSTIGQETSLRYALLLISSSNQVALKRKSATIEESDIRRVYELFLDQKRSVEYLEEYGKNYITENEWSASGAQDNAVAMQED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSISVTSHN ------CCEECCCCC	24.46	24763107
4	Phosphorylation	----MSISVTSHNDV ----CCEECCCCCCH	16.43	21712547
6	Phosphorylation	--MSISVTSHNDVSK --CCEECCCCCCHHH	19.92	29996109
7	Phosphorylation	-MSISVTSHNDVSKL -CCEECCCCCCHHHH	20.38	24763107
412	Phosphorylation	QVALKRKSATIEESD CEEEHHHCCCCCHHH	34.38	25720772
414	Phosphorylation	ALKRKSATIEESDIR EEHHHCCCCCHHHHH	35.69	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RUVB2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RUVB2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RUVB2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD22_SCHPO	rad52	physical	23779158

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.