dbPTM

PLMT_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PLMT_SCHPO
UniProt AC	O74827
Protein Name	Phosphatidyl-N-methylethanolamine N-methyltransferase {ECO:0000255\|HAMAP-Rule:MF_03216, ECO:0000305}
Gene Name	cho1 {ECO:0000303\|PubMed:9755189}
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	221
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein . Mitochondrion membrane Multi-pass membrane protein .
Protein Description	Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC)..
Protein Sequence	MSLILYPKPTSYLYQPFIKAYFSLNMAIFEINNSFLICAVSIALNPLLWNIAARSEYNHKTLTKLANGDSKKACYMLAACIFVAGIVRDLIYQNALKQQPTLGIFMNPLVQGIAKLIFCFGSVLVLSSMYKLGLVGTYLGDYFGFLLPERVSGFPFNVNDNPMYNGSTLCFLSTALRYGKVAGLLLTLEVFFVYRIALKFEEPFTAKIYAARDSKQAKKSE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of PLMT_SCHPO !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PLMT_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PLMT_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PLMT_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAN3_SCHPO	ppk26	genetic	18931302
SHK2_SCHPO	shk2	genetic	18931302
VPS8_SCHPO	vps8	genetic	18931302
CUL3_SCHPO	cul3	genetic	18931302
RYH1_SCHPO	ryh1	genetic	18931302
RT109_SCHPO	rtt109	genetic	18818364
SUM2_SCHPO	sum2	genetic	18818364
HEL2_SCHPO	SPCC1223.01	genetic	18818364
RPA12_SCHPO	rpa12	genetic	18818364
HST2_SCHPO	hst2	genetic	18818364
BDF1_SCHPO	bdf1	genetic	18818364
CAF1_SCHPO	caf1	genetic	18818364
AAKB_SCHPO	amk2	genetic	18818364
NUP60_SCHPO	nup60	genetic	18818364
CCR4_SCHPO	ccr4	genetic	18818364
MU154_SCHPO	mug154	genetic	18818364
NOT2_SCHPO	not2	genetic	18818364
SKI2_SCHPO	SPCC550.03c	genetic	18818364
AGO1_SCHPO	ago1	genetic	18818364
POB3_SCHPO	pob3	genetic	18818364
UBP3_SCHPO	ubp3	genetic	18818364
SPT2_SCHPO	spt2	genetic	18818364
SET1_SCHPO	set1	genetic	18818364
H2A1_SCHPO	hta1	genetic	18818364
YOI5_SCHPO	SPBC1778.05c	genetic	22681890
YIP4_SCHPO	SPAC644.13c	genetic	22681890
SNF5_SCHPO	snf5	genetic	22681890
RICTR_SCHPO	ste20	genetic	22681890
ARP42_SCHPO	arp42	genetic	22681890
ATP14_SCHPO	atp14	genetic	22681890
SET1_SCHPO	set1	genetic	22681890
FFT3_SCHPO	fft3	genetic	22681890
IVN1_SCHPO	ivn1	genetic	22681890
YA99_SCHPO	SPAC13G6.09	genetic	22681890
RL9A_SCHPO	rpl901	genetic	22681890
EMC1_SCHPO	emc1	genetic	22681890
PRZ1_SCHPO	prz1	genetic	22681890
YHM9_SCHPO	SPBC1271.09	genetic	22681890

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PLMT_SCHPO

Related Literatures of Post-Translational Modification