NUP60_SCHPO - dbPTM
NUP60_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NUP60_SCHPO
UniProt AC O74500
Protein Name Nucleoporin nup60
Gene Name nup60
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 736
Subcellular Localization Nucleus, nuclear pore complex. Nucleus membrane
Peripheral membrane protein
Nucleoplasmic side.
Protein Description Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (By similarity)..
Protein Sequence MSSGPIRTLHKGKAARNRTPYDRIAASKDGNHSNGPQTPSKSIFQRAKEWLTPSSWKKAISIFSSPVVNKHEDSFDSKTDEEYLQNVSTTTEDVSMLINTPVTEKYEQEHRDTSAQATPSIVEQSPNQMLANFFSKKGKTPLNEIEKEGIISILNKSASPSSSVISPAASLNRFQTPRAAAISKRESGVSSEPRARTSSLTPGNTPNSAKQWSAFRSTFSPLREQDQLSTISPNSLLPAQRLSYYGPTLSTPYNRRLRHKRHSTTPISLSNSIAPSLSFQPKKARYESANVSFNDTSFTNVPTSSPLHQSTTANHPEKTPSRAAASLLSILDSKEKNTPSITAKAGSPQSAPSKASYISPYARPGITTSRRRHDQIRPSSEKSEPEKKEPSAFETLEKSSNVQTYKPSLMPEFLEKASTHGSFAKQKEGEQTSLSEKTALSEPENKTPVFSFKAPSATTDKPSPPVSSIFSFNAPSAASTKPSPAVSSTFSFNAPTTTPSATSFSIINKEKPARSPNETIDVDLEEEGSGISAEVEVANEGEDLQKNATEVKASTSEKPVFRFEAVTDEKNSEVSSSNQASSSTMISQPNTGFSFGSFNKPAGQEEKPQQRSLFSASFTTQKPELPAAKIEPEVQMTNVAIDQRSFEQAEKSPISVSESTSLVEVEKPSAEGTNEHKQDATMTLEKTDKQGSLEEEPFPKFSFTVLPKENGENLSTMESTQELPKFSFSVLKEEKN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MSSGPIRTLH
-----CCCCCCCCCC		47.4924763107
33PhosphorylationASKDGNHSNGPQTPS
CCCCCCCCCCCCCCC		47.7021712547
38PhosphorylationNHSNGPQTPSKSIFQ
CCCCCCCCCCHHHHH		32.4424763107
40PhosphorylationSNGPQTPSKSIFQRA
CCCCCCCCHHHHHHH		42.2828889911
52PhosphorylationQRAKEWLTPSSWKKA
HHHHHHCCHHHHHHH		23.3824763107
54PhosphorylationAKEWLTPSSWKKAIS
HHHHCCHHHHHHHHH		43.5321712547
55PhosphorylationKEWLTPSSWKKAISI
HHHCCHHHHHHHHHH		44.0824763107
61PhosphorylationSSWKKAISIFSSPVV
HHHHHHHHHHCCCCC		23.5721712547
64PhosphorylationKKAISIFSSPVVNKH
HHHHHHHCCCCCCCC		31.8721712547
65PhosphorylationKAISIFSSPVVNKHE
HHHHHHCCCCCCCCC		15.8025720772
74PhosphorylationVVNKHEDSFDSKTDE
CCCCCCCCCCCCCCH		28.1524763107
77PhosphorylationKHEDSFDSKTDEEYL
CCCCCCCCCCCHHHH		35.1324763107
88PhosphorylationEEYLQNVSTTTEDVS
HHHHHHCCCCHHHHH		27.8229996109
95PhosphorylationSTTTEDVSMLINTPV
CCCHHHHHHHHCCCC		21.8629996109
106PhosphorylationNTPVTEKYEQEHRDT
CCCCCHHHHHHCCCC		19.3321712547
113PhosphorylationYEQEHRDTSAQATPS
HHHHCCCCCCCCCHH		26.3924763107
114PhosphorylationEQEHRDTSAQATPSI
HHHCCCCCCCCCHHH		23.7521712547
118PhosphorylationRDTSAQATPSIVEQS
CCCCCCCCHHHHHCC		12.8924763107
120PhosphorylationTSAQATPSIVEQSPN
CCCCCCHHHHHCCHH		34.6121712547
125PhosphorylationTPSIVEQSPNQMLAN
CHHHHHCCHHHHHHH		16.5925720772
135PhosphorylationQMLANFFSKKGKTPL
HHHHHHHHCCCCCCH		29.3529996109
140PhosphorylationFFSKKGKTPLNEIEK
HHHCCCCCCHHHHHH		41.5024763107
157PhosphorylationIISILNKSASPSSSV
HHHHHCCCCCCCCCC		32.6728889911
159PhosphorylationSILNKSASPSSSVIS
HHHCCCCCCCCCCCC		32.1928889911
161PhosphorylationLNKSASPSSSVISPA
HCCCCCCCCCCCCCH		32.5228889911
162PhosphorylationNKSASPSSSVISPAA
CCCCCCCCCCCCCHH		31.8228889911
163PhosphorylationKSASPSSSVISPAAS
CCCCCCCCCCCCHHH		28.0125720772
166PhosphorylationSPSSSVISPAASLNR
CCCCCCCCCHHHCCC		13.3128889911
170PhosphorylationSVISPAASLNRFQTP
CCCCCHHHCCCCCCC		28.4321712547
176PhosphorylationASLNRFQTPRAAAIS
HHCCCCCCCHHHHHH		16.4221712547
187PhosphorylationAAISKRESGVSSEPR
HHHHHCCCCCCCCCC		48.8321712547
191PhosphorylationKRESGVSSEPRARTS
HCCCCCCCCCCCCCC		49.5727738172
197PhosphorylationSSEPRARTSSLTPGN
CCCCCCCCCCCCCCC		22.9825720772
198PhosphorylationSEPRARTSSLTPGNT
CCCCCCCCCCCCCCC		20.1429996109
199PhosphorylationEPRARTSSLTPGNTP
CCCCCCCCCCCCCCC		35.3329996109
201PhosphorylationRARTSSLTPGNTPNS
CCCCCCCCCCCCCCC		30.9725720772
205PhosphorylationSSLTPGNTPNSAKQW
CCCCCCCCCCCHHHH		29.7525720772
217PhosphorylationKQWSAFRSTFSPLRE
HHHHHHHHCCCCCCH		27.6125720772
218PhosphorylationQWSAFRSTFSPLREQ
HHHHHHHCCCCCCHH		24.7129996109
220PhosphorylationSAFRSTFSPLREQDQ
HHHHHCCCCCCHHHH		24.1025720772
229PhosphorylationLREQDQLSTISPNSL
CCHHHHHCCCCHHHC		20.3329996109
230PhosphorylationREQDQLSTISPNSLL
CHHHHHCCCCHHHCC		33.7825720772
232PhosphorylationQDQLSTISPNSLLPA
HHHHCCCCHHHCCCC		20.3725720772
235PhosphorylationLSTISPNSLLPAQRL
HCCCCHHHCCCCCHH		34.3729996109
243PhosphorylationLLPAQRLSYYGPTLS
CCCCCHHHHCCCCCC		20.6329996109
244PhosphorylationLPAQRLSYYGPTLST
CCCCHHHHCCCCCCC		19.6229996109
250PhosphorylationSYYGPTLSTPYNRRL
HHCCCCCCCCCHHCC		29.7929996109
251PhosphorylationYYGPTLSTPYNRRLR
HCCCCCCCCCHHCCC		32.6729996109
253PhosphorylationGPTLSTPYNRRLRHK
CCCCCCCCHHCCCCC		22.7629996109
263PhosphorylationRLRHKRHSTTPISLS
CCCCCCCCCCCCCCC		37.7024763107
264PhosphorylationLRHKRHSTTPISLSN
CCCCCCCCCCCCCCC		30.3921712547
265PhosphorylationRHKRHSTTPISLSNS
CCCCCCCCCCCCCCC		22.9524763107
268PhosphorylationRHSTTPISLSNSIAP
CCCCCCCCCCCCCCC		27.2724763107
270PhosphorylationSTTPISLSNSIAPSL
CCCCCCCCCCCCCCC		23.0321712547
272PhosphorylationTPISLSNSIAPSLSF
CCCCCCCCCCCCCCC		19.4221712547
276PhosphorylationLSNSIAPSLSFQPKK
CCCCCCCCCCCCCCC		27.8521712547
278PhosphorylationNSIAPSLSFQPKKAR
CCCCCCCCCCCCCCC		26.6021712547
292PhosphorylationRYESANVSFNDTSFT
CCEECCCCCCCCCCC		20.3821712547
296PhosphorylationANVSFNDTSFTNVPT
CCCCCCCCCCCCCCC		27.1821712547
297PhosphorylationNVSFNDTSFTNVPTS
CCCCCCCCCCCCCCC		32.7021712547
303PhosphorylationTSFTNVPTSSPLHQS
CCCCCCCCCCCCCCC		37.2429996109
304PhosphorylationSFTNVPTSSPLHQST
CCCCCCCCCCCCCCC		24.7221712547
305PhosphorylationFTNVPTSSPLHQSTT
CCCCCCCCCCCCCCC		33.6824763107
311PhosphorylationSSPLHQSTTANHPEK
CCCCCCCCCCCCCCC		24.2927738172
319PhosphorylationTANHPEKTPSRAAAS
CCCCCCCCHHHHHHH		25.4921712547
321PhosphorylationNHPEKTPSRAAASLL
CCCCCCHHHHHHHHH		39.5221712547
326PhosphorylationTPSRAAASLLSILDS
CHHHHHHHHHHHHHH		25.7221712547
329PhosphorylationRAAASLLSILDSKEK
HHHHHHHHHHHHCCC		26.8021712547
333PhosphorylationSLLSILDSKEKNTPS
HHHHHHHHCCCCCCC		38.9924763107
338PhosphorylationLDSKEKNTPSITAKA
HHHCCCCCCCCEECC		29.4924763107
340PhosphorylationSKEKNTPSITAKAGS
HCCCCCCCCEECCCC		30.4521712547
347PhosphorylationSITAKAGSPQSAPSK
CCEECCCCCCCCCCC		25.3224763107
350PhosphorylationAKAGSPQSAPSKASY
ECCCCCCCCCCCCCC		45.6024763107
356PhosphorylationQSAPSKASYISPYAR
CCCCCCCCCCCCCCC		27.0829996109
357PhosphorylationSAPSKASYISPYARP
CCCCCCCCCCCCCCC		15.4129996109
359PhosphorylationPSKASYISPYARPGI
CCCCCCCCCCCCCCC		12.0129996109
361PhosphorylationKASYISPYARPGITT
CCCCCCCCCCCCCCC		14.4129996109
367PhosphorylationPYARPGITTSRRRHD
CCCCCCCCCCCCCCC		25.3229996109
369PhosphorylationARPGITTSRRRHDQI
CCCCCCCCCCCCCCC		18.3629996109
422PhosphorylationEKASTHGSFAKQKEG
HHHHHCCCHHCCCCC		17.9021712547
441PhosphorylationLSEKTALSEPENKTP
CCHHHCCCCCCCCCC		48.9525720772
447PhosphorylationLSEPENKTPVFSFKA
CCCCCCCCCCEEEEC		35.9528889911
463PhosphorylationSATTDKPSPPVSSIF
CCCCCCCCCCCHHHE		47.8024763107
645PhosphorylationNVAIDQRSFEQAEKS
EEEECHHHHHHHHHC		27.7424763107
652PhosphorylationSFEQAEKSPISVSES
HHHHHHHCCCCCCCC		20.9721712547
655PhosphorylationQAEKSPISVSESTSL
HHHHCCCCCCCCCCE		23.9921712547
657PhosphorylationEKSPISVSESTSLVE
HHCCCCCCCCCCEEE		21.0224763107
659PhosphorylationSPISVSESTSLVEVE
CCCCCCCCCCEEEEE		18.7821712547
661PhosphorylationISVSESTSLVEVEKP
CCCCCCCCEEEEECC		39.4321712547
692PhosphorylationEKTDKQGSLEEEPFP
EECCCCCCCCCCCCC		30.0728889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NUP60_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NUP60_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NUP60_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SET1_SCHPOset1genetic
18818364
MU154_SCHPOmug154genetic
18818364
SPP1_SCHPOspf1genetic
18818364
RAF1_SCHPOraf1genetic
18818364
ELP2_SCHPOelp2genetic
18818364
ALP14_SCHPOalp14genetic
18818364
MPH1L_SCHPOmph1genetic
22681890
PTF1_SCHPOptf1genetic
22681890
YOI5_SCHPOSPBC1778.05cgenetic
22681890
NU132_SCHPOnup132genetic
22681890
FAM50_SCHPOxap5genetic
22681890
UTP16_SCHPOutp16genetic
22681890
PROB_SCHPOSPAC17H9.13cgenetic
22681890
RNC1_SCHPOrnc1genetic
22681890
ERG28_SCHPOerg28genetic
22681890
CTBL1_SCHPOSPAC1952.06cgenetic
22681890
YJ03_SCHPOrhn1genetic
22681890
YJNG_SCHPOSPCC24B10.16cgenetic
22681890
RAD55_SCHPOrad55genetic
22681890
FEP1_SCHPOfep1genetic
22681890
NEM1_SCHPOnem1genetic
22681890
SPP1_SCHPOspf1genetic
22681890
ULP2_SCHPOulp2genetic
22681890
HRQ1_SCHPOhrq1genetic
22681890
POP2_SCHPOpop2genetic
22681890
YGWH_SCHPOgmh4genetic
22681890
GCN5_SCHPOgcn5genetic
22681890
FTA6_SCHPOfta6genetic
22681890
SWD1_SCHPOswd1genetic
22681890
RHP26_SCHPOrhp26genetic
22681890
YNS7_SCHPOSPBC18H10.07genetic
22681890
PAB2_SCHPOpab2genetic
22681890
MUG80_SCHPOmug80genetic
22681890
DSC4_SCHPOdsc4genetic
22681890
ASH2_SCHPOash2genetic
22681890
YK99_SCHPOSPAC20H4.09genetic
22681890
RAD57_SCHPOrad57genetic
22681890
YGK4_SCHPOSPBC725.04genetic
22681890
YFM8_SCHPOSPAC222.08cgenetic
22681890
YO48_SCHPOSPBC36B7.08cgenetic
22681890
YJM5_SCHPOSPCC1020.05genetic
22681890
ATP11_SCHPOatp11genetic
22681890
RL27A_SCHPOrpl2701genetic
22681890
SET1_SCHPOset1genetic
22681890
YKM2_SCHPOSPAPB24D3.02cgenetic
22681890
ALM1_SCHPOalm1genetic
22681890
IQW1_SCHPOiqw1genetic
22681890
ACH1_SCHPOSPAC1952.09cgenetic
22681890
SHR3_SCHPOpsh3genetic
22681890
YHC3_SCHPOyap18genetic
22681890
FFT3_SCHPOfft3genetic
22681890
YCG6_SCHPOpus3genetic
22681890
YD22_SCHPOSPAC56F8.02genetic
22681890
WDR21_SCHPOwdr21genetic
22681890
MID1_SCHPOmid1genetic
22681890
MU154_SCHPOmug154genetic
22681890
YK42_SCHPOtos4genetic
22681890
MCL1_SCHPOmcl1genetic
22681890
AREH2_SCHPOare2genetic
22681890
YKJ7_SCHPOSPAC513.07genetic
22681890
ASE1_SCHPOase1genetic
22681890
YKK5_SCHPOSPAC2E1P3.05cgenetic
22681890
RGA8_SCHPOrga8genetic
22681890
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NUP60_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157; SER-159; SER-161AND SER-162, AND MASS SPECTROMETRY.

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