| UniProt ID | ASE1_SCHPO | |
|---|---|---|
| UniProt AC | Q9HDY1 | |
| Protein Name | Anaphase spindle elongation protein 1 | |
| Gene Name | ase1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 731 | |
| Subcellular Localization | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Localizes to microtubule overlapping zones during interphase and spindle midzone during anaphase. | |
| Protein Description | Required for anaphase spindle elongation and microtubule bundling in both interphase and mitosis. Has a role in spatial and temporal regulation of septation and cytokinesis and ensures equal partition of segregating sister chromatids. Ensures correct midzone positioning of protein kinase ark1. Acts as a regulatory component at cytokinesis checkpoint where it inhibits nuclear division when actomyosin ring formation is impaired.. | |
| Protein Sequence | MQTVMMDDIQSTDSIAEKDNHSNNESNFTWKAFREQVEKHFSKIERLHQVLGTDGDNSSLFELFTTAMNAQLHEMEQCQKKLEDDCQQRIDSIRFLVSSLKLTDDTSSLKIESPLIQCLNRLSMVEGQYMAQYDQKLSTIKEMYHKLESYCNRLGSPFVLPDFENSFLSDVSDAFTESLRGRINEAEKEIDARLEVINSFEEEILGLWSELGVEPADVPQYEQLLESHTNRPNDVYVTQELIDQLCKQKEVFSAEKEKRSDHLKSIQSEVSNLWNKLQVSPNEQSQFGDSSNINQENISLWETELEKLHQLKKEHLPIFLEDCRQQILQLWDSLFYSEEQRKSFTPMYEDIITEQVLTAHENYIKQLEAEVSANKSFLSLINRYASLIEGKKELEASSNDASRLTQRGRRDPGLLLREEKIRKRLSRELPKVQSLLIPEITAWEERNGRTFLFYDEPLLKICQEATQPKSLYRSASAAANRPKTATTTDSVNRTPSQRGRVAVPSTPSVRSASRAMTSPRTPLPRVKNTQNPSRSISAEPPSATSTANRRHPTANRIDINARLNSASRSRSANMIRQGANGSDSNMSSSPVSGNSNTPFNKFPNSVSRNTHFESKSPHPNYSRTPHETYSKASSKNVPLSPPKQRVVNEHALNIMSEKLQRTNLKEQTPEMDIENSSQNLPFSPMKISPIRASPVKTIPSSPSPTTNIFSAPLNNITNCTPMEDEWGEEGF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 379 | Phosphorylation | SANKSFLSLINRYAS HCCHHHHHHHHHHHH | 25.78 | 25720772 | |
| 472 | Phosphorylation | ATQPKSLYRSASAAA HCCCHHHHHHHHHHH | 15.04 | 21712547 | |
| 474 | Phosphorylation | QPKSLYRSASAAANR CCHHHHHHHHHHHCC | 17.02 | 21712547 | |
| 476 | Phosphorylation | KSLYRSASAAANRPK HHHHHHHHHHHCCCC | 21.49 | 24763107 | |
| 487 | Phosphorylation | NRPKTATTTDSVNRT CCCCCCCCCCCCCCC | 26.58 | 29996109 | |
| 488 | Phosphorylation | RPKTATTTDSVNRTP CCCCCCCCCCCCCCH | 23.17 | 29996109 | |
| 490 | Phosphorylation | KTATTTDSVNRTPSQ CCCCCCCCCCCCHHH | 21.14 | 29996109 | |
| 494 | Phosphorylation | TTDSVNRTPSQRGRV CCCCCCCCHHHCCCE | 23.30 | 29996109 | |
| 496 | Phosphorylation | DSVNRTPSQRGRVAV CCCCCCHHHCCCEEC | 31.71 | 25720772 | |
| 505 | Phosphorylation | RGRVAVPSTPSVRSA CCCEECCCCHHHHHC | 46.48 | 29996109 | |
| 506 | Phosphorylation | GRVAVPSTPSVRSAS CCEECCCCHHHHHCH | 17.32 | 29996109 | |
| 508 | Phosphorylation | VAVPSTPSVRSASRA EECCCCHHHHHCHHH | 30.19 | 29996109 | |
| 517 | Phosphorylation | RSASRAMTSPRTPLP HHCHHHCCCCCCCCC | 34.30 | 29996109 | |
| 518 | Phosphorylation | SASRAMTSPRTPLPR HCHHHCCCCCCCCCC | 10.17 | 29996109 | |
| 521 | Phosphorylation | RAMTSPRTPLPRVKN HHCCCCCCCCCCCCC | 32.34 | 25720772 | |
| 535 | Phosphorylation | NTQNPSRSISAEPPS CCCCCCCCCCCCCCC | 25.82 | 29996109 | |
| 537 | Phosphorylation | QNPSRSISAEPPSAT CCCCCCCCCCCCCCC | 28.03 | 28889911 | |
| 542 | Phosphorylation | SISAEPPSATSTANR CCCCCCCCCCCCCCC | 55.69 | 29996109 | |
| 571 | Phosphorylation | NSASRSRSANMIRQG HHHHHHHHHHHHHCC | 25.82 | 29996109 | |
| 588 | Phosphorylation | GSDSNMSSSPVSGNS CCCCCCCCCCCCCCC | 28.08 | 27738172 | |
| 589 | Phosphorylation | SDSNMSSSPVSGNSN CCCCCCCCCCCCCCC | 23.24 | 29996109 | |
| 592 | Phosphorylation | NMSSSPVSGNSNTPF CCCCCCCCCCCCCCC | 35.32 | 27738172 | |
| 595 | Phosphorylation | SSPVSGNSNTPFNKF CCCCCCCCCCCCHHC | 45.68 | 27738172 | |
| 616 | Phosphorylation | NTHFESKSPHPNYSR CCCCCCCCCCCCCCC | 37.41 | 24763107 | |
| 622 | Phosphorylation | KSPHPNYSRTPHETY CCCCCCCCCCCCCCC | 36.00 | 21712547 | |
| 624 | Phosphorylation | PHPNYSRTPHETYSK CCCCCCCCCCCCCCC | 24.05 | 21712547 | |
| 630 | Phosphorylation | RTPHETYSKASSKNV CCCCCCCCCCCCCCC | 29.21 | 21712547 | |
| 640 | Phosphorylation | SSKNVPLSPPKQRVV CCCCCCCCCCCHHHC | 32.84 | 28889911 | |
| 668 | Phosphorylation | RTNLKEQTPEMDIEN HCCCCCCCCCCCCCC | 23.47 | 24763107 | |
| 676 | Phosphorylation | PEMDIENSSQNLPFS CCCCCCCCCCCCCCC | 22.10 | 21712547 | |
| 677 | Phosphorylation | EMDIENSSQNLPFSP CCCCCCCCCCCCCCC | 34.37 | 21712547 | |
| 683 | Phosphorylation | SSQNLPFSPMKISPI CCCCCCCCCCEECCC | 23.34 | 24763107 | |
| 688 | Phosphorylation | PFSPMKISPIRASPV CCCCCEECCCCCCCC | 14.57 | 24763107 | |
| 693 | Phosphorylation | KISPIRASPVKTIPS EECCCCCCCCCCCCC | 22.00 | 24763107 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ASE1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ASE1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ASE1_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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