KLP2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLP2_SCHPO
• UniProt AC: Q9US03
• Protein Name: Kinesin-like protein 2
• Gene Name: klp2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 817
• Subcellular Localization: Cytoplasm, cytoskeleton. Nucleus. During interphase. When in the nucleus, it associates with chromatin.
• Protein Description: Microtubule-dependent motor that is involved in microtubule organization in the mitotic spindle. Required for the polarization of interphase microtubules where it orients the microtubule plus ends toward the cell ends and the minus ends toward the cell center. Mediates minus end-directed sliding of cytoplasmic microtubules relative to each other, thereby promoting mitotic spindle disassembly..
• Protein Sequence: MEEEGHKSLTSHLPQSSSSLSQSREIAKEFTSNIPPPTIKTNSSSSNILKPRLSLQNEVNQLKPAKFPSKMLPPGSLASVKSSSLAKKARPFTASSNPRMPKSAHPISSRSVSASSHFGRPASAVSSSLNSSDDVRSMSDESMESYNDEKSVNASALRTTEDRLRSMEMAYAQLSAKVIPSPSKRPANYKFYEQRIAMLEESLEVERSRTSELQEQFSVALREKAEAEANKIVSQKGMESLEIMLNSMKSENHQRMAMLEENHARVMETAELQHQAELQDFASNIEQKANSLIMEYKNELQSAEEHFSHKIKELTSENELKISRLQEEKDSLLKKVQEGASLAMQRVQNKHDLEKKRLQSAIQPLQEENNSLKQQIEQLQRELASETVVKENLKSSLDQQSANVQKLESTNRALESTIKTLEEDVYTMKNKIIELEGILKSANVERDGLVEKLIAEETLRRKLHNTIQELKGNIRVFCRVRPPLGDGESAQIAFPDQNSEASTIEIVAQAPGSSLTGNGIKQYAFNFDRVFSPETTNEDVFNELSQLIQSAMDGYNVCIFAYGQTGSGKTHTMSSNTGMIPSSVRMIYNRSTSLKERGWEYRMEGQFLEIYNETIIDLLASGNEEEKGKKKLEIYHDTKAGRTTITNITSEPLDTPEQVTWLLDQASKNRSVAATNANEHSSRSHSVFMLHLNGSNSTTGETCRSTLNLIDLAGSERLSSSQSVGERLKETQAINKSLSCLGDVIHALGSGKEGTYIPYRNSKLTNLLQYSLGGNSKTLMFVNISPLKQHVPETLCSLRFATKVNNTQIGTARKVTK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	NILKPRLSLQNEVNQ CCCCCCHHHHHHHHH	29.23	24763107
111	Phosphorylation	AHPISSRSVSASSHF CCCCCCCCCCCCCCC	23.52	29996109
113	Phosphorylation	PISSRSVSASSHFGR CCCCCCCCCCCCCCC	24.55	25720772
115	Phosphorylation	SSRSVSASSHFGRPA CCCCCCCCCCCCCCH	19.48	29996109
137	Phosphorylation	NSSDDVRSMSDESME CCCHHHHHCCHHHHH	23.61	25720772
139	Phosphorylation	SDDVRSMSDESMESY CHHHHHCCHHHHHHH	39.20	25720772
142	Phosphorylation	VRSMSDESMESYNDE HHHCCHHHHHHHCCC	32.61	25720772
181	Phosphorylation	LSAKVIPSPSKRPAN HHCCCCCCCCCCCCC	30.59	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLP2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLP2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLP2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KLP9_SCHPO	klp9	genetic	22264609
DYHC_SCHPO	dhc1	genetic	23087209
YBH4_SCHPO	SPBC3B8.04c	genetic	22681890
GPD1_SCHPO	gpd1	genetic	22681890
ARF6_SCHPO	arf6	genetic	22681890
TOM70_SCHPO	tom70	genetic	22681890
DYHC_SCHPO	dhc1	genetic	25869666
DIL1_SCHPO	dli1	genetic	25869666

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.