VAC7_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VAC7_SCHPO
• UniProt AC: O94262
• Protein Name: Vacuolar segregation protein 7
• Gene Name: vac7
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 251
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein . Vacuole membrane; Single-pass type II membrane protein.
• Protein Description: Component of the PI(3,5)P2 regulatory complex that regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Directly involved in vacuolar membrane scission. Required for normal vacuole acidification, inheritance and morphology (By similarity)..
• Protein Sequence: MSEPKPMQMSVETETVLNVSQVQIPSSCDRKASLETLKTKKNAQKKKKISLPNVMTSKAAMFAARVASAVDQDPNDEESENFVYENLIPTNDDELHSPSASIHSFQTYNLPLEMLPTINHVPYYGSAGTNALNGGPLSNSRKLIPKRSAKFSSMVGSSDTRCNSPTTARGLATSPLQINPTTSKSPLLNKKLSSTSQEPFRTSRRSGQESGDVTTKMLRNLLHKRLWISFFFACFVVLSLVYFHYAVQPLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	N-linked_Glycosylation	VETETVLNVSQVQIP EEEEEEECHHHCCCC		-
33	Phosphorylation	SSCDRKASLETLKTK CCCCCCHHHHHHHHH		25720772
36	Phosphorylation	DRKASLETLKTKKNA CCCHHHHHHHHHHHH		25720772
152	Phosphorylation	PKRSAKFSSMVGSSD CCCHHHHHHHCCCCC		21712547
160	Phosphorylation	SMVGSSDTRCNSPTT HHCCCCCCCCCCCCC		25720772
164	Phosphorylation	SSDTRCNSPTTARGL CCCCCCCCCCCCCCC		21712547
174	Phosphorylation	TARGLATSPLQINPT CCCCCCCCCCCCCCC		29996109
193	Phosphorylation	PLLNKKLSSTSQEPF CCCCCCCCCCCCCCH		29996109
194	Phosphorylation	LLNKKLSSTSQEPFR CCCCCCCCCCCCCHH		21712547
195	Phosphorylation	LNKKLSSTSQEPFRT CCCCCCCCCCCCHHH		29996109
196	Phosphorylation	NKKLSSTSQEPFRTS CCCCCCCCCCCHHHC		25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VAC7_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VAC7_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VAC7_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of VAC7_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.