| UniProt ID | NSK1_SCHPO | |
|---|---|---|
| UniProt AC | Q7LL22 | |
| Protein Name | Kinetochore protein nsk1 | |
| Gene Name | nsk1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 462 | |
| Subcellular Localization | Nucleus, nucleolus . Cytoplasm, cytoskeleton, spindle . Chromosome, centromere, kinetochore . Undergoes cell cycle-dependent localization changes, nucleolar during interphase, distributed in the nucleoplasm during metaphase, and increased at kinetoch | |
| Protein Description | Ensures chromosome alignment and accurate chromosome segregation during mitosis. Promotes proper kinetochore-microtubule (k-MT) interactions during anaphase B. The phosphorylation status of nsk1 affects the proper k-MT coupling, ensuring that it interacts stably only at the correct time during mitosis.. | |
| Protein Sequence | MAYKLSLSAVEPLLIFPAAPFSTKKEKSTFQNNLISSDVFSSALKPLSPLKSLVADFSTHSNPSKDNQLISPPKINHREFLNEEKESDTQTRYLKQLINICNSPSKNHETSLSPSKSTIDNNERKLDNEIDNYKHDVKYSPYKGQGKTSNPSQGTTKCPGIFEEDNFFSVSPKRRKNLFEKYGKTDLGKPARVPSPKKSLSSTIKSPPSRVKLPTSILSKSPPLKVPNKNRSSTFSPLRTPTSSSKTFVIVDHSTPSPPSIRTKLEAFAPNSTFATQKRLRRLATLESSPALRSTLKSLQSKSSPVKLLKLKEEKAKIKNQLFKSEEEKDPVGKQKLPLESSLSPLDHSSAEKEMQKAPAKNKRRRTGSLETGLYPKESPTPSKKRSKRVLWSLKHIVSPGNREKHSLNSTPESIMKKDTKWPQNLAKNNINSEPNTPTKSNIDTGKAHSARAHKTRKNIQS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 36 | Phosphorylation | TFQNNLISSDVFSSA CHHHCCCCHHHHHHH | 21712547 | ||
| 41 | Phosphorylation | LISSDVFSSALKPLS CCCHHHHHHHCCCCC | 24763107 | ||
| 42 | Phosphorylation | ISSDVFSSALKPLSP CCHHHHHHHCCCCCC | 21712547 | ||
| 48 | Phosphorylation | SSALKPLSPLKSLVA HHHCCCCCCHHHHHH | 24763107 | ||
| 103 | Phosphorylation | QLINICNSPSKNHET HHHHHHCCCCCCCCC | 29996109 | ||
| 111 | Phosphorylation | PSKNHETSLSPSKST CCCCCCCCCCCCCHH | 21712547 | ||
| 113 | Phosphorylation | KNHETSLSPSKSTID CCCCCCCCCCCHHCC | 24763107 | ||
| 219 | Phosphorylation | KLPTSILSKSPPLKV CCCHHHHCCCCCCCC | 21712547 | ||
| 221 | Phosphorylation | PTSILSKSPPLKVPN CHHHHCCCCCCCCCC | 21712547 | ||
| 232 | Phosphorylation | KVPNKNRSSTFSPLR CCCCCCCCCCCCCCC | 21712547 | ||
| 233 | Phosphorylation | VPNKNRSSTFSPLRT CCCCCCCCCCCCCCC | 21712547 | ||
| 234 | Phosphorylation | PNKNRSSTFSPLRTP CCCCCCCCCCCCCCC | 24763107 | ||
| 236 | Phosphorylation | KNRSSTFSPLRTPTS CCCCCCCCCCCCCCC | 21712547 | ||
| 240 | Phosphorylation | STFSPLRTPTSSSKT CCCCCCCCCCCCCCE | 21712547 | ||
| 242 | Phosphorylation | FSPLRTPTSSSKTFV CCCCCCCCCCCCEEE | 21712547 | ||
| 243 | Phosphorylation | SPLRTPTSSSKTFVI CCCCCCCCCCCEEEE | 21712547 | ||
| 244 | Phosphorylation | PLRTPTSSSKTFVIV CCCCCCCCCCEEEEE | 24763107 | ||
| 254 | Phosphorylation | TFVIVDHSTPSPPSI EEEEECCCCCCCCCH | 25720772 | ||
| 255 | Phosphorylation | FVIVDHSTPSPPSIR EEEECCCCCCCCCHH | 24763107 | ||
| 257 | Phosphorylation | IVDHSTPSPPSIRTK EECCCCCCCCCHHHH | 24763107 | ||
| 260 | Phosphorylation | HSTPSPPSIRTKLEA CCCCCCCCHHHHHHH | 24763107 | ||
| 263 | Phosphorylation | PSPPSIRTKLEAFAP CCCCCHHHHHHHHCC | 21712547 | ||
| 285 | Phosphorylation | KRLRRLATLESSPAL HHHHHHHHHHCCHHH | 29996109 | ||
| 288 | Phosphorylation | RRLATLESSPALRST HHHHHHHCCHHHHHH | 29996109 | ||
| 289 | Phosphorylation | RLATLESSPALRSTL HHHHHHCCHHHHHHH | 29996109 | ||
| 341 | Phosphorylation | KQKLPLESSLSPLDH CCCCCCCCCCCCCCC | 21712547 | ||
| 342 | Phosphorylation | QKLPLESSLSPLDHS CCCCCCCCCCCCCCH | 24763107 | ||
| 344 | Phosphorylation | LPLESSLSPLDHSSA CCCCCCCCCCCCHHH | 24763107 | ||
| 350 | Phosphorylation | LSPLDHSSAEKEMQK CCCCCCHHHHHHHHH | 21712547 | ||
| 367 | Phosphorylation | AKNKRRRTGSLETGL CCCCCCCCCCCCCCC | 29996109 | ||
| 369 | Phosphorylation | NKRRRTGSLETGLYP CCCCCCCCCCCCCCC | 29996109 | ||
| 399 | Phosphorylation | WSLKHIVSPGNREKH HHHEECCCCCCHHHC | 24763107 | ||
| 407 | Phosphorylation | PGNREKHSLNSTPES CCCHHHCCCCCCHHH | 21712547 | ||
| 410 | Phosphorylation | REKHSLNSTPESIMK HHHCCCCCCHHHHHH | 24763107 | ||
| 411 | Phosphorylation | EKHSLNSTPESIMKK HHCCCCCCHHHHHHC | 21712547 | ||
| 414 | Phosphorylation | SLNSTPESIMKKDTK CCCCCHHHHHHCCCC | 24763107 | ||
| 433 | Phosphorylation | LAKNNINSEPNTPTK HHHCCCCCCCCCCCC | 24763107 | ||
| 437 | Phosphorylation | NINSEPNTPTKSNID CCCCCCCCCCCCCCC | 24763107 | ||
| 439 | Phosphorylation | NSEPNTPTKSNIDTG CCCCCCCCCCCCCCC | 29996109 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 71 | S | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 103 | S | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 113 | S | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 140 | S | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 171 | S | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 195 | S | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 206 | S | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 221 | S | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 236 | S | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 240 | T | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 255 | T | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 257 | S | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 289 | S | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 344 | S | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 379 | S | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 399 | S | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 411 | T | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| 437 | T | Phosphorylation | Kinase | CDK1 | P04551 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NSK1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NSK1_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MPH1L_SCHPO | mph1 | genetic | 22065639 | |
| SPC7_SCHPO | spc7 | genetic | 22065639 | |
| MIS6_SCHPO | mis6 | genetic | 22065639 | |
| CDK1_SCHPO | cdc2 | physical | 22065639 | |
| ARK1_SCHPO | ark1 | genetic | 22065639 | |
| PP11_SCHPO | dis2 | genetic | 22065639 | |
| DYLT_SCHPO | dlc1 | physical | 22065639 | |
| FLP1_SCHPO | clp1 | physical | 22065639 | |
| MAD2_SCHPO | mad2 | genetic | 21965289 | |
| MAD3_SCHPO | mad3 | genetic | 21965289 | |
| NSE6_SCHPO | nse6 | genetic | 22681890 | |
| SWR1_SCHPO | swr1 | genetic | 22681890 | |
| YEG5_SCHPO | mga2 | genetic | 22681890 | |
| LUB1_SCHPO | lub1 | genetic | 22681890 | |
| SEY1_SCHPO | SPAC222.14c | genetic | 22681890 | |
| HRQ1_SCHPO | hrq1 | genetic | 22681890 | |
| MSA1_SCHPO | msa1 | genetic | 22681890 | |
| NOT3_SCHPO | not3 | genetic | 22681890 | |
| YO48_SCHPO | SPBC36B7.08c | genetic | 22681890 | |
| MAD2_SCHPO | mad2 | genetic | 22681890 | |
| YORS_SCHPO | stc1 | genetic | 22681890 | |
| FFT3_SCHPO | fft3 | genetic | 22681890 | |
| ASE1_SCHPO | ase1 | genetic | 22681890 | |
| ATG11_SCHPO | atg11 | physical | 26771498 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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