| UniProt ID | NOT3_SCHPO | |
|---|---|---|
| UniProt AC | O13870 | |
| Protein Name | General negative regulator of transcription subunit 3 | |
| Gene Name | not3 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 640 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity).. | |
| Protein Sequence | MSARKLQVEIEKTFKKVTDGIAIFDEVYEKLSASNSVSQKEKLEGDLKTQIKKLQRLRDQIKTWASSNDIKDKKALLENRRLIEAKMEEFKAVEREMKIKAFSKEGLSIASKLDPKEKEKQDTIQWISNAVEELERQAELIEAEAESLKATFKRGKKDLSKLSHLSELESRIERHKWHQDKLELIMRRLENSQISPEAVNDIQEDIMYYVECSQSEDFAEDENLYDELNLDEASASYDAERSGRSSSSSHSPSPSASSSSSSENLLQDKAEAEEKVSADASVQDIAEKESLDADKELATNDQEDDEEENQAETQKDGAISNNENMQSEVQTTNPSASTSAVTNITKPTLIQNPSTPLSVSNSKVASPETPNATHTAPKVEMRYASAAAAAAAALAKESPSHHYIMQQVRPETPNSPRLNSTVIQSKWDSLGHTASPKMQTQPVRSVSQSSATTETNVKPTKEENADVPVSSPDYLKDLVNALNTSKEQHKGAIDKEKLTEALNISCVYVPDATDAAKPQYYIPKDPYPVPHYYPQQPLPLFDSSEMTELVDPDTLFYMFYYRPGTYQQYIAGQELKKQSWRFHKKYTTWFQRHEEPKMITDEFESGSYRYFDFEGDWVQRKKADFRFTYQYLEDDDDWTR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 247 | Phosphorylation | ERSGRSSSSSHSPSP HHHCCCCCCCCCCCC | 36.79 | 19547744 | |
| 248 | Phosphorylation | RSGRSSSSSHSPSPS HHCCCCCCCCCCCCC | 33.74 | 28889911 | |
| 249 | Phosphorylation | SGRSSSSSHSPSPSA HCCCCCCCCCCCCCC | 29.90 | 28889911 | |
| 251 | Phosphorylation | RSSSSSHSPSPSASS CCCCCCCCCCCCCCC | 29.08 | 28889911 | |
| 253 | Phosphorylation | SSSSHSPSPSASSSS CCCCCCCCCCCCCCC | 34.21 | 28889911 | |
| 255 | Phosphorylation | SSHSPSPSASSSSSS CCCCCCCCCCCCCCH | 45.16 | 27738172 | |
| 258 | Phosphorylation | SPSPSASSSSSSENL CCCCCCCCCCCHHHH | 33.68 | 27738172 | |
| 260 | Phosphorylation | SPSASSSSSSENLLQ CCCCCCCCCHHHHHH | 39.57 | 29996109 | |
| 261 | Phosphorylation | PSASSSSSSENLLQD CCCCCCCCHHHHHHH | 43.55 | 29996109 | |
| 262 | Phosphorylation | SASSSSSSENLLQDK CCCCCCCHHHHHHHH | 32.24 | 29996109 | |
| 277 | Phosphorylation | AEAEEKVSADASVQD HHHHHHHCCCCHHHH | 31.34 | 21712547 | |
| 281 | Phosphorylation | EKVSADASVQDIAEK HHHCCCCHHHHHHHH | 22.36 | 19547744 | |
| 290 | Phosphorylation | QDIAEKESLDADKEL HHHHHHHCCCHHHHH | 42.49 | 24763107 | |
| 339 | Phosphorylation | TNPSASTSAVTNITK CCCCCCCCCCCCCCC | 20.46 | 27738172 | |
| 354 | Phosphorylation | PTLIQNPSTPLSVSN CCCCCCCCCCCEECC | 50.65 | 27738172 | |
| 355 | Phosphorylation | TLIQNPSTPLSVSNS CCCCCCCCCCEECCC | 29.52 | 21712547 | |
| 358 | Phosphorylation | QNPSTPLSVSNSKVA CCCCCCCEECCCCCC | 25.38 | 24763107 | |
| 360 | Phosphorylation | PSTPLSVSNSKVASP CCCCCEECCCCCCCC | 31.82 | 21712547 | |
| 362 | Phosphorylation | TPLSVSNSKVASPET CCCEECCCCCCCCCC | 22.47 | 24763107 | |
| 366 | Phosphorylation | VSNSKVASPETPNAT ECCCCCCCCCCCCCC | 26.68 | 28889911 | |
| 369 | Phosphorylation | SKVASPETPNATHTA CCCCCCCCCCCCCCC | 25.81 | 28889911 | |
| 373 | Phosphorylation | SPETPNATHTAPKVE CCCCCCCCCCCCCHH | 26.80 | 21712547 | |
| 375 | Phosphorylation | ETPNATHTAPKVEMR CCCCCCCCCCCHHHH | 40.06 | 21712547 | |
| 385 | Phosphorylation | KVEMRYASAAAAAAA CHHHHHHHHHHHHHH | 14.98 | - | |
| 398 | Phosphorylation | AAALAKESPSHHYIM HHHHHHHCCCCCCCC | 30.88 | 21712547 | |
| 400 | Phosphorylation | ALAKESPSHHYIMQQ HHHHHCCCCCCCCCC | 31.98 | 29996109 | |
| 403 | Phosphorylation | KESPSHHYIMQQVRP HHCCCCCCCCCCCCC | 7.83 | 29996109 | |
| 412 | Phosphorylation | MQQVRPETPNSPRLN CCCCCCCCCCCCCCC | 30.38 | 19547744 | |
| 415 | Phosphorylation | VRPETPNSPRLNSTV CCCCCCCCCCCCCHH | 16.76 | 19547744 | |
| 429 | Phosphorylation | VIQSKWDSLGHTASP HHHHHHHHCCCCCCC | 34.83 | 21712547 | |
| 433 | Phosphorylation | KWDSLGHTASPKMQT HHHHCCCCCCCCCCC | 27.34 | 28889911 | |
| 435 | Phosphorylation | DSLGHTASPKMQTQP HHCCCCCCCCCCCCC | 26.64 | 28889911 | |
| 445 | Phosphorylation | MQTQPVRSVSQSSAT CCCCCCEECCCCCCC | 26.76 | 24763107 | |
| 447 | Phosphorylation | TQPVRSVSQSSATTE CCCCEECCCCCCCCC | 26.12 | 25720772 | |
| 449 | Phosphorylation | PVRSVSQSSATTETN CCEECCCCCCCCCCC | 17.90 | 28889911 | |
| 450 | Phosphorylation | VRSVSQSSATTETNV CEECCCCCCCCCCCC | 23.23 | 19547744 | |
| 452 | Phosphorylation | SVSQSSATTETNVKP ECCCCCCCCCCCCCC | 27.41 | 21712547 | |
| 453 | Phosphorylation | VSQSSATTETNVKPT CCCCCCCCCCCCCCC | 40.29 | 19547744 | |
| 455 | Phosphorylation | QSSATTETNVKPTKE CCCCCCCCCCCCCCH | 43.13 | 29996109 | |
| 460 | Phosphorylation | TETNVKPTKEENADV CCCCCCCCCHHCCCC | 45.42 | 21712547 | |
| 470 | Phosphorylation | ENADVPVSSPDYLKD HCCCCCCCCHHHHHH | 30.04 | 29996109 | |
| 471 | Phosphorylation | NADVPVSSPDYLKDL CCCCCCCCHHHHHHH | 23.25 | 28889911 | |
| 474 | Phosphorylation | VPVSSPDYLKDLVNA CCCCCHHHHHHHHHH | 21.02 | 28889911 | |
| 607 | Phosphorylation | TDEFESGSYRYFDFE CCCCCCCCEEEEECC | 18.73 | 25720772 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NOT3_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NOT3_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NOT3_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248; SER-249; SER-251;SER-253; SER-366; THR-369; THR-433; SER-435; SER-449; SER-471 ANDTYR-474, AND MASS SPECTROMETRY. | |
